Results 51 to 60 of about 2,762 (187)

A novel feature selection algorithm for identifying hub genes in lung cancer

Scientific Reports, 2023
Lung cancer, a life-threatening disease primarily affecting lung tissue, remains a significant contributor to mortality in both developed and developing nations.
Tehnan I. A. Mohamed, Absalom E. Ezugwu, Jean Vincent Fonou-Dombeu, Mohanad Mohammed, Japie Greeff, Murtada K. Elbashir   +5 more
doaj   +1 more source

Whole-genome association analysis of pork meat pH revealed three significant regions and several potential genes in Finnish Yorkshire pigs [PDF]

, 2017
Background: One of the most commonly used quality measurements of pork is pH measured 24 h after slaughter. The most probable mode of inheritance for this trait is oligogenic with several known major genes, such as PRKAG3.
Hietakangas, Ville, Serenius, Timo, Sevon-Aimonen, Marja-Liisa, Uimari, Pekka, Verardo, Lucas L.   +4 more
core   +1 more source

Ulk4 regulates GABAergic signaling and anxiety-related behavior [PDF]

, 2018
Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene encoding a putative Serine ...
A Cooper, A Hogart, A Lippa, A MacKenzie-Graham, A Marowsky, A Paydar, A Viggiano, AA Walf, AM Addington, B Burns, B Lang, B Lang, CB Nemeroff, CR Marshall, D Azzinnari, D Bosch, D Pinto, D Rujescu, DA Lewis, DM Kerr, DM Kerr, G Fenalti, G Kirov, GJ Qu, HU Wittchen, JJ Nadler, JJ Soghomonian, JN Crawley, JT Glessner, K Njunge, KD Micheva, KV Barnes, KV Sandhu, L Dominguez, LW Jin, M Liu, M Liu, M Seney, MJ Millan, MR Zarrindast, O Stork, P Muglia, PG Unschuld, RB Lydiard, RMJ Deacon, S Chung, S Heckers, S Muhie, SA Heldt, SF Kash, T Hashimoto, T Toyota, WC Skarnes, WF Schwindinger, WH Chou, Y Gonchar   +55 more
core   +3 more sources

Candidate human genetic polymorphisms and severe malaria in a Tanzanian population.

PLoS ONE, 2012
Human genetic background strongly influences susceptibility to malaria infection and progression to severe disease and death. Classical genetic studies identified haemoglobinopathies and erythrocyte-associated polymorphisms, as protective against severe ...
Alphaxard Manjurano, Taane G Clark, Behzad Nadjm, George Mtove, Hannah Wangai, Nuno Sepulveda, Susana G Campino, Caroline Maxwell, Raimos Olomi, Kirk R Rockett, Anna Jeffreys, MalariaGen Consortium, Eleanor M Riley, Hugh Reyburn, Christopher Drakeley   +14 more
doaj   +1 more source

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation [PDF]

, 2016
Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing differentiated and dedifferentiated proliferating states in vivo .
Andersson, TB, Bell, CC, Ellis, E, Goldring, CE, Hendriks, DFG, Ingelman-Sundberg, M, Johansson, I, Lauschke, VM, Mkrtchian, S, Moro, SML, Nordling, A, Park, BK, Rezayee, F, Sison-Young, R, Vorrink, SU   +14 more
core   +1 more source

Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages [PDF]

, 2014
Cognitive decline is associated with gene expression changes in the brain, but the transcriptional mechanisms underlying memory impairments in cognitive disorders, such as Alzheimer's disease (AD), are largely unknown.
Chen, Meng, España Agustí, Judit, Ferrer, Isidro, Martín, Elsa, Parra Damas, Arnaldo J., Rodríguez Álvarez, José, Saura Antolín, Carlos A., Valero, Jorge   +7 more
core   +5 more sources

Comparison of the central human and mouse platelet signaling cascade by systems biological analysis

BMC Genomics, 2020
Background Understanding the molecular mechanisms of platelet activation and aggregation is of high interest for basic and clinical hemostasis and thrombosis research.
Johannes Balkenhol, Kristin V. Kaltdorf, Elmina Mammadova-Bach, Attila Braun, Bernhard Nieswandt, Marcus Dittrich, Thomas Dandekar   +6 more
doaj   +1 more source

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition [PDF]

, 2014
BRAFV600E-mutant malignant melanomas depend on RAF/MEK/ERK (MAPK) signaling for tumor cell growth1. RAF and MEK inhibitors show remarkable clinical efficacy in BRAFV600E melanoma2, 3; however, resistance to these agents remains a formidable challenge2, 4.
Donahue, Melanie K., Flaherty, Keith T., Frederick, Dennie T., Garraway, Levi A., Johannessen, Cory M., Johnson, Laura A., Narayan, Rajiv, Piccioni, Federica, Root, David E., Townes, Aisha, Wargo, Jennifer A.   +10 more
core   +1 more source

Phosphoproteomic profiling of the hippocampus of offspring rats exposed to prenatal stress

Brain and Behavior, 2021
Introduction Prenatal stress (PS) can cause depression in offspring. However, the underlying biological mechanism of these influences is still unclear.
Qinghong Li, Dongge Cai, Huimei Huang, Huiping Zhang, Ruimiao Bai, Xiaolin Zhao, Hongli Sun, Pei Qin   +7 more
doaj   +1 more source

Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes [PDF]

, 2015
BACKGROUND - : Cardiovascular disease (CVD) reflects a highly coordinated complex of traits. Although genome-wide association studies have reported numerous single nucleotide polymorphisms (SNPs) to be associated with CVD, the role of most of these ...
Chen, B.H., Courchesne P., Cupples L.A., Fox, C.S., Freedman J.E., Huan, T., Joehanes, R., Keles, S., Levy, D., Liu, C., Meigs J.B., Munson P.J., O'Donnell, C.J., Otlu, B., Tastan O., Yao, C., Zhang X.   +16 more
core   +1 more source