Membrane protein biogenesis at the ER: the highways and byways
The FEBS Journal, Volume 289, Issue 22, Page 6835-6862, November 2022., 2022 In eukaryotes, one third of cellular proteins are co‐translationally inserted into or translocated across the membrane of the endoplasmic reticulum during their biogenesis. Here, we distil recent advances in our understanding of this process; highlighting the Sec61 translocon as a dynamic hub that co‐ordinates the roles of key partners to provide a ...
Sarah O'Keefe +2 more
wiley +1 more source
Rapid evolution fuels transcriptional plasticity to ocean acidification
Global Change Biology, Volume 28, Issue 9, Page 3007-3022, May 2022., 2022 Elevated pCO2 induced common molecular responses related to circadian rhythm and immune system but different magnitudes of response across six species. Acanthochromis polyacanthus exhibited many more differentially expressed genes with a more rapid evolutionary rate fuelling the increased transcriptional plasticity Abstract Ocean acidification (OA) is ...
Jingliang Kang +6 more
wiley +1 more source
Whole-genome association analysis of pork meat pH revealed three significant regions and several potential genes in Finnish Yorkshire pigs [PDF]
, 2017 Background: One of the most commonly used quality measurements of pork is pH measured 24 h after slaughter. The most probable mode of inheritance for this trait is oligogenic with several known major genes, such as PRKAG3.
Hietakangas, Ville +4 more
core +1 more source
The battle of the sexes starts in the oviduct: modulation of oviductal transcriptome by X and Y-bearing spermatozoa [PDF]
, 2014 BACKGROUND:Sex allocation of offspring in mammals is usually considered as a matter of chance, being dependent on whether an X- or a Y-chromosome-bearing spermatozoon reaches the oocyte first. Here we investigated the alternative possibility, namely that
Alminana, C. +12 more
core +3 more sources
Comparison of the central human and mouse platelet signaling cascade by systems biological analysis
BMC Genomics, 2020 Background Understanding the molecular mechanisms of platelet activation and aggregation is of high interest for basic and clinical hemostasis and thrombosis research.
Johannes Balkenhol +6 more
doaj +1 more source
Phosphoproteomic profiling of the hippocampus of offspring rats exposed to prenatal stress
Brain and Behavior, 2021 Introduction Prenatal stress (PS) can cause depression in offspring. However, the underlying biological mechanism of these influences is still unclear.
Qinghong Li +7 more
doaj +1 more source
Candidate human genetic polymorphisms and severe malaria in a Tanzanian population.
PLoS ONE, 2012 Human genetic background strongly influences susceptibility to malaria infection and progression to severe disease and death. Classical genetic studies identified haemoglobinopathies and erythrocyte-associated polymorphisms, as protective against severe ...
Alphaxard Manjurano +14 more
doaj +1 more source
Steroidogenesis-related gene expression in the rat ovary exposed to melatonin supplementation [PDF]
, 2015 OBJECTIVE: To analyze steroidogenesis-related gene expression in the rat ovary exposed to melatonin supplementation. METHODS: Thirty-two virgin adult female rats were randomized to two groups as follows: the control group GI received vehicle and the ...
Baracat, Edmund Chada +8 more
core +4 more sources
Nutrition & Metabolism, 2022 Background Single-nucleotide polymorphisms (SNPs) in various genetic loci are associated with childhood obesity; however, their influence on adolescent growth patterns has rarely been explored.
Yi-Fan Wu +2 more
doaj +1 more source
Modulation of the neurotransmitter systems through the anti-inflammatory and antidepressant-like effects of squalene from Aurantiochytrium sp. [PDF]
, 2019 Although algae have been the focal point of biofuel research, studies on their biological activities have been limited. In recent years, however, the importance of algae as sources of functional ingredients has been recognized due to their health ...
Farhana Ferdousi +9 more
core +2 more sources