Results 51 to 60 of about 2,548 (156)

Coxiella burnetii and Leishmania Mexicana Residing Within Similar Parasitophorous Vacuoles Elicit Disparate Host Responses [PDF]

, 2015
Coxiella burnetii is a bacterium that thrives in an acidic parasitophorous vacuole (PV) derived from lysosomes. Leishmania mexicana, a eukaryote, has also independently evolved to live in a morphologically similar PV.
Cambronne, Eric D., Kacharia, Fenil, Landfear, Scott M., Malchiodi, Emilio Luis, Millar, Jess A., Raghavan, Rahul, Soong, Lynn, Valdés, Raquel   +7 more
core   +1 more source

Paraoxonase‐2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non‐alcoholic steatohepatitis

British Journal of Pharmacology, Volume 181, Issue 19, Page 3717-3742, October 2024.
Abstract Background and Purpose Only limited therapeutic agents have been developed for non‐alcoholic steatohepatitis (NASH). Glabridin, a promising anti‐obesity candidate, has only limited druggability due to its low in vivo chemical stability and bioavailability.
Gu‐Choul Shin, Hyeong Min Lee, Nayeon Kim, Jihyeon Hur, Sang‐Ku Yoo, Yun Sun Park, Hyung Soon Park, Dongryeol Ryu, Min‐Ho Park, Jung Hee Park, Sang‐Uk Seo, Leo Sungwong Choi, Martin Rønn Madsen, Michael Feigh, Kwang Pyo Kim, Kyun‐Hwan Kim   +15 more
wiley   +1 more source

Integration of multiomics data identifies candidate genes influencing pH levels in Beijing Black pigs

Animal Research and One Health, Volume 2, Issue 3, Page 260-272, August 2024.
To explore the genetic mechanism of pH values, we measured the pH values at 2 h (pH2h) and 24 h (pH24h) postmortem in the longissimus dorsi muscle of Beijing Black pigs. A total of 614 Beijing Black pigs were genotyped by the Illumina Porcine 50K SNP Chip. We conducted a genome‐wide association study and RNA sequencing (RNA‐seq) analysis.
Jingjing Tian, Naiqi Niu, Xiaoqing Wang, Liangyu Shi, Liyu Yang, Mianyan Li, Lijun Shi, Xin Liu, Hongmei Gao, Xinhua Hou, Ligang Wang, Lixian Wang, Longchao Zhang, Fuping Zhao   +13 more
wiley   +1 more source

Genomic Counter-Stress Changes Induced by the Relaxation Response [PDF]

, 2013
Background: Mind-body practices that elicit the relaxation response (RR) have been used worldwide for millennia to prevent and treat disease. The RR is characterized by decreased oxygen consumption, increased exhaled nitric oxide, and reduced ...
Benson, Herbert, Bhasin, Manoj, Dusek, Jeffery A., Joseph, Marie G., Libermann, Towia Aron, Otu, Hasan H, Wohlhueter, Ann L., Zerbini, Luiz F.   +7 more
core   +1 more source

Physiological responses to a changing winter climate in an early spring‐breeding amphibian

Ecology and Evolution, Volume 14, Issue 7, July 2024.
Climate change is swiftly altering environmental winter conditions, leading to significant ecological impacts such as phenological shifts in many species. Our study points for the first time to the complex physiological challenges that amphibians face as a result of changing thermal conditions due to winter climate change.
Robin Schmidt, Cecile Zummach, Noa Sinai, Joana Sabino‐Pinto, Sven Künzel, Kathrin H. Dausmann, Katharina Ruthsatz   +6 more
wiley   +1 more source

Genome-wide dissection of microRNA functions and cotargeting networks using gene-set signatures [PDF]

, 2010
MicroRNAs are emerging as important regulators of diverse biological processes and pathologies in animals and plants. Though hundreds of human microRNAs are known, only a few have known functions.
Alexander van Oudenaarden, Ashburner, Bader, Baek, Bartel, Bonci, Bravo-Egana, Burk, Bushati, Calin, Carè, Chan, Chang, Chen, Cheng, Chhabra, Cloonan, Correa-Medina, Esquela-Kerscher, Farh, Gregory, Griffiths-Jones, Grimson, He, Heineke, Ji, Ji, Joachim, Joglekar, John S. Tsang, Johnnidis, Johnson, Jones, Kanehisa, Kefas, Korpal, Krek, Krützfeldt, Kumar, Lewis, Li, Li, Li, Linsley, Liu, Lu, Lu, Margaret S. Ebert, Martinez, Mendell, Miller, Nagai, Park, Pickering, Rajewsky, Raver-Shapira, Ruepp, Sayed, Schultz, Segal, Selbach, Sempere, Siegel, Stark, Storey, Subramanian, Sudhof, Taganov, Tarasov, Thai, Tsang, van Rooij, Ventura, Visvanathan, Webster, Wegman, Xiao, Xie, Yang, Yu, Yu, Zhao   +81 more
core   +1 more source

Adenylyl cyclase 2 expression and function in neurological diseases

CNS Neuroscience &Therapeutics, Volume 30, Issue 7, July 2024.
Mutations and expression changes of adenylyl cyclase 2 (Adcy2), a CNS‐enriched enzyme that converts ATP to cAMP, are associated with several neurodegenerative and psychiatric disorders. Abstract Adenylyl cyclases (Adcys) catalyze the formation of cAMP, a secondary messenger essential for cell survival and neurotransmission pathways in the CNS.
Marsilla Gray, Kevin R. Nash, Yao Yao
wiley   +1 more source

Unveiling blood pressure‐associated genes in aortic cells through integrative analysis of GWAS and RNA modification‐associated variants

Chronic Diseases and Translational Medicine, Volume 10, Issue 2, Page 118-129, June 2024.
Differential expression genes in single‐cell transcriptomic sequencing study. (A) Uniform Manifold Approximation and Projection (UMAP) visualization showcasing distinct immune cell types among six cases and seven controls. (B) Volcano plot displaying differential expression genes between aortic dissection patients and controls.
Huan Zhang, Yuxi Chen, Peng Xu, Dan Liu, Naqiong Wu, Laiyuan Wang, Xingbo Mo   +6 more
wiley   +1 more source

Ciliary adenylyl cyclases control the Hedgehog pathway [PDF]

, 2015
Protein kinase A (PKA) accumulates at the base of the cilium where it negatively regulates the Hedgehog (Hh) pathway. Although PKA activity is essentially controlled by the cAMP produced by adenylyl cyclases, the influence of these enzymes on the Hh ...
Herrera, Antonio, Menendez, Anghara, Pons, Sebastián, Torroba, Blanca, Vuolo, Laura   +4 more
core   +1 more source

Steroid Pathway Genes and Neonatal Respiratory Distress After Betamethasone Use in Anticipated Preterm Birth [PDF]

, 2016
Objective: To test several key glucocorticoid genes that are enhanced in lung development for associations with respiratory distress syndrome (RDS) after antenatal corticosteroid use.
Flockhart, David A., Foroud, Tatiana, Haas, David M., Kho, Alvin, Lai, Dongbing, Sharma, Sunita, Tantisira, Kelan, Then, Jenny   +7 more
core   +1 more source