Results 51 to 60 of about 1,135 (126)

Genome-wide DNA methylation pattern in visceral adipose tissue differentiates insulin-resistant from insulin-sensitive obese subject [PDF]

, 2017
Elucidating the potential mechanisms involved in the detrimental effect of excess body weight on insulin action is an important priority in counteracting obesity-associated diseases.
Casanueva, Felipe F., Crujeiras, Ana B., Diaz-Lagares, Angel, Esteller, Manel, Fernandez-Real, J. M., Gomez, A., Hervas, David, Moreno-Navarrete, José María, Ricart Engel, Wifredo, Sandoval, Juan   +9 more
core   +1 more source

Genetic architecture and selection of Anhui autochthonous pig population revealed by whole genome resequencing

Frontiers in Genetics, 2022
The genetic resources among pigs in Anhui Province are diverse, but their value and potential have yet to be discovered. To illustrate the genetic diversity and population structure of the Anhui pigs population, we resequenced the genome of 150 pigs from
Wei Zhang, Xiaojin Li, Yao Jiang, Mei Zhou, Linqing Liu, Shiguang Su, Chengliang Xu, Xueting Li, Chonglong Wang   +8 more
semanticscholar   +1 more source

POPDC1 scaffolds a complex of adenylyl cyclase 9 and the potassium channel TREK‐1 in heart

EMBO Reports, 2022
The establishment of macromolecular complexes by scaffolding proteins is key to the local production of cAMP by anchored adenylyl cyclase (AC) and the subsequent cAMP signaling necessary for cardiac functions.
Tanya A. Baldwin, Yong Li, Autumn Marsden, S. Rinné, Anibal Garza-Carbajal, R. Schindler, Musi Zhang, Mia A. Garcia, V. Venna, N. Decher, T. Brand, C. Dessauer   +11 more
semanticscholar   +1 more source

Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes [PDF]

, 2015
BACKGROUND - : Cardiovascular disease (CVD) reflects a highly coordinated complex of traits. Although genome-wide association studies have reported numerous single nucleotide polymorphisms (SNPs) to be associated with CVD, the role of most of these ...
Chen, B.H., Courchesne P., Cupples L.A., Fox, C.S., Freedman J.E., Huan, T., Joehanes, R., Keles, S., Levy, D., Liu, C., Meigs J.B., Munson P.J., O'Donnell, C.J., Otlu, B., Tastan O., Yao, C., Zhang X.   +16 more
core   +1 more source

The human intelligence evolved from proximal cis‐regulatory saltations

Quantitative Biology, Volume 13, Issue 2, June 2025.
Abstract The divergence rate between the alignable genomes of humans and chimpanzees is as little as 1.23%. Their phenotypical difference was hypothesized to be accounted for by gene regulation. We construct the cis‐regulatory element frequency (CREF) matrix to represent the proximal regulatory sequences for each species.
Xiaojie Li, Jianhui Shi, Lei M. Li
wiley   +1 more source

Duplications of the critical Rubinstein-Taybi deletion region on chromosome 16p13.3 cause a novel recognisable syndrome [PDF]

, 2010
Background The introduction of molecular karyotyping technologies facilitated the identification of specific genetic disorders associated with imbalances of certain genomic regions.
Bena, F, Bottani, A, Breckpot, J, Cheung, SW, Devriendt, K, Fong, CT, Friedman, JM, Fryns, JP, Gimelli, S, Gorski, JL, Grange, DK, Kussmann, JL, Menten, Björn, Morris, MM, Mortier, Geert, Philip, N, Salamone, JM, Scalais, E, Thienpont, B, Van Esch, H, Vermeesch, JR, Villard, L, Yong, SL, Zahir, F   +23 more
core   +2 more sources

Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice

British Journal of Pharmacology, Volume 182, Issue 5, Page 1143-1163, March 2025.
Abstract Background and Purpose Pneumoconiosis, especially silicosis, is a prevalent occupational disease with substantial global economic implications and lacks a definitive cure. Both pneumoconiosis and idiopathic pulmonary fibrosis (IPF) are interstitial lung diseases, which share many common physiological characteristics.
Lu Bai, Jiaxin Wang, Xue Wang, Jixin Wang, Wei Zeng, Junling Pang, Tiantian Zhang, Shengxi Li, Meiyue Song, Yiwei Shi, Jing Wang, Chen Wang   +11 more
wiley   +1 more source

A forskolin-mediated increase in cAMP promotes T helper cell differentiation into the Th1 and Th2 subsets rather than into the Th17 subset

bioRxiv, 2022
The cyclic adenosine monophosphate (cAMP) signaling pathway is involved in various physiological and pathophysiological processes. Forskolin (FSK), a labdane diterpene well known as an activator of cAMP production, is suggested to possess significant ...
Petra Daďová, Antónia Mikulová, Radim Jaroušek, S. Uldrijan, L. Kubala   +4 more
semanticscholar   +1 more source

Steroidogenesis-related gene expression in the rat ovary exposed to melatonin supplementation [PDF]

, 2015
OBJECTIVE: To analyze steroidogenesis-related gene expression in the rat ovary exposed to melatonin supplementation. METHODS: Thirty-two virgin adult female rats were randomized to two groups as follows: the control group GI received vehicle and the ...
Baracat, Edmund Chada, Baracat, Maria Cândida Pinheiro, Fuchs, Luiz Fernando Portugal, Lima, Gisele Negro, Maganhin, Carla Cristina, Sasso, Gisela Rodrigues da Silva, Simões, Manuel de Jesus, Simões, Ricardo Santos, Soares Júnior, José Maria   +8 more
core   +4 more sources

Insights into RNA‐mediated pathology in new mouse models of Huntington's disease

The FASEB Journal, Volume 38, Issue 23, 15 December 2024.
The behavioral and molecular characterization was performed for Huntington's disease mouse models expressing a fragment of the human HTT gene, with mutation of ~100 CAG repeats, in the nontranslated version (HD/100CAG) and the translated version (HD/100Q). Abstract Huntington's disease (HD) is a neurodegenerative polyglutamine (polyQ) disease resulting
Magdalena Wozna‐Wysocka, Magdalena Jazurek‐Ciesiolka, Lukasz Przybyl, Dorota Wronka, Julia Oliwia Misiorek, Joanna Suszynska‐Zajczyk, Grzegorz Figura, Adam Ciesiolka, Paula Sobieszczanska, Anna Zeller, Magdalena Niemira, Pawel Michal Switonski, Agnieszka Fiszer   +12 more
wiley   +1 more source