Results 71 to 80 of about 2,762 (187)

Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis.

PLoS ONE, 2010
With the functional demonstration of a role in erythrocyte invasion by Plasmodium falciparum parasites, implications in the aetiology of common conditions that prevail in individuals of African origin, and a wealth of pharmacological knowledge, the ...
Sarah Auburn, Andrew E Fry, Taane G Clark, Susana Campino, Mahamadou Diakite, Angela Green, Anna Richardson, Muminatou Jallow, Fatou Sisay-Joof, Margaret Pinder, Malcolm E Molyneux, Terrie E Taylor, Kasturi Haldar, Kirk A Rockett, Dominic P Kwiatkowski   +14 more
doaj   +1 more source

Genome-wide DNA methylation pattern in visceral adipose tissue differentiates insulin-resistant from insulin-sensitive obese subject [PDF]

, 2017
Elucidating the potential mechanisms involved in the detrimental effect of excess body weight on insulin action is an important priority in counteracting obesity-associated diseases.
Casanueva, Felipe F., Crujeiras, Ana B., Diaz-Lagares, Angel, Esteller, Manel, Fernandez-Real, J. M., Gomez, A., Hervas, David, Moreno-Navarrete, José María, Ricart Engel, Wifredo, Sandoval, Juan   +9 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Host candidate gene polymorphisms and clearance of drug-resistant parasites [PDF]

, 2011
Resistance to anti-malarial drugs is a widespread problem for control programmes for this devastating disease. Molecular tests are available for many anti-malarial drugs and are useful tools for the surveillance of drug resistance.
Achidi, EA, Achonduh, O, Craik, R, Diakite, M, Djimde, AA, Evehe, M-SB, Green, A, Hubbart, C, Ibrahim, M, Jeffreys, A, Jezan, SO, Khan, BK, Kimani, F, Kwiatkowski, DP, Mbacham, WF, Ouedraogo, JB, Ranford-Cartwright, LC, Rockett, K, Rowlands, K, Tagelsir, N, Tekete, MM, Zongo, I   +21 more
core   +3 more sources

ADENYLYL CYCLASE TYPE 9: REGULATION AND CARDIAC FUNCTION [PDF]

, 2018
Abnormalities in cardiac stress signaling underlie a number of cardiovascular diseases (e.g. arrhythmias and heart failure). Cardiac stress signaling pathways normally integrate signals from the sympathetic nervous system to promote efficient contraction
Baldwin, Tanya A., Baldwin, Tanya A.
core   +1 more source

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, Volume 182, Issue 19, Page 4625-4646, October 2025.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source

The human intelligence evolved from proximal cis‐regulatory saltations

Quantitative Biology, Volume 13, Issue 2, June 2025.
Abstract The divergence rate between the alignable genomes of humans and chimpanzees is as little as 1.23%. Their phenotypical difference was hypothesized to be accounted for by gene regulation. We construct the cis‐regulatory element frequency (CREF) matrix to represent the proximal regulatory sequences for each species.
Xiaojie Li, Jianhui Shi, Lei M. Li
wiley   +1 more source

Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice

British Journal of Pharmacology, Volume 182, Issue 5, Page 1143-1163, March 2025.
Abstract Background and Purpose Pneumoconiosis, especially silicosis, is a prevalent occupational disease with substantial global economic implications and lacks a definitive cure. Both pneumoconiosis and idiopathic pulmonary fibrosis (IPF) are interstitial lung diseases, which share many common physiological characteristics.
Lu Bai, Jiaxin Wang, Xue Wang, Jixin Wang, Wei Zeng, Junling Pang, Tiantian Zhang, Shengxi Li, Meiyue Song, Yiwei Shi, Jing Wang, Chen Wang   +11 more
wiley   +1 more source

Gene expression within the extended amygdala of 5 pairs of rat lines selectively bred for high or low ethanol consumption [PDF]

, 2013
The objectives of this study were to determine innate differences in gene expression in 2 regions of the extended amygdala between 5 different pairs of lines of male rats selectively bred for high or low ethanol consumption: a) alcohol-preferring (P) vs.
Bell, Richard L., Colombo, Giancarlo, Ding, Zheng-Ming, Edenberg, Howard J., Hyytia, Petri, Kimpel, Mark W., Liang, Tiebing, Lumeng, Lawrence, McBride, William J., McClintick, Jeanette N.   +9 more
core   +2 more sources

Identification of an Efficient Gene Expression Panel for Glioblastoma Classification. [PDF]

, 2016
We present here a novel genetic algorithm-based random forest (GARF) modeling technique that enables a reduction in the complexity of large gene disease signatures to highly accurate, greatly simplified gene panels.
Coppola, Giovanni, Crisman, Thomas J, Gao, Fuying, Kawaguchi, Riki, Kornblum, Harley I, Laks, Dan R, Zelaya, Ivette, Zhao, Yining   +7 more
core   +2 more sources