Results 71 to 80 of about 1,135 (126)
Physiological responses to a changing winter climate in an early spring‐breeding amphibian
Ecology and Evolution, Volume 14, Issue 7, July 2024.Climate change is swiftly altering environmental winter conditions, leading to significant ecological impacts such as phenological shifts in many species. Our study points for the first time to the complex physiological challenges that amphibians face as a result of changing thermal conditions due to winter climate change.
Robin Schmidt +6 more
wiley +1 more source
ADENYLYL CYCLASE TYPE 9: REGULATION AND CARDIAC FUNCTION [PDF]
, 2018 Abnormalities in cardiac stress signaling underlie a number of cardiovascular diseases (e.g. arrhythmias and heart failure). Cardiac stress signaling pathways normally integrate signals from the sympathetic nervous system to promote efficient contraction
Baldwin, Tanya A., Baldwin, Tanya A.
core +1 more source
Identification of an Efficient Gene Expression Panel for Glioblastoma Classification. [PDF]
, 2016 We present here a novel genetic algorithm-based random forest (GARF) modeling technique that enables a reduction in the complexity of large gene disease signatures to highly accurate, greatly simplified gene panels.
Coppola, Giovanni +7 more
core +2 more sources
Adenylyl cyclase 2 expression and function in neurological diseases
CNS Neuroscience &Therapeutics, Volume 30, Issue 7, July 2024.Mutations and expression changes of adenylyl cyclase 2 (Adcy2), a CNS‐enriched enzyme that converts ATP to cAMP, are associated with several neurodegenerative and psychiatric disorders. Abstract Adenylyl cyclases (Adcys) catalyze the formation of cAMP, a secondary messenger essential for cell survival and neurotransmission pathways in the CNS.
Marsilla Gray, Kevin R. Nash, Yao Yao
wiley +1 more source
Epstein-Barr Virus EBER Transcripts Affect miRNA-Mediated Regulation of Specific Targets and Are Processed to Small RNA Species [PDF]
, 2015 The oncogenic Epstein-Barr virus (EBV) expresses 44 mature microRNAs and two non-coding EBER RNAs of 167 (EBER1) and 172 (EBER2) nt length. MiRNA profiling of NK/T cell lines and primary cells and Northern blotting of EBV-infected cell lines and primary ...
Alles, J. +4 more
core +1 more source
Chronic Diseases and Translational Medicine, Volume 10, Issue 2, Page 118-129, June 2024.Differential expression genes in single‐cell transcriptomic sequencing study. (A) Uniform Manifold Approximation and Projection (UMAP) visualization showcasing distinct immune cell types among six cases and seven controls. (B) Volcano plot displaying differential expression genes between aortic dissection patients and controls.
Huan Zhang +6 more
wiley +1 more source
Social threat exposure in juvenile mice promotes cocaine-seeking by altering blood clotting and brain vasculature [PDF]
, 2016 Childhood maltreatment is associated with increased severity of substance use disorder and frequent relapse to drug use following abstinence. However, the molecular and neurobiological substrates that are engaged during early traumatic events and ...
Aricò, Eleonora +11 more
core +1 more source
DNA methylation and transcriptome analysis reveal epigenomic differences among three macaque species
Evolutionary Applications, Volume 17, Issue 2, February 2024.Abstract Macaques (genus Macaca) are the most widely distributed non‐human primates, and their evolutionary history, gene expression profiles, and genetic differences have been extensively studied. However, the DNA methylomes of macaque species are not available in public databases, which hampers understanding of epigenetic differences among macaque ...
Jiao Wang +6 more
wiley +1 more source
Pharmacogenomics of blood lipid regulation [PDF]
, 2018 Blood lipids are important modifiable risk factors for coronary heart disease and drugs target different lipid fractions. Considerable efforts have been made to identify genetic variants that modulate responses to drugs in the hope of optimizing their ...
Dubé, Marie-Pierre +2 more
core +1 more source