Results 71 to 80 of about 2,141 (173)

Ulk4 regulates GABAergic signaling and anxiety-related behavior [PDF]

, 2018
Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene encoding a putative Serine ...
A Cooper, A Hogart, A Lippa, A MacKenzie-Graham, A Marowsky, A Paydar, A Viggiano, AA Walf, AM Addington, B Burns, B Lang, B Lang, CB Nemeroff, CR Marshall, D Azzinnari, D Bosch, D Pinto, D Rujescu, DA Lewis, DM Kerr, DM Kerr, G Fenalti, G Kirov, GJ Qu, HU Wittchen, JJ Nadler, JJ Soghomonian, JN Crawley, JT Glessner, K Njunge, KD Micheva, KV Barnes, KV Sandhu, L Dominguez, LW Jin, M Liu, M Liu, M Seney, MJ Millan, MR Zarrindast, O Stork, P Muglia, PG Unschuld, RB Lydiard, RMJ Deacon, S Chung, S Heckers, S Muhie, SA Heldt, SF Kash, T Hashimoto, T Toyota, WC Skarnes, WF Schwindinger, WH Chou, Y Gonchar   +55 more
core   +3 more sources

Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice

British Journal of Pharmacology, Volume 182, Issue 5, Page 1143-1163, March 2025.
Abstract Background and Purpose Pneumoconiosis, especially silicosis, is a prevalent occupational disease with substantial global economic implications and lacks a definitive cure. Both pneumoconiosis and idiopathic pulmonary fibrosis (IPF) are interstitial lung diseases, which share many common physiological characteristics.
Lu Bai, Jiaxin Wang, Xue Wang, Jixin Wang, Wei Zeng, Junling Pang, Tiantian Zhang, Shengxi Li, Meiyue Song, Yiwei Shi, Jing Wang, Chen Wang   +11 more
wiley   +1 more source

Insights into RNA‐mediated pathology in new mouse models of Huntington's disease

The FASEB Journal, Volume 38, Issue 23, 15 December 2024.
The behavioral and molecular characterization was performed for Huntington's disease mouse models expressing a fragment of the human HTT gene, with mutation of ~100 CAG repeats, in the nontranslated version (HD/100CAG) and the translated version (HD/100Q). Abstract Huntington's disease (HD) is a neurodegenerative polyglutamine (polyQ) disease resulting
Magdalena Wozna‐Wysocka, Magdalena Jazurek‐Ciesiolka, Lukasz Przybyl, Dorota Wronka, Julia Oliwia Misiorek, Joanna Suszynska‐Zajczyk, Grzegorz Figura, Adam Ciesiolka, Paula Sobieszczanska, Anna Zeller, Magdalena Niemira, Pawel Michal Switonski, Agnieszka Fiszer   +12 more
wiley   +1 more source

A forskolin-mediated increase in cAMP promotes T helper cell differentiation into the Th1 and Th2 subsets rather than into the Th17 subset

bioRxiv, 2022
The cyclic adenosine monophosphate (cAMP) signaling pathway is involved in various physiological and pathophysiological processes. Forskolin (FSK), a labdane diterpene well known as an activator of cAMP production, is suggested to possess significant ...
Petra Daďová, Antónia Mikulová, Radim Jaroušek, S. Uldrijan, L. Kubala   +4 more
semanticscholar   +1 more source

Drivers of genomic diversity and phenotypic development in early phases of domestication in Hermetia illucens

Insect Molecular Biology, Volume 33, Issue 6, Page 756-776, December 2024.
Random drift rather than selection is the primary evolutionary force driving genomic and phenotypic variation in BSF populations during early phases of domestication. Functional trade‐offs between production and fitness traits were observed in BSF populations.
Kelvin L. Hull, Matthew P. Greenwood, Melissa Lloyd, Marissa Brink‐Hull, Aletta E. Bester‐van der Merwe, Clint Rhode   +5 more
wiley   +1 more source

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition [PDF]

, 2014
BRAFV600E-mutant malignant melanomas depend on RAF/MEK/ERK (MAPK) signaling for tumor cell growth1. RAF and MEK inhibitors show remarkable clinical efficacy in BRAFV600E melanoma2, 3; however, resistance to these agents remains a formidable challenge2, 4.
Donahue, Melanie K., Flaherty, Keith T., Frederick, Dennie T., Garraway, Levi A., Johannessen, Cory M., Johnson, Laura A., Narayan, Rajiv, Piccioni, Federica, Root, David E., Townes, Aisha, Wargo, Jennifer A.   +10 more
core   +1 more source

Paraoxonase‐2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non‐alcoholic steatohepatitis

British Journal of Pharmacology, Volume 181, Issue 19, Page 3717-3742, October 2024.
Abstract Background and Purpose Only limited therapeutic agents have been developed for non‐alcoholic steatohepatitis (NASH). Glabridin, a promising anti‐obesity candidate, has only limited druggability due to its low in vivo chemical stability and bioavailability.
Gu‐Choul Shin, Hyeong Min Lee, Nayeon Kim, Jihyeon Hur, Sang‐Ku Yoo, Yun Sun Park, Hyung Soon Park, Dongryeol Ryu, Min‐Ho Park, Jung Hee Park, Sang‐Uk Seo, Leo Sungwong Choi, Martin Rønn Madsen, Michael Feigh, Kwang Pyo Kim, Kyun‐Hwan Kim   +15 more
wiley   +1 more source

Integration of multiomics data identifies candidate genes influencing pH levels in Beijing Black pigs

Animal Research and One Health, Volume 2, Issue 3, Page 260-272, August 2024.
To explore the genetic mechanism of pH values, we measured the pH values at 2 h (pH2h) and 24 h (pH24h) postmortem in the longissimus dorsi muscle of Beijing Black pigs. A total of 614 Beijing Black pigs were genotyped by the Illumina Porcine 50K SNP Chip. We conducted a genome‐wide association study and RNA sequencing (RNA‐seq) analysis.
Jingjing Tian, Naiqi Niu, Xiaoqing Wang, Liangyu Shi, Liyu Yang, Mianyan Li, Lijun Shi, Xin Liu, Hongmei Gao, Xinhua Hou, Ligang Wang, Lixian Wang, Longchao Zhang, Fuping Zhao   +13 more
wiley   +1 more source

Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants

BioMed Research International, 2022
Background Childhood overweight and obesity (OW/OB) is a worldwide public health problem, and its genetic risks remain unclear. Objectives To investigate risks of OW/OB associated with genetic variances in SEC16B rs543874 and rs10913469, BDNF rs11030104 ...
Hong Mei, Bao Yin, Wenhong Yang, Jingli Zhang, Hongyan Lu, Xiaobin Qi, Wenhua Mei, Hongzhong Zhang, Jianduan Zhang   +8 more
semanticscholar   +1 more source

Study on the characteristics of physiological parameters and liver transcriptomes on production and methane emission during the fattening period in Japanese Black cattle [PDF]

, 2022
Tohoku University博士（農学）博士学位論文 (Thesis(doctor ...
金, 民知
core