Results 111 to 120 of about 2,720,797 (300)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Added wave resistance prediction and comparative study based on point cloud feature extraction

Zhongguo Jianchuan Yanjiu
ObjectiveIn order to rapidly forecast added wave resistance in the ship design stage, this paper proposes a neural network based on point cloud feature extraction.
Mingfeng WU, Renchuan ZHU, Dekang XU
doaj   +1 more source

Taming the Floods: Using an Intellectual History of Chinese Hydraulic Thought to Address Contemporary Issues in China’s Water Governance [PDF]

, 2018
China’s current hydraulic systems are in a state of atrophy, caused by sustained damage over centuries to infrastructure that has changed very little. Added to an already weak infrastructure is a relatively new crisis of water scarcity, which is forcing ...
Danison, Sophia Rose
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Numerical investigation of added resistance of a container ship in short regular waves using unsteady RANS simulations

Brodogradnja
Accurately predicting the added resistance coefficient in short waves remains a challenge. This study aims to investigate the added resistance of a container ship in regular short-head waves at moderate Froude numbers through unsteady RANS simulations. A
Paresh Halder, Shukui Liu
doaj   +1 more source

Resistance of Josephson Junction Arrays at Low Temperatures

, 1997
We study motion of vortices in arrays of Josephson junctions at zero temperature where it is controlled by quantum tunneling from one plaquette to another.
A. F. Hebard, A. I. Larkin, A. O. Caldeira, A. van Otterlo, B. N. Narozhny, C. L. Kane, D. R. Nelson, H. S. J. van der Zant, H. S. J. van der Zant, J. Bardeen, J. E. Mooij, L. B. Ioffe, M. A. Itzler, M. P. A. Fisher, R. Fazio, S. E. Korshunov, T. P. Orlando, U. Eckern, U. Eckern, U. Eckern, U. Geigenmüller, U. Geigenmüller, V. M. Bedanov, Y. Nambu   +23 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Data-driven modeling and regression analysis on ship resistance of in-service performance

International Journal of Naval Architecture and Ocean Engineering
This study employs operational data to model ship resistance, aiming to bridge the gap between controlled experiments and real-world conditions. It comprehensively analyzes wind, waves, and currents, employing nonlinear regression and z-score filtering ...
Daehyuk Kim, Shin Hyung Rhee
doaj   +1 more source