Results 91 to 100 of about 1,092,692 (265)

Effect of STEP for Reducing Added Resistance in Waves

Journal of the Japan Society of Naval Architects and Ocean Engineers, 2011
The present paper provides the results of an investigation on STEP (Spray Tearing Plate) for reducing the added resistance in waves.The research has been started to develop a device for suppressing spray; thin wave like a film that is generated around the bow above the waterline when a ship runs in waves.
Mariko Kuroda, Masaru Tsujimoto, Noriyuki Sasaki, Masakazu Omote, Nobuo Nojima, Masato Kaga   +5 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Added wave resistance prediction and comparative study based on point cloud feature extraction

Zhongguo Jianchuan Yanjiu
ObjectiveIn order to rapidly forecast added wave resistance in the ship design stage, this paper proposes a neural network based on point cloud feature extraction.
Mingfeng WU, Renchuan ZHU, Dekang XU
doaj   +1 more source

Effect of Graphene on Micro-Structure and Properties of MAO Coating Prepared on Mg-Li Alloy

International Journal of Electrochemical Science, 2017
Ceramic coating modified with graphene was formed on Mg-Li alloy by a micro-arc oxidation process in a graphene powders (GE) added silicate electrolyte. The microstructure, composition, tribological and corrosion behaviors of the coatings were performed.
Fei Chen, Yulin Zhang, You Zhang
doaj   +1 more source

Electrical Resistivity of α-SiC Ceramics Added with NiO

Journal of the Ceramic Society of Japan, 1994
Temperature dependence of electrical resistivity has been investigated for α-SiC ceramics added with transition metal oxides in order to develop a heating element, whose electrical resistivity is positive or constant against temperature up to 400°C.
HASHIGUCHI, Hideto, KINUGASA, Hisashi
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Numerical investigation of added resistance of a container ship in short regular waves using unsteady RANS simulations

Brodogradnja
Accurately predicting the added resistance coefficient in short waves remains a challenge. This study aims to investigate the added resistance of a container ship in regular short-head waves at moderate Froude numbers through unsteady RANS simulations. A
Paresh Halder, Shukui Liu
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source