Results 71 to 80 of about 1,096,822 (266)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

AD - AN insulin resistant brain state

open access: yesJournal of neural transmission, 2008
Reports of impaired brain insulin receptor (IR) signaling being involved in cognitive decline, affecting also glucose utilization and energy metabolism, cell growth and differentiation, as well as metabolism of amyloid beta (Aβ ) and tau protein, have drawn an increasing attention in Alzheimer’ s disease (AD) research.
Šalković-Petrišić, Melita   +4 more
openaire   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

The effect of added O_2 on the transmittance and radiation resistance of radiation resistant glasses

open access: yesOptics Express, 2010
One method of hardening optical glasses against radiation-induced darkening has been to add CeO(2) to the batch composition. In the present investigation we prepared a series of lanthanum crown glasses with varying degrees of CeO(2) additions and melted them at 1,400 °C with and without bubbling oxygen gas.
Li, Weinan, Lu, Min
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Multi-Branch Artificial Neural Network-Based Decomposition of Ship’s Added Resistance Using On-Board Measured Data

open access: yesIEEE Access
Prediction and management of ship resistance in realistic sea conditions can play a significant role in reducing fuel consumption and carbon emissions. It usually relies on physical model testing and empirical formulas, both facing limitations in early ...
Nur Assani   +3 more
doaj   +1 more source

Numerical Analysis of Effects of Arms with Different Cross-Sections on Straight-Bladed Vertical Axis Wind Turbine

open access: yesEnergies, 2019
Most vertical axis wind turbines (VAWTs) need arms connecting the blades with the rotational axis. The arms increase the power loss of VAWTs; however, the distribution between the pressure and friction influences and their degrees of influence have not ...
Yutaka Hara   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

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