Results 61 to 70 of about 4,479,240 (304)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Analysis of Added Resistance in Short Waves

Journal of the Society of Naval Architects of Korea, 2015
In this study, the added resistance of ships in short waves is systematically studied by using two different numerical methods - Rankine panel method and Cartesian grid method - and existing asymptotic and empirical formulae. Analysis of added resistance in short waves has been preconceived as a shortcoming of numerical computation.
Kyung-Kyu Yang, Min-Guk Seo, Yonghwan Kim   +2 more
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Milwaukee, Wisconsin 2023

, 2023
Covenants mapped as of Mar. 2 2023Other title Milwaukee County racial covenants, early results Notes This map shows the progress to date of the Mapping Racism and Resistance project in identifying housing deeds that included racial covenants.
Mapping Racism and Resistance
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

An eQTL analysis of partial resistance to Puccinia hordei in barley [PDF]

, 2010
Background - Genetic resistance to barley leaf rust caused by Puccinia hordei involves both R genes and quantitative trait loci. The R genes provide higher but less durable resistance than the quantitative trait loci. Consequently, exploring quantitative
Hackett, Christine A, Vels, S.A., Ramsay, L., Thierry C Marcel, Milne, I., Hedley, Peter E., Druka, Arnis, Booth, C., Luke Ramsay, Marshall, David, Hedley, P.E., Cardle Linda, Marcel, Thierry C., Marcel, Thierry, T., Cardle, Linda, Linda Cardle, Ramsay, Luke, Anton Vels, Hedley Peter E., Marshall, D., Druka Arnis, Hackett Christine A., Milne, Iain, Waugh, R., Milne Iain, Xinwei Chen, Niks, R.E., Vels Anton, Booth Clare, Ramsay Luke, Bayer Micha, Druka, A., Clare Booth, Cardle, L., Marcel Thierry C., Christine A Hackett, Booth, Clare, Waugh, Robbie; id_orcid, Chen, Xinwei, Niks Rients E., Rients E Niks, Hackett, C.A., Milne, Lain, Vels, Anton, Iain Milne, Peter E Hedley, Marcel, T.C., Arnis Druka, Bayer, M., Morris, J., Morris Jenny, Marcel, Thierry, Micha Bayer, Robbie Waugh, Bayer, Micha, Hedley, Peter E, Chen Xinwei, Hackett, Christine A., Waugh, Robbie, Waugh Robbie, Jenny Morris, David Marshall, Niks, Rients E., Niks, Rients E, Marshall David, Morris, Jenny   +65 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Increase of the Ship Fuel Consumption Due to Added Resistance in Waves

Journal of Sustainable Development of Energy, Water and Environment Systems, 2017
Added resistance in waves is the second-order steady force dependant on the ship motions. It significantly affects ship operability and cause speed loss. Therefore the required power and fuel consumption of a ship advancing in a seaway are increasing. In
Nastia Degiuli, Ivan Ćatipović, Ivana Martić, Andreja Werner, Većeslav Čorić   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Antimicrobial drug use and resistance in Europe [PDF]

, 2008
Our study confronts the use of antimicrobial agents in ambulatory care with the resistance trends of 2 major pathogens, Streptococcus pneumoniae and Escherichia coli, in 21 European countries in 2000–2005 and explores whether the notion that ...
Grundmann, Hajo, Goossens, Herman, Ferech, Matus, Zarb, Peter, Sande-Bruinsma, Nienke van de, Verloo, Didier, Tiemersma, Edine, Monen, Jos, European Antimicrobial Resistance Surveillance System and European Surveillance of Antimicrobial Consumption Project Groups   +8 more
core   +1 more source