Results 51 to 60 of about 1,092,692 (265)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Alternative Empirical Formula for Predicting the Frictional Drag Penalty due to Fouling on the Ship Hull using the Design of Experiments (DOE) Method

open access: yesInternational Journal of Technology, 2021
Biofouling is known as one of the main problems in the maritime sector because it can increase the surface roughness of the ship’s hull, which will increase the hull’s frictional resistance  and consequently, the ship’s fuel consumption and
Muhammad Luqman Hakim   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Preparation of Polyester/ Micro Eggshell Fillers Composite as Natural Surface Coating

open access: yesIbn Al-Haitham Journal for Pure and Applied Sciences, 2023
To fabricate an inexpensive surface coating with excellent mechanical properties with good water resistance and thermal diffusion, white eggshell fibers with particle size (~1micrometer) has been added by different weight percentages (1,2,3,4,5,6,7 and 8
Aveen N. Jassim, Widad H. Jassim
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The fructose–copper connection: Added sugars induce fatty liver and insulin resistance via copper deficiency

open access: yesJournal of Metabolic Health, 2018
Background: Evidence suggests that the overconsumption of added sugars can induce fatty liver disease and insulin resistance. Aim: To propose a hypothesis that added sugars induce copper deficiency which can lead to hepatic iron overload, fatty liver ...
James J. DiNicolantonio   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Approximating the Added Resistance Coefficient for a Bulk Carrier Sailing in Head Sea Conditions Based on its Geometrical Parameters and Speed

open access: yesPolish Maritime Research, 2016
The article presents the mathematical function to calculate the added wave resistance transfer function for bulk carriers. Based on this function, the statistical mean added wave resistance generated by an irregular head wave with arbitrary statistical ...
Cepowski Tomasz
doaj   +1 more source

Durability of Concrete With Coal Gasification Slag and Coal Gangue Powder

open access: yesFrontiers in Materials, 2022
Lack and quality decrease of supplementary cementing materials (SCMs) such as fly ash and granulated blast-furnace slag is increasingly prominent in China.
Xiaoliang Zhu   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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