Results 81 to 90 of about 1,096,822 (266)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Effect of STEP for Reducing Added Resistance in Waves

Journal of the Japan Society of Naval Architects and Ocean Engineers, 2011
The present paper provides the results of an investigation on STEP (Spray Tearing Plate) for reducing the added resistance in waves.The research has been started to develop a device for suppressing spray; thin wave like a film that is generated around the bow above the waterline when a ship runs in waves.
Mariko Kuroda, Masaru Tsujimoto, Noriyuki Sasaki, Masakazu Omote, Nobuo Nojima, Masato Kaga   +5 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Effect of Graphene on Micro-Structure and Properties of MAO Coating Prepared on Mg-Li Alloy

International Journal of Electrochemical Science, 2017
Ceramic coating modified with graphene was formed on Mg-Li alloy by a micro-arc oxidation process in a graphene powders (GE) added silicate electrolyte. The microstructure, composition, tribological and corrosion behaviors of the coatings were performed.
Fei Chen, Yulin Zhang, You Zhang
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Numerical investigation of added resistance of a container ship in short regular waves using unsteady RANS simulations

Brodogradnja
Accurately predicting the added resistance coefficient in short waves remains a challenge. This study aims to investigate the added resistance of a container ship in regular short-head waves at moderate Froude numbers through unsteady RANS simulations. A
Paresh Halder, Shukui Liu
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Added wave resistance prediction and comparative study based on point cloud feature extraction

Zhongguo Jianchuan Yanjiu
ObjectiveIn order to rapidly forecast added wave resistance in the ship design stage, this paper proposes a neural network based on point cloud feature extraction.
Mingfeng WU, Renchuan ZHU, Dekang XU
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source