Results 121 to 130 of about 2,720,797 (300)

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Use of genetic resources and partial resistances for apple breeding [PDF]

, 2006
Modern apple breeding strategies are mainly considering the most advanced selections and culti-vars as parents. This tends to lead to a narrowed genetic basis.
Duffy, Brion, Kellehals, Markus
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Neomycin resistance as a dominant selectable marker for selection and isolation of vaccinia virus recombinants [PDF]

, 1985
The antibiotic G418 was shown to be an effective inhibitor of vaccinia virus replication when an appropriate concentration of it was added to cell monolayers 48 h before infection. Genetic engineering techniques were used in concert with DNA transfection
Franke, Christine A., Hruby, Dennis E., Rice, Charles M., Strauss, James H.   +3 more
core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

A numerical study of added resistance performance and hydrodynamics of KCS hull in oblique regular waves and estimation of resistance in short-crested irregular waves through spectral method

International Journal of Naval Architecture and Ocean Engineering
Research on multidirectional waves is increasing as studies on added resistance advance. In this study, the added resistance of the multidirectional regular waves of the KCS hull was estimated by numerical analysis.
Soon-Hyun Lee, Cheolho Kim, Kwang-Jun Paik, Hyeongjun Kim, Jangho Chun   +4 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

ADDED RESISTANCE IN WAVES OF INTACT AND DAMAGED SHIP IN THE ADRIATIC SEA

Brodogradnja, 2015
In this paper the ship added resistance in regular head waves and at different sea states in a certain frequency range at different forward speeds was calculated. Calculations were conducted using hydrodynamic software.
Ivana Martić, Nastia Degiuli, Ivan Ćatipović   +2 more
doaj  

Computational Fluid Dynamics Analysis into the Comparison of Resistance Characteristics Between DARPA Suboff and Modified U209 Types of Submarines

Sci
Submarines are required to have good performance, which is influenced by their type of hull, hull conditions, and operational conditions. This study compares the resistance between a Modified-U209 (U209) submarine and the DARPA Suboff.
Ahmad Nasirudin, Sutiyo, Ardi Nugroho Yulianto, Eko Julianto, I Ketut Aria Pria Utama, Martin Renilson   +5 more
doaj   +1 more source