Results 41 to 50 of about 35,531 (288)

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

NUMERICAL STUDY ON PROPULSIVE FACTORS IN REGULAR HEAD AND OBLIQUE WAVES

Brodogradnja, 2022
This paper applies Reynolds-averaged Navier-Stokes (RANS) method to study propulsion performance in head and oblique waves. Finite volume method (FVM) is employed to discretize the governing equations and SST k-ω model is used for modeling the turbulent ...
Kun Dai, Yunbo Li, Jiaye Gong, Zheng Fu, Ang Li, Dapeng Zhang   +5 more
doaj   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Model propulsion tests in head and following waves of a bulk carrier

Applied Ocean Research
The results of self-propulsion measurements in calm water and regular head and following waves, under different propeller loading conditions, are presented.
Sverre Steen, Adrian Portillo-Juan, Simone Saettone   +2 more
doaj   +1 more source

Application of the Design of Experiments and Computational Fluid Dynamics to Bow Design Improvement

Journal of Marine Science and Engineering, 2019
Techniques of the design of experiments (DOE) and computational fluid dynamics (CFD) were applied for improving the bow shape of a tanker hull. Through this, a hull that could reduce the added resistance in waves was derived.
Woochan Seok, Gwan Hoon Kim, Jeonghwa Seo, Shin Hyung Rhee   +3 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Experimental and Numerical Resistance Analysis for a Cruise Ship W/O Fin Stabilizers

Journal of Marine Science and Engineering, 2022
Applying fin stabilizers is an effective solution for ship rolls on waves in a seaway. They generally consist of one or two pairs of retractable fins that are symmetrically mounted to both sides of the ship, effectively reducing the roll motion at low or
Rulin Yao, Long Yu, Qidong Fan, Xuefeng Wang   +3 more
doaj   +1 more source

Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier, Ugo Sorrentino, Matias Wagner, Marta Zawadzka, Anna Lemska, Maria Mazurkiewicz‐Bełdzińska, Michael Zech   +6 more
wiley   +1 more source

Analysis of added resistance and seakeeping responses in head sea conditions for low-speed full ships using URANS approach

International Journal of Naval Architecture and Ocean Engineering, 2017
The KVLCC2 and its modified hull form were investigated in regular head waves using Unsteady Reynolds Averaged Navier–Stokes (URANS) methods. The modified KVLCC2 (named KWP-bow KVLCC2) is designed for reducing wave reflection from the bow.
Yoo-Chul Kim, Kwang-Soo Kim, Jin Kim, Yoonsik Kim, Il-Ryong Park, Young-Hun Jang   +5 more
doaj   +1 more source

Application of wave added resistance calculation method in comprehensive optimization design of ship hull form

Zhongguo Jianchuan Yanjiu, 2020
Objectives In order to obtain a good hull form with both static water and wave resistance performance, a bulk carrier is taken as the research object to carry out the comprehensive optimization design of the hull form.Methods The evaluation of the static
MENG Qiao, QU Yuan, CHEN Ling
doaj   +1 more source