Results 111 to 120 of about 926,997 (405)
Recent Methods for Measuring Dopamine D3 receptor Occupancy In Vivo: Importance for Drug Development
Frontiers in Pharmacology, 2014 There is considerable interest in developing highly selective dopamine D3 receptor ligands for a variety of mental health disorders. Dopamine D3 receptors have been implicated in Parkinson’s Disease, schizophrenia, anxiety, depression, and substance use ...
Bernard eLe Foll +17 more
doaj +1 more source
Substance Abuse Treatment, Prevention, and Policy, 2020 Background Opioid dependence carries the highest disease burden of all illicit drugs. Opioid agonist therapy (OAT) is an evidence-based medical intervention that reduces morbidity and mortality. There is limited knowledge on the health-related quality of
Christer Frode Aas +10 more
doaj +1 more source
International Journal of Environmental Research and Public Health, 2020 The coronavirus disease 2019 (COVID-19) outbreak has significantly disrupted normal activities globally. During this epidemic, people around the world were expected to encounter several mental health challenges.
Min-Pei Lin
semanticscholar +1 more source
Frontiers in Psychiatry, 2013 Classification of behavioral disturbances should be done by carefully considering the boundaries between physiology (normality) and pathology (disease), irrespective of social context. The following considerations will highlight some of the objectivable changes observed in the brains of animals and humans who underwent repetitive use of addicting ...
openaire +3 more sources
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Sex Addiction: the Chicken-and-Egg Dilemma of Diagnosis [PDF]
, 2013 In May 2013, the American Psychiatric Association will release the next version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V). Interestingly, sex addiction, despite significant attention from mainstream media, will be omitted from ...
Berry, MD
core
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
TrialsBackground There is a lack of knowledge on effective treatment methods for comorbid benzodiazepine dependence in populations undergoing opioid agonist treatment (OAT).
Fatemeh Chalabianloo +17 more
doaj +1 more source
Gambling addiction and life meaning
, 1999 Addictive Gambling has plagued mankind for thousands of years. However, it has only recently been studied extensively. One proposed cause for addiction, which has been used in studying alcohol and drug abuse, is a lack of meaning in the addict\u27s life.
Plesh, Andrew Bohdan
core +1 more source
Prevalence and predictors of video game addiction: a study based on a national representative sample of gamers [PDF]
, 2015 Video gaming has become a popular leisure activity in many parts of the world, and an increasing number of empirical studies examine the small minority that appears to develop problems as a result of excessive gaming.
C Hagquist +39 more
core +1 more source