Results 81 to 90 of about 5,652,944 (334)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Orientation‐Dependent Phase Transformation Pathways Enabling Superior Superelastic and Elastocaloric Performance of NiTi Alloys

Advanced Science, EarlyView.
By integrating simulations and experiments, the preferred (001) crystallographic texture promotes reversible martensite formation through variant selection, enhancing both superelastic and elastocaloric performance. This work provides fundamental guidelines for designing high‐efficiency NiTi‐based functional materials. Abstract Developing elastocaloric
Jiaqi Lu, Muhammad Aziz, Hao Li, Chi Zhang, Zhifeng Huang, Fei Chen   +5 more
wiley   +1 more source

Triangular relationship among risky sexual behavior, addiction, and aggression: A systematic review

Electronic Physician, 2017
Background: Risky sexual behavior (RSB), addiction, and aggression are three important personal and social factors which influence each other. Objective: To overview the potential relationship among RSB, addiction, and aggression to conduct an ...
Khodabakhsh Ahmadi, Seyed Alireza Javadinia, Seyed Hassan Saadat, Mohammad Arash Ramezani, Homa Sedghijalal   +4 more
doaj   +1 more source

Decoding Proton‐Coupled Electron Transfer Mechanism of Nicotine for Multi‐Scenario Portable Electrochemical Sensing

Advanced Science, EarlyView.
A key challenge in nicotine electroanalysis is the unresolved complexity of its interface process, which directly determines sensor metrics. Herein, the proton‐coupled electron transfer mechanism of nicotine is decoded for multi‐scenario portable electrochemical sensing.
Yi Peng, Qinyi Cao, Qianyu Shen, Yuhang Zhang, Shiyu Hu, Hongdou Yi, Qian Liu, Lihui Ou, Qiang Li, Zhaohong Su   +9 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Cytoplasmic Polyadenylation Element Binding Proteins CPEB1 and CPEB3 Regulate the Translation of FosB and Are Required for Maintaining Addiction-Like Behaviors Induced by Cocaine

Frontiers in Cellular Neuroscience, 2020
A recurrent and devastating feature of addiction to a drug of abuse is its persistence, which is mediated by maladaptive long-term memories of the highly pleasurable experience initially associated with the consumption of the drug. We have recently found
Bettina Drisaldi, Luca Colnaghi, Amir Levine, YanYou Huang, Anna M. Snyder, Daniel J. Metzger, Martin Theis, Denise B. Kandel, Denise B. Kandel, Eric R. Kandel, Eric R. Kandel, Eric R. Kandel, Eric R. Kandel, Luana Fioriti, Luana Fioriti, Luana Fioriti   +15 more
doaj   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Influence of anxious attachment on the relationship between primary emotions and substance-related addictive behaviors

Frontiers in Public Health
ObjectivesTo date there is no universally accepted model that describes the development of substance related addictive behavior. In order to address this gap, the study sought to examine whether the association between primary emotions and the ...
Jürgen Fuchshuber, Jürgen Fuchshuber, Jürgen Fuchshuber, Deborah Andres, Theresa Prandstätter, Lisa Roithmeier, Beate Schmautz, Andreas Schwerdtfeger, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer   +12 more
doaj   +1 more source

Rapid and Direct Detection of Methamphetamine in Biofluids using a MXene‐Enabled Electrochemical Sensor

Advanced Science, EarlyView.
A MXene‐enhanced electrochemical sensor enables the rapid and direct detection of methamphetamine. Molecular simulations reveal that specific MXene surface functional groups act as key signal amplifiers by facilitating interfacial interactions. The sensor demonstrates high sensitivity and robust performance in complex biological matrices.
Ri Wang, Xiaofei Deng, Bo Chen, Jienan Shen, Wei Xu, Yingjie Zhu, Yi Zhang, Hui Yang   +7 more
wiley   +1 more source

Review of: "The HERMESS model for addictive behaviors recovery" [PDF]

, 2023
Natalie Winicov
openalex   +3 more sources