Results 121 to 130 of about 881,399 (312)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Appraisal Using Generalized Additive Models [PDF]

Many of the results from real estate empirical studies depend upon using a correct functional form for their validity. Unfortunately, common parametric statistical tools cannot easily control for the possibility of misspecification.
R. Kelley Pace
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Additive Manufacturing: Prospects and Diverse Applications

Additive manufacturing (AM), also known as 3D printing, has emerged as a transformative technology in various industries, providing unprecedented design freedom and customized manufacturing solutions.
Zeyuan Li, Minghao Li, Hulong Ruan, Junjun Wang, Lina Chen, Qixing Jia, Chenglong Yu   +6 more
core   +1 more source

Une méthodologie de conception pour la fabrication additive [PDF]

, 2011
Résumé - Les méthodologies de Design for Assembly et de Design for Manufacturing visent à rendre les produits plus faciles à fabriquer et à assembler en se basant sur les caractéristiques des procédés actuels de fabrication, toutefois ces ...
RODRIGUE, Hugo, CALATORU, Victor, RICHIR, Simon, RIVETTE, Mickaël   +3 more
core  

Additive manufacturing as a platform for introducing cyber-physical services

, 2018
Additive manufacturing (AM) is increasingly used for the production of functional components. This process is based on digital design model and can produce customized components with no additional cost (toolless process).
Holmström, Jan, Khajavi, Siavash H., Baumers, Martin   +2 more
core   +1 more source

Electron Beam Additive Manufacturing of SS316L with a Stochastic Scan Strategy: Microstructure, Texture Evolution, and Mechanical Properties

Metals
This study examines the microstructure, crystallographic texture evolution, and mechanical properties of stainless steel 316L fabricated through electron beam melting using a stochastic scan strategy at a preheat temperature of 1123 K.
K. N. Chaithanya Kumar, Shashank Sharma, Madhavan Radhakrishnan, Rohit Randhavan, Krishna Kamlesh Verma, Shelden Dowden, Zane Weldon Hughes, Rajarshi Banerjee, Narendra B. Dahotre   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Model selection in generalised structured additive regression models [PDF]

, 2007
In recent years data sets have become increasingly more complex requiring more flexible instruments for their analysis. Such a flexible instrument is regression analysis based on a structured additive predictor which allows an appropriate modelling for ...
Belitz, Christiane
core  

In situ observation and reduction of hot-cracks in laser additive manufacturing

Communications Materials
Cracking during Laser Additive Manufacturing is a problem for many higher-strength aluminium alloys, including AA6061. Here, we used a pulsed laser with ramp-down power modulation to improve the cracking resistance by about 50% compared to the use of a ...
Yunhui Chen, Duyao Zhang, Patrick O’Toole, Dong Qiu, Marc Seibold, Klaus. Schricker, Jean-Pierre Bergmann, Alexander Rack, Mark Easton   +8 more
doaj   +1 more source