Results 171 to 180 of about 71,329 (302)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Hydration-stable PVA-based skin phantom for wearable biopotential sensor evaluation. [PDF]

Sci Rep
Lin R, Gonzaga M, Lewis CL, Goyal K.
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

CEU Preferences and Dynamic Consistency [PDF]

This paper investigates the dynamic consistency of CEU preferences. A decision maker is faced with an information structure represented by a fixed filtration.
Kelsey, David, Grant, Simon, Eichberger, Jürgen   +2 more
core  

The geometry of G × E: How scaling and endogenous treatment effects shape interaction direction. [PDF]

PLoS Genet
Sadowski M, Dahl AW, Zaitlen N, Border R.   +3 more
europepmc   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Intrusion detection method based on data augmentation and multi-explanation method fusion

Tongxin xuebao
To address the issues of inconsistent explanations from existing interpretability methods and low decision cre-dibility in intrusion detection systems, a multi-explanatory method fusion technique was proposed.
XIONG Xuanrui, GUO Xingyou, NING Zhaolong, ZHANG Yushu, ZHOU Li   +4 more
doaj  

Adopting digital technologies and 3D printing in prosthetics and orthotics: Lessons from a decade of clinical practice. [PDF]

Can Prosthet Orthot J
Blocka D.
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Ambiguity and uncertainty in Ellsberg and Shackle [PDF]

This paper argues that Ellsberg’s and Shackle’s frameworks for discussing the limits of the (subjective) probabilistic approach to decision theory are not as different as they may appear.
Carlo Zappia, Marcello Basili
core