Results 131 to 140 of about 128,882 (238)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Navy Additive Manufacturing (AM) Afloat Capability Laydown

, 2020
NPS-20-N290B N45 - Environmental Protection, Safety and Occupational Health ...
Sadagic, Amela, Van Bossuyt, Douglas
openaire   +2 more sources

An Encoder-Decoder Based Approach for Anomaly Detection with Application in Additive Manufacturing [PDF]

, 1879
We present a novel unsupervised deep learning approach that utilizes an encoder-decoder architecture for detecting anomalies in sequential sensor data collected during industrial manufacturing.
Jin, Baihong, Tan, Yingshui, Nettekoven, Alexander, Chen, Yuxin, Topcu, Ufuk, Yue, Yisong, Sangiovanni Vincentelli, Alberto   +6 more
core  

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

3D printing: A qualitative assessment of applications, recent trends and the technology's future potential

, 2015
Additive manufacturing (AM) or 3D printing is currently one of the most discussed emerging technologies coming to market with a potentially disruptive power.
Bechthold, Laura, Fischer, Veronika, Hainzlmaier, Andre, Hugenroth, Daniel, Ivanova, Ljudmila, Kroth, Kristina, Römer, Benedikt, Sikorska, Edyta, Sitzmann, Vincent   +8 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Energy Efficiency and Sustainability of Additive Manufacturing as a Mass-Personalized Production Mode in Industry 5.0/6.0

Energies
This review article examines the role of additive manufacturing (AM) in increasing energy efficiency and sustainability within the evolving framework of Industry 5.0 and 6.0.
Izabela Rojek, Dariusz Mikołajewski, Jakub Kopowski, Tomasz Bednarek, Krzysztof Tyburek   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Microwave Characterization of Metal Powder in Additive Manufacturing (AM)

IEEE Open Journal of Instrumentation and Measurement
Common additive manufacturing (AM) methods use metal powder feedstock. The properties of the metal powder, such as particle size distribution (PSD), morphology, and presence of surface oxides or other contaminants, significantly impact the quality of the built part.
Joseph Filbert, Aaron Barvincak, Mohammad Tayeb Al Qaseer, Reza Zoughi   +3 more
openaire   +2 more sources