Results 41 to 50 of about 17,462 (263)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Framing Artificial Intelligence (AI) Additive Manufacturing (AM)
Procedia Computer Science, 2021 Abstract Nowadays AM is a rapidly growing and emerging discipline in manufacturing, as well as AI is in informational applications. Both are related to logistical and self-referential/-copying concepts which make them scalable. What is in AM osmotic mass production spreading is in AI-related Cyber-Physical Systems (CPS) the osmotic computational ...
Bernhard Heiden +3 more
openaire +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Additive (nano)manufacturing perspectives: the use of nanofillers and tailored materials
Manufacturing Review, 2017 Additive manufacturing (AM) is identified to cost-effectively lower manufacturing inputs and outputs in small batch production, widely employed in customized and high-value manufacturing chains, such as aerospace and medical component manufacturing ...
Koumoulos Elias P. +2 more
doaj +1 more source
Metals, 2019 This article shows a method for inspection scheduling of structures made by additive manufacturing, derived from reliability function evaluations and overhaul inspection findings. The routine was an adaption of an existing method developed by the authors
Armando Coro +3 more
doaj +1 more source
Applicability analysis of additive manufacturing methods on construction projects
Građevinar, 2020 Additive manufacturing (AM) technologies, also known as 3D-printing systems, have been rapidly gaining popularity in the construction industry. Recent developments in additive manufacturing technologies indicate that large-scale 3D printing systems have ...
Fahriye Hilal Halicioglu, Seckin Koralay
doaj +1 more source
Development of a Low-Cost Wire Arc Additive Manufacturing System
Journal of Manufacturing and Materials Processing, 2021 Due to their unique advantages over traditional manufacturing processes, metal additive manufacturing (AM) technologies have received a great deal of attention over the last few years. Using current powder-bed fusion AM technologies, metal components are
Miguel Navarro +3 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Heterogeneous Material Additive Manufacturing for Hot-Stamping Die
Metals, 2020 Additive manufacturing (AM) has recently been receiving global attention. As an innovative alternative to existing manufacturing technologies, AM can produce three-dimensional objects from various materials.
Myoung-Pyo Hong +6 more
doaj +1 more source