Results 181 to 190 of about 1,103 (233)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

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Additive adjoint preservers between matrix spaces

Linear and Multilinear Algebra, 2006
Let F be a field and let n, m be positive integers with m ≥ 2 and n ≥ 3. Denote by M n (F) (respectively, S n (F) and T n (F)) the linear space of all n × n full (respectively, symmetric and triangular) matrices over F. For any matrix A ∊ M n (F), the symbol A ad denotes the adjoint matrix of A.
Xiao-Min Tang, Xian Zhang
openaire   +3 more sources

Additives to preservation solutions

Progrès en Urologie, 2014
As the impact of ischemia reperfusion injury on graft outcome is now well defined, efforts are made towards decreasing these lesions, typically through the improvement of preservation techniques. The use of pharmacological supplements which could be compatible with any preservation solution used by the transplant center and target specific pathways of ...
T, Saint Yves, P-O, Delpech, S, Giraud, R, Thuillier, T, Hauet   +4 more
openaire   +2 more sources

Additive Solutions for Better Blood Preservation

CRC Critical Reviews in Clinical Laboratory Sciences, 1987
For several decades the standard blood preservative solution consisted of citrate, dextrose, and, later, phosphate (ACD and CPD). In 1978 a new solution containing adenine (CPDA-1) was introduced to permit extension of red cell shelf life from 21 to 35 days.
Gerald L. Moore, John G Batsakis
openaire   +2 more sources

Indefinite orthogonality preserving additive maps

Archiv der Mathematik, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Cui, Jianlian, Hou, Jinchuan, Park, Chun-Gil   +2 more
openaire   +1 more source