Results 31 to 40 of about 1,234 (221)
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Ascent, descent and additive preserving problems [PDF]
Given an integer $n\geq 1$ , we provide a complete description of all additive surjective maps, on the algebra of all bounded linear operators acting on a complex separable infinite-dimensional Hilbert space, preserving in both directions the set of all bounded linear operators with ascent (resp. descent) non-greater than $n$ . In the context
Mourad Oudghiri, Khalid Souilah
openaire +1 more source
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Maps preserving the spectrum of certain products of operators [PDF]
Let H be a complex Hilbert space, B(H) and S(H) be the spaces of all bounded operators and all self-adjoint operators on H, respectively. We give the concrete forms of the maps on B(H) and also S(H) which preserve the spectrum of certain products of ...
Hosseinzadeh, Roja, Taghavi, Ali
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Maps preserving peripheral spectrum of generalized products of operators [PDF]
Let $\mathcal{A}_1$ and $\mathcal{A}_2$ be standard operator algebras on complex Banach spaces $X_1$ and $X_2$, respectively. For $k\geq2$, let $(i_1,...,i_m)$ be a sequence with terms chosen from $\{1,\ldots,k\}$, and assume that at least one of the ...
Hou, Jinchuan, Zhang, Wen
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source

