Results 71 to 80 of about 4,194,164 (301)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Addressing Unequal Treatment: Disparities in Health Care [PDF]
, 2004 Looks at the role of federal government in the health care of minority Americans, and current strategies and legislative efforts to address issues raised by racial and ethnic disparities in health ...
Gillian K. SteelFisher
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Interfaces of Contemporary Poetry: Turn-taking and Multiple Addressing
Слово.ру: балтийский акцентThe characteristic feature of contemporary poetry is an increased attention to the pragmatics of the message. The Internet influences the activation of the communication function, and metalinguistic reflection in poetry manifests itself through the ...
Zakharkiv E.V.
doaj +1 more source
AJN, American Journal of Nursing, 1911 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Metapragmatic Awareness in Melbourne Greek: Addressee-Oriented Indicators and the T/V Distinction
LanguagesThe role of metapragmatics in maintaining interactional coherence and achieving intersubjectivity has been variously underscored in the last three decades.
Theodossia-Soula Pavlidou
doaj +1 more source
Studia Linguistica Hungarica, 2022 The paper takes as its starting point the premise that address can be understood as a speech act. It asks wherein lies the performative outcome and power of address and self-address, in particular with regard to the effect of the address on the addressee.
openaire +2 more sources