Results 71 to 80 of about 1,170,430 (263)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Interfaces of Contemporary Poetry: Turn-taking and Multiple Addressing

Слово.ру: балтийский акцент
The characteristic feature of contemporary poetry is an increased attention to the prag­matics of the message. The Internet influences the activation of the communication function, and metalinguistic reflection in poetry manifests itself through the ...
Zakharkiv E.V.
doaj   +1 more source

Aspekte van mikrostrukturele ver-skeidenheid en inkonsekwentheid in woordeboeke

Lexikos, 2011
<p>gewoonlik deur diegene wie se dialek nie goed verteenwoordig is nie. Die artikel bevat die skrywer se ervaring in die African Languages Lexical (ALLEX) Project, tans die African Languages Research Institute (ALRI).
Rufus H. Gouws
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Metapragmatic Awareness in Melbourne Greek: Addressee-Oriented Indicators and the T/V Distinction

Languages
The role of metapragmatics in maintaining interactional coherence and achieving intersubjectivity has been variously underscored in the last three decades.
Theodossia-Soula Pavlidou
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Domain Name: Digital Asset, Identifier, or Some Other Kind of Object?

Цифровое право
This article is dedicated to a comprehensive analysis of the legal nature of a domain name as a special object functioning in the digital environment and proactively involved in civil commerce.
I. E. Titov, E. V. Alymova
doaj   +1 more source

2315

Journal of Clinical and Translational Science, 2017
OBJECTIVES/SPECIFIC AIMS: Addressing Disparities in Asian Populations through Translation research (ADAPT) is a community-research partnership funded by the Tufts Clinical Translational Sciences Institute (CTSI).
Amy LeClair, Carolyn Rubin, Addressing Disparities in Asian Populations through Translational Research   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Dynamics of the food-water-ecosystem nexus and their driving forces under changing environments in the agro-pastoral ecotone of northern China

Environmental and Sustainability Indicators
In recent decades, escalating climate change, continuous population growth, rapid urbanization, and extensive agricultural development have placed increasing pressure on global ecosystems.
Riping Gao, Zhihua Pan, Pengshuai Bi, Zhanrui Huang, Fangxiao Zhang, Jinyu Men, Na Huang, Rongdao Yang, Xiaoyue Liu, Yupeng Jing, Peiyi Zhao   +10 more
doaj   +1 more source