A Comprehensive Database for DNA Adductomics [PDF]
Frontiers in Chemistry, 2022 The exposure of human DNA to genotoxic compounds induces the formation of covalent DNA adducts, which may contribute to the initiation of carcinogenesis.
Giorgia La Barbera +4 more
doaj +7 more sources
DNA Adductomics: A Narrative Review of Its Development, Applications, and Future [PDF]
BiomoleculesDNA adductomics is the global study of all DNA adducts and was first proposed in 2006 by the Matsuda group. Its development has been greatly credited to the advances in mass spectrometric techniques, particularly tandem and multiple-stage mass ...
Mengqiu Cao, Xinyu Zhang
doaj +6 more sources
Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia [PDF]
AntioxidantsFetal and neonatal exposures to perinatal oxidative stress (OS) are key mediators of bronchopulmonary dysplasia (BPD). To characterize these exposures, adductomics is an exposure science approach that captures electrophilic addition products (adducts) in
Erika T. Lin +7 more
doaj +8 more sources
Quo vadis blood protein adductomics? [PDF]
Archives of Toxicology, 2021 Chemicals are measured regularly in air, food, the environment, and the workplace. Biomonitoring of chemicals in biological fluids is a tool to determine the individual exposure.
Gabriele Sabbioni, Billy W. Day
core +8 more sources
Protein Adductomics: Analytical Developments and Applications in Human Biomonitoring [PDF]
Toxics, 2019 Proteins contain many sites that are subject to modification by electrophiles. Detection and characterisation of these modifications can give insights into environmental agents and endogenous processes that may be contributing factors to chronic human ...
George W. Preston, David H. Phillips
doaj +6 more sources
Development of an Optimized Two-Step Solid-Phase Extraction Method for Urinary Nucleic Acid Adductomics [PDF]
BiomoleculesThe exposome represents the totality of endogenous and exogenous exposures across the lifespan. These exposures may result in DNA and RNA damage, in the form of adducts, which is a key factor in the etiology of a variety of human diseases, including ...
Alexandra Keidel +9 more
doaj +4 more sources
A Metabolomics-Inspired Strategy for the Identification of Protein Covalent Modifications [PDF]
Frontiers in Chemistry, 2019 Identification of protein covalent modifications (adducts) is a challenging task mainly due to the lack of data processing approaches for adductomics studies.
João Nunes +9 more
doaj +5 more sources
FLEXiGUT: Rationale for exposomics associations with chronic low-grade gut inflammation [PDF]
Environment International, 2022 FLEXiGUT is the first large-scale exposomics study focused on chronic low-grade inflammation. It aims to characterize human life course environmental exposure to assess and validate its impact on gut inflammation and related biological processes and ...
Roger Pero-Gascon +9 more
doaj +3 more sources
Mass spectrometric profiling of DNA adducts in the human stomach associated with damage from environmental factors [PDF]
Genes and Environment, 2021 Background A comprehensive understanding of DNA adducts, one of the most plausible origins of cancer mutations, is still elusive, especially in human tissues in clinical settings.
Ippei Ohnishi +15 more
doaj +2 more sources
Spatial mapping of the DNA adducts in cancer. [PDF]
DNA Repair (Amst), 2023 DNA adducts and strand breaks are induced by various exogenous and endogenous agents. Accumulation of DNA damage is implicated in many disease processes, including cancer, aging, and neurodegeneration.
Krieger KL +9 more
europepmc +3 more sources