Results 161 to 170 of about 901 (172)

Detection and Quantification of Drug-Protein Adducts in Human Liver. [PDF]

J Proteome Res
Zelter A, Riffle M, Shteynberg DD, Zhong G, Riddle EB, Hoopmann MR, Jaschob D, Moritz RL, Davis TN, MacCoss MJ, Isoherranen N.   +10 more
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Describing Biological Vulnerability in Small, Vulnerable Newborns in Urban Burkina Faso (DenBalo): Gut Microbiota, Immune System, and Breastmilk Assembly. [PDF]

Nutrients
Ouédraogo LO, Deng L, Ouattara CA, Compaoré A, Ouédraogo M, Argaw A, Lachat C, Houpt ER, Saidi Q, Haerynck F, Sonnenburg J, Azad MB, Tavernier SJ, Bastos-Moreira Y, Toe LC, Dailey-Chwalibóg T.   +15 more
europepmc   +1 more source

Study on HILIC Separation Conditions for DNA Adductomics

Study on HILIC Separation Conditions for DNA Adductomics
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Extending the HSA-Cys34-Adductomics Pipeline to Modifications at Lys525

Chemical Research in Toxicology, 2021
We previously developed an adductomics pipeline that employed nanoflow liquid chromatography and high-resolution tandem mass spectrometry (nLC-HR-MS/MS) plus informatics to perform an untargeted detection of modifications to Cys34 in the tryptic T3 peptide of human serum albumin (HSA) (21ALVLIAFAQYLQQC34PFEDHVK41).
Hasmik Grigoryan, Partow Imani, Sandrine Dudoit, Stephen M. Rappaport   +3 more
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Abstract 2257: DNA adductome analysis in human colorectal tissues

Cancer Research, 2022
Abstract Due to recent advancement of DNA sequencing technologies, cancer genome analysis has shown that somatic mutations have different trends in various tissues and individuals. Some of trends has been associated with exposure of chemically reactive compounds derived from exogenous or endogenous sources and genetic deficiencies in DNA
Yuji Iwashita, Shunsuke Ohtsuka, Ippei Ohnishi, Yuto Matsushita, Takashi Yamashita, Keisuke Inaba, Atsuko Fukazawa, Hideto Ochiai, Keigo Matsumoto, Nobuhito Kurono, Yoshitaka Matsushima, Hiroki Mori, Shioto Suzuki, Shohachi Suzuki, Fumihiko Tanioka, Haruhiko Sugimura   +15 more
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Development of the Adductome Approach to Detect DNA Damage in Humans

Antioxidants & Redox Signaling, 2006
The development of new strategies designed to detect DNA damage caused by oxidative stress and other means may advance our understanding of the roles of such types of damage in the etiology of cancers, in aging processes, and as biomarkers of exposure.
Robert A, Kanaly, Tomoyuki, Hanaoka, Haruhiko, Sugimura, Hirokazu, Toda, Saburo, Matsui, Tomonari, Matsuda   +5 more
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Protein adductomics: A comprehensive analysis of protein modifications by electrophiles

Free Radical Biology and Medicine, 2019
Human individuals are continually exposed to various exogenous and endogenous reactive electrophiles, which readily react with nucleophilic biomacromolecules, such as protein, and form a variety of covalent adducts. The covalent modifications of protein are thought to be involved in various physiological and pathological processes.
Takahiro, Shibata, Koji, Uchida
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Mass spectrometry-based DNA adductomics

TrAC Trends in Analytical Chemistry, 2022
Yuxiang Cui, Yinsheng Wang
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Abstract 47: DNA adductome: An ultimate exposome of human tissues.

Cancer Epidemiology, Biomarkers & Prevention, 2012
Abstract The formation of DNA adducts and the subsequent generation of mutations in the genome is believed to be a pivotal event in the pathogenesis of cancer, but several obstacles have hampered a concrete demonstration of the molecular species, quantity, and significance of DNA adducts in human tissues.
Haruhiko Sugimura, Hong Tao, Nobuya Kurabe, Masanori Goto, Yoshitaka Matsushima, Hidetaka Yamada, Kazuya Shinmura, Yohei Miyagi, Akira Tsuburaya, Takaki Yoshikawa, Yukari Totsuka, Hitoshi Nakagama, Yaping Wang, Tomonari Matsuda   +13 more
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Development of a genotoxicity/carcinogenicity assessment method by DNA adductome analysis

Mutation Research - Genetic Toxicology and Environmental Mutagenesis
Safety evaluation is essential for the development of chemical substances. Since in vivo safety evaluation tests, such as carcinogenesis tests, require long-term observation using large numbers of experimental animals, it is necessary to develop alternative methods that can predict genotoxicity/carcinogenicity in the short term, taking into account the
Kohei, Watanabe, Masami, Komiya, Asuka, Obikane, Tsubasa, Miyazaki, Kousuke, Ishino, Keita, Ikegami, Hiroki, Hashizume, Yukako, Ishitsuka, Takashi, Fukui, Min, Gi, Shugo, Suzuki, Hideki, Wanibuchi, Yukari, Totsuka   +12 more
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