Overview of Adductomics in Toxicology. [PDF]
Curr Protoc, 2023 AbstractAdductomics is epidemiology at the molecular level. Untargeted adductomics compares levels of chemical adducts on albumin, hemoglobin, and DNA between healthy and exposed individuals. The goal is to determine a cause‐and‐effect relationship between chemical exposure and illness.
Lockridge O.
europepmc +4 more sources
DNA Adductomics by mass tag prelabeling. [PDF]
Rapid Commun Mass Spectrom, 2021 Rationale As a new approach to DNA adductomics, we directly reacted intact, double‐stranded (ds)‐DNA under warm conditions with an alkylating mass tag followed by analysis by liquid chromatography/mass spectrometry. This method is based on the tendency of adducted nucleobases to locally disrupt the DNA structure
Wang P +6 more
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Applications of Adductomics in Chemically Induced Adverse Outcomes and Major Emphasis on DNA Adductomics: A Pathbreaking Tool in Biomedical Research. [PDF]
Int J Mol Sci, 2021 Adductomics novel and emerging discipline in the toxicological research emphasizes on adducts formed by reactive chemical agents with biological molecules in living organisms. Development in analytical methods propelled the application and utility of adductomics in interdisciplinary sciences.
Behl T +15 more
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Editorial: Mass Spectrometry for Adductomic Analysis [PDF]
Frontiers in Chemistry, 2019 Marcus S. Cooke +4 more
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Extension of Diagnostic Fragmentation Filtering for Automated Discovery in DNA Adductomics. [PDF]
Anal Chem, 2021 Development of high-resolution/accurate mass liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS) methodology enables the characterization of covalently modified DNA induced by interaction with genotoxic agents in complex biological samples.
Murray KJ +5 more
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Current and Future Methodology for Quantitation and Site-Specific Mapping the Location of DNA Adducts [PDF]
Toxics, 2022 Formation of DNA adducts is a key event for a genotoxic mode of action, and their presence is often used as a surrogate for mutation and increased cancer risk.
Gunnar Boysen, Intawat Nookaew
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Tissue-specific mutagenesis from endogenous guanine damage is suppressed by Polκ and DNA repair [PDF]
Nature CommunicationsKnowledge of mutational patterns has expanded significantly, but linking these patterns to specific molecular mechanisms or sources of endogenous DNA damage remains challenging.
Yang Jiang +18 more
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nLossFinder—A Graphical User Interface Program for the Nontargeted Detection of DNA Adducts [PDF]
Toxics, 2021 DNA adductomics is a relatively new omics approach aiming to measure known and unknown DNA modifications, called DNA adducts. Liquid chromatography–tandem mass spectrometry (LC-MS/MS) has become the most common method for analyzing DNA adducts.
Pedro F. M. Sousa +4 more
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Shotgun Proteomic-Based Approach with a Q-Exactive Hybrid Quadrupole-Orbitrap High-Resolution Mass Spectrometer for Protein Adductomics on a 3D Human Brain Tumor Neurospheroid Culture Model: The Identification of Adduct Formation in Calmodulin-Dependent Protein Kinase-2 and Annexin-A1 Induced by Pesticide Mixture. [PDF]
J Proteome Res, 2023 Pesticides are increasingly used in combinations in crop protection, resulting in enhanced toxicities for various organisms. Although protein adductomics is challenging, it remains a powerful bioanalytical tool to check environmental exposure and ...
Louati K +15 more
europepmc +3 more sources
HSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism [PDF]
AntioxidantsNearly one fourth of lung cancers occur among never-smokers and are predominately lung adenocarcinomas (LUADs) that are distinct from smoking-related cancers.
Partow Imani +15 more
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