Urinary DNA adductomics – A novel approach for exposomics
Environment International, 2018 The exposome is a concept that encompasses the totality of internal and external environmental exposures, from conception onwards. Evaluation of the exposome, across the lifecourse represents a significant challenge, e.g., methods/technology may simply ...
Marcus S. Cooke +3 more
doaj +3 more sources
New horizons of DNA adductome for exploring environmental causes of cancer [PDF]
Cancer Science, 2020 AbstractChemical carcinogenesis is focused on the formation of DNA adducts, a form of DNA damage caused by covalent binding of a chemical moiety to DNA. The detection of carcinogen‐DNA adducts in human tissues, along with demonstration of mutagenicity/carcinogenicity in experimental systems, and validation of adducts as biomarkers of environmental ...
Yukari Totsuka +2 more
openaire +3 more sources
Two-dimensional nanostructures based '-onics' and '-omics' in personalized medicine [PDF]
Nanophotonics, Volume 11, Issue 22, Page 5019-5039, December 2022., 2022 With the maturing techniques for advanced synthesis and engineering of two-dimensional (2D) materials, its nanocomposites, hybrid nanostructures, alloys, and heterostructures, researchers have been able to create materials with improved as well as novel ...
Chander, Dhanabalan, S. +6 more
core +2 more sources
In vitro DNA/RNA Adductomics to Confirm DNA Damage Caused by Benzo[a]pyrene in the Hep G2 Cell Line [PDF]
Frontiers in Chemistry, 2019 In the development of new chemical substances, genetic toxicity evaluations are a high priority for safety risk management. Evaluation of the possibility of compound carcinogenicity with accuracy and at reasonable cost in the early stages of development ...
Toshihide Takeshita, Robert A. Kanaly
doaj +2 more sources
Protein Adductomics: Methodologies for Untargeted Screening of Adducts to Serum Albumin and Hemoglobin in Human Blood Samples. [PDF]
High Throughput, 2019 The reaction products of electrophiles in vivo can be measured as adducts to the abundant proteins, hemoglobin (Hb), and human serum albumin (HSA), in human blood samples.
Carlsson H, Rappaport SM, Törnqvist M.
europepmc +4 more sources
The Cooked Meat Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Hair Dosimeter, DNA Adductomics Discovery, and Associations with Prostate Cancer Pathology Biomarkers. [PDF]
Chem Res Toxicol, 2022 Guo J +8 more
europepmc +3 more sources
Nanoscale battery cathode materials induce DNA damage in bacteria. [PDF]
Chem Sci, 2020 The increasing use of nanoscale lithium nickel manganese cobalt oxide (LixNiyMnzCo1−y−zO2, NMC) as a cathode material in lithium-ion batteries poses risk to the environment.
Qiu TA +11 more
europepmc +3 more sources
Identifying Novel DNA Adducts in Amphipods and Developing Sample Preparation for Adductomics Using Dispersive Solid-Phase Extraction. [PDF]
Environ Sci TechnolKhan Z +6 more
europepmc +3 more sources
The need for a cancer exposome atlas: a scoping review. [PDF]
JNCI Cancer SpectrBackground: Despite advances in understanding genetic susceptibility to cancer, much of cancer heritability remains unidentified. At the same time, the makeup of industrial chemicals in our environment only grows more complex.
Young AS +11 more
europepmc +3 more sources
Nucleic acid adductomics - The next generation of adductomics towards assessing environmental health risks. [PDF]
Sci Total Environ, 2023 This Discussion article aims to explore the potential for a new generation of assay to emerge from cellular and urinary DNA adductomics which brings together DNA-RNA- and, to some extent, protein adductomics, to better understand the role of the exposome in environmental health.
Cooke MS +4 more
europepmc +3 more sources