Results 31 to 40 of about 901 (172)
A cry for kelp: Evidence for polyphenolic inhibition of Oxford Nanopore sequencing of brown algae [PDF]
Journal of Phycology, Volume 60, Issue 6, Page 1601-1610, December 2024.\ua9 2024 The Author(s). Journal of Phycology published by Wiley Periodicals LLC on behalf of Phycological Society of America.Genomic resources have yielded unprecedented insights into ecological and evolutionary processes, not to mention their ...
Arranz V +12 more
core +2 more sources
Nucleic Acid Adductomics – the Next Generation of Adductomics for Assessing Environmental Health Risk [PDF]
, 2022 AbstractThe exposome describes the totality of internal and external environmental exposures, across the life course. Components of the exposome have been linked to an increased risk of various, major diseases. To identify the precise nature, and size, of risk, in this complex mixture of exposures, powerful tools are needed to link exposure, cellular ...
Marcus S. Cooke +4 more
openalex +2 more sources
Commentary on: Is preheat necessary for the measurement of 8-oxo-7,8-dihydroguanosine and 8-oxo-7,8-dihydro-2'-deoxyguanosine in urine samples. [PDF]
J Clin Lab Anal, 2023 Journal of Clinical Laboratory Analysis, Volume 37, Issue 6, March 2023.
Hu CW, Cooke MS, Wang YJ, Chao MR.
europepmc +2 more sources
Mass Spectrometry-Based Strategies for Assessing Human Exposure Using Hemoglobin Adductomics. [PDF]
Chem Res Toxicol, 2023 Hemoglobin (Hb) adducts are widely used in human biomonitoring due to the high abundance of hemoglobin in human blood, its reactivity toward electrophiles, and adducted protein stability for up to 120 days. In the present paper, we compared three methods of analysis of hemoglobin adducts: mass spectrometry of derivatized N-terminal Val adducts, mass ...
Rajczewski AT +8 more
europepmc +3 more sources
Adductomic signatures of benzene exposure provide insights into cancer induction [PDF]
Carcinogenesis, 2018 Although benzene has long been recognized as a cause of human leukemia, the mechanism by which this simple molecule causes cancer has been problematic. A complicating factor is benzene metabolism, which produces many reactive intermediates, some specific to benzene and others derived from redox processes. Using archived serum from 20 nonsmoking Chinese
Hasmik Grigoryan +10 more
openalex +5 more sources
An Adductomic Approach to Identify Electrophiles In Vivo [PDF]
Basic & Clinical Pharmacology & Toxicology, 2016 AbstractHuman beings are exposed to many reactive electrophiles, both formed endogenously and from exogenous exposures. Such compounds could react with cellular biomolecules and form stable reaction products, adducts, at nucleophilic sites in proteins and DNA, constituting a risk for toxic effects.
Henrik Carlsson, Margareta Törnqvist
openalex +3 more sources
Identification of New Markers of Alcohol-Derived DNA Damage in Humans
Biomolecules, 2021 Alcohol consumption is a risk factor for the development of several cancers, including those of the head and neck and the esophagus. The underlying mechanisms of alcohol-induced carcinogenesis remain unclear; however, at these sites, alcohol-derived ...
Valeria Guidolin +6 more
doaj +1 more source
Mass Spectral Library for DNA Adductomics. [PDF]
Chem Res ToxicolEndogenous electrophiles, ionizing and non-ionizing radiation, and hazardous chemicals present in the environment and diet can damage DNA by forming covalent adducts. DNA adducts can form in critical cancer driver genes and, if not repaired, may induce mutations during cell division, potentially leading to the onset of cancer.
Walmsley SJ +6 more
europepmc +3 more sources
Adductomics: Characterizing exposures to reactive electrophiles [PDF]
Toxicology Letters, 2012 To understand environmental causes of disease, unbiased methods are needed to characterize the human exposome, which represents all toxicants to which people are exposed from both exogenous and endogenous sources. Because they directly modify DNA and important proteins, reactive electrophiles are probably the most important constituents of the exposome.
Stephen M, Rappaport +4 more
openaire +2 more sources
A nested case-control study of untargeted albumin adductomics and acute myeloid leukemia. [PDF]
Int J Cancer, 2023 AbstractEnvironmental exposures often produce reactive electrophiles in vivo, leading to oxidative stress, which plays a major role in carcinogenesis. These electrophiles frequently form adducts with human albumin, which can be measured to assess in vivo oxidative stress.
Rahman ML +10 more
europepmc +3 more sources