Results 41 to 50 of about 901 (172)

Human Serum Albumin Cys34 Adducts in Newborn Dried Blood Spots: Associations With Air Pollution Exposure During Pregnancy

Frontiers in Public Health, 2021
Background: Increasing evidence suggests that exposure to air pollution during pregnancy is associated with adverse pregnancy outcomes. However, biomarkers associated with air pollution exposure are widely lacking and often transient.
William E. Funk, Nathan Montgomery, Yeunook Bae, Jiexi Chen, Ting Chow, Mayra P. Martinez, Fred Lurmann, Sandrah P. Eckel, Rob McConnell, Anny H. Xiang   +9 more
doaj   +1 more source

Risk assessment of N‐nitrosamines in food

EFSA Journal, Volume 21, Issue 3, March 2023., 2023
Abstract EFSA was asked for a scientific opinion on the risks to public health related to the presence of N‐nitrosamines (N‐NAs) in food. The risk assessment was confined to those 10 carcinogenic N‐NAs occurring in food (TCNAs), i.e. NDMA, NMEA, NDEA, NDPA, NDBA, NMA, NSAR, NMOR, NPIP and NPYR.
EFSA Panel on Contaminants in the Food Chain (EFSA CONTAM Panel), Dieter Schrenk, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Jean‐Charles Leblanc, Carlo Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Tanja Schwerdtle, Christiane Vleminckx, Heather Wallace, Benigni Romualdo, Cristina Fortes, Stephen Hecht, Marco Iammarino, Olaf Mosbach‐Schulz, Francesca Riolo, Anna Christodoulidou, Bettina Grasl‐Kraupp   +24 more
wiley   +1 more source

Multi-adductomics: Advancing mass spectrometry techniques for comprehensive exposome characterization. [PDF]

Trends Analyt Chem
Adductomics, an emerging field within the 'omics sciences, focuses on the formation and prevalence of DNA, RNA, and protein adducts induced by endogenous and exogenous agents in biological systems. These modifications often result from exposure to environmental pollutants, dietary components, and xenobiotics, impacting cellular functions and ...
Chao MR, Chang YJ, Cooke MS, Hu CW.
europepmc   +3 more sources

Lipid peroxidation derived reactive carbonyl species in free and conjugated forms as an index of lipid peroxidation: limits and perspectives [PDF]

, 2021
Reactive carbonyl species (RCS) formed by lipidperoxidation as free forms or as enzymatic and non-enzymatic conjugates are widely used as an index of oxidative stress.
Aldini G., Altomare A., Banfi C., Baron G., Carini M., Gianazza E.   +5 more
core   +1 more source

The Future of DNA Adductomic Analysis [PDF]

International Journal of Molecular Sciences, 2017
Covalent modification of DNA, resulting in the formation of DNA adducts, plays a central role in chemical carcinogenesis. Investigating these modifications is of fundamental importance in assessing the mutagenicity potential of specific exposures and understanding their mechanisms of action. Methods for assessing the covalent modification of DNA, which
Peter Villalta, Silvia Balbo
openaire   +2 more sources

In Silico Tandem Mass Spectrometer: an Analytical and Fundamental Tool

Chemistry–Methods, Volume 1, Issue 2, Page 123-130, February 2021., 2021
According to plan: Chemical dynamics simulations can be used to predict and rationalize tandem mass spectra relevant to biochemical studies. The latest advances have been discussed and possible applications to build an in silico database have been proposed.
Andrea Carrà, Riccardo Spezia
wiley   +1 more source

Special Issue "Adductomics: Elucidating the Environmental Causes of Disease". [PDF]

High Throughput, 2019
Adductomics studies represent effective tools for providing additional insights into how exposure to reactive metabolites can underlie disease mechanisms. This special issue is focused not only on summarizing the analytical methodologies used for DNA, protein, and mercapturic acid adductomics tools but also on highlighting the opportunities and ...
Pereira SA, Antunes AMM.
europepmc   +4 more sources

Adductome-based identification of biomarkers for lipid peroxidation [PDF]

Journal of Biological Chemistry, 2017
Lipid peroxidation is an endogenous source of aldehydes that gives rise to covalent modification of proteins in various pathophysiological states. In this study, a strategy for the comprehensive detection and comparison of adducts was applied to find a biomarker for lipid peroxidation-modified proteins in vivo This adductome approach utilized liquid ...
Takahiro, Shibata, Kazuma, Shimizu, Keita, Hirano, Fumie, Nakashima, Ryosuke, Kikuchi, Tadashi, Matsushita, Koji, Uchida   +6 more
openaire   +2 more sources

Mapping the Human Exposome to Uncover the Causes of Breast Cancer. [PDF]

, 2019
Breast cancer is an important cause of morbidity and mortality for women, yet a significant proportion of variation in individual risk is unexplained. It is reasonable to infer that unexplained breast cancer risks are caused by a myriad of exposures and ...
Bessonneau, Vincent, Rudel, Ruthann A
core   +2 more sources

DNA Adductomics

Chemical Research in Toxicology, 2014
Systems toxicology is a broad-based approach to describe many of the toxicological features that occur within a living system under stress or subjected to exogenous or endogenous exposures. The ultimate goal is to capture an overview of all exposures and the ensuing biological responses of the body.
Balbo, Silvia, Turesky, Robert J., Villalta, Peter W.   +2 more
openaire   +2 more sources