Results 51 to 60 of about 901 (172)
Emerging Technologies in Mass Spectrometry-Based DNA Adductomics [PDF]
High-Throughput, 2019 The measurement of DNA adducts, the covalent modifications of DNA upon the exposure to the environmental and dietary genotoxicants and endogenously produced electrophiles, provides molecular evidence for DNA damage. With the recent improvements in the sensitivity and scanning speed of mass spectrometry (MS) instrumentation, particularly high-resolution
Jingshu Guo, Robert J. Turesky
openaire +2 more sources
Biomarkers of nucleic acid oxidation – A summary state-of-the-art
Redox Biology, 2021 Oxidatively generated damage to DNA has been implicated in the pathogenesis of a wide variety of diseases. Increasingly, interest is also focusing upon the effects of damage to the other nucleic acids, RNA and the (2′-deoxy-)ribonucleotide pools, and ...
Mu-Rong Chao +6 more
doaj +1 more source
Development of DNA Adductome Mass Spectral Database
Chemical Research in Toxicology, 2020 Mass spectrometry-based DNA adductomics is an emerging approach for the human biomonitoring of hazardous chemicals. A mass spectral database of DNA adducts will be created for the scientific community to investigate the associations between chemical exposures, DNA damage, and disease risk.
Jingshu Guo +6 more
openaire +3 more sources
Contemporary Clinical Trials Communications, 2021 Background: Assessing biomarker profiles in various body fluids is of large value to discern between the sole use of nicotine products. In particular, the assessment of the product compliance is required for long-term clinical studies.
Filip Sibul +6 more
doaj +1 more source
Environment International, 2020 The exposome concept refers to the totality of exposures from a variety of external and internal sources including chemical agents, biological agents, or radiation, from conception onward, over a complete lifetime.
Paolo Vineis +5 more
doaj +1 more source
BMC Veterinary Research, 2021 Background Both human and veterinary cancer chemotherapy are undergoing a paradigm shift from a “one size fits all” approach to more personalized, patient-oriented treatment strategies.
Kristine Walters +9 more
doaj +1 more source
Utilizing a biology-driven approach to map the exposome in health and disease:An essential investment to drive the next generation of environmental discovery [PDF]
, 2021 BACKGROUND: Recent developments in technologies have offered opportunities to measure the exposome with unprecedented accuracy and scale. However, because most investigations have targeted only a few exposures at a time, it is hypothesized that the ...
Chung, M.K. +9 more
core +2 more sources
Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light. [PDF]
, 2018 Water treatment systems frequently use strong oxidants or UV light to degrade chemicals that pose human health risks. Unfortunately, these treatments can result in the unintended transformation of organic contaminants into toxic products.
Ford, Breanna +3 more
core +1 more source
Quantitative analysis of malondialdehyde-guanine adducts in genomic DNA samples by liquid chromatography tandem mass spectrometry. [PDF]
, 2017 RATIONALE: The lipid peroxidation product malondialdehyde forms M1 dG adducts with guanine bases in genomic DNA. The analysis of these adducts is important as a biomarker of lipid peroxidation, oxidative stress and inflammation which may be linked to ...
Dempster, NM +3 more
core +2 more sources
International Journal of Cancer, Volume 146, Issue 12, Page 3294-3303, 15 June 2020., 2020 Although smoking and oxidative stress are known contributors to lung carcinogenesis, their mechanisms of action remain poorly understood. To shed light into these mechanisms, we applied a novel approach using Cys34‐adductomics in a lung cancer nested case–control study (n = 212).
Sonia Dagnino +14 more
wiley +1 more source