Results 61 to 70 of about 901 (172)
Frontiers in Chemistry, 2019 The catechol quinone (CQ) motif is present in many biologically relevant molecules throughout endogenous metabolic products, foods, drugs, and environmental pollutants. The CQ derivatives may undergo Michael addition, and has been shown to yield covalent
Shu-Hui Chen, Chun-Wei Li
doaj +1 more source
Genes and Environment, 2021 Background DNA adducts, covalent modifications to DNA due to exposure to specific carcinogens, cause the mispairing of DNA bases, which ultimately results in DNA mutations.
Yuto Matsushita +6 more
doaj +1 more source
Normalized Retention Time for Targeted Analysis of the DNA Adductome [PDF]
Analytical Chemistry, 2018 A wide spectrum of DNA lesions can be generated from byproducts of endogenous metabolism and/or from environmental exposure. A DNA adductomic approach for the robust quantification of DNA adducts in cellular and tissue DNA may facilitate the use of DNA adducts for biomonitoring studies and enable comprehensive assessment about DNA repair.
Yuxiang Cui +4 more
openaire +4 more sources
Redox lipidomics and adductomics - advanced analytical strategies to study oxidized lipids and lipid-protein adducts [PDF]
, 2019 No abstract available ...
Cruciani, Gabriele +4 more
core +1 more source
Targeted High Resolution LC/MS3 Adductomics Method for the Characterization of Endogenous DNA Damage
Frontiers in Chemistry, 2019 DNA can be damaged through covalent modifications of the nucleobases by endogenous processes. These modifications, commonly referred to as DNA adducts, can persist and may lead to mutations, and ultimately to the initiation of cancer.
Andrea Carrà +6 more
doaj +1 more source
Cys34 Adductomes Differ between Patients with Chronic Lung or Heart Disease and Healthy Controls in Central London [PDF]
, 2018 Oxidative stress generates reactive species that modify proteins, deplete antioxidant defenses, and contribute to chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD).
Barratt, Benjamin +11 more
core +3 more sources
Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective [PDF]
, 2021 The concept of the exposome was introduced over 15 years ago to reflect the important role that the environment exerts on health and disease. While originally viewed as a call-to-arms to develop more comprehensive exposure assessment methods applicable ...
Carlsten, Christopher +17 more
core +2 more sources
The “adductome”: a limited repertoire of adducted proteins in human cells [PDF]
DNA Repair, 2019 ABSTRACTProteins form adducts with nucleic acids in a variety of contexts, and these adducts may be cytotoxic if not repaired. Here we apply a proteomic approach to identification of proteins adducted to DNA or RNA in normally proliferating cells. This approach combines RADAR fractionation of proteins covalently bound to nucleic acids with quantitative
Kiianitsa, Kostantin, Maizels, Nancy
openaire +3 more sources