Results 71 to 80 of about 901 (172)
Development of an untargeted DNA adductomics method by ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry [PDF]
, 2022 Giorgia La Barbera, Lars Ove Dragsted
openalex +2 more sources
Metabolomics and adductomics of newborn bloodspots to retrospectively assess the early-life exposome. [PDF]
Curr Opin Pediatr, 2020 Purpose of review Exposomics studies can measure health-relevant chemical exposures during a lifetime and estimate the ‘internal’ environment. However, sampling limitations make these features difficult to capture directly during the critical neonatal time period. Recent findings We
Petrick LM, Uppal K, Funk WE.
europepmc +4 more sources
DNA adduct profiling of in vitro colonic meat digests to map red vs. white meat genotoxicity
, 2018 The consumption of red meat has been linked to an increased colorectal cancer (CRC) risk. One of the major hypotheses states that heme iron (present in red meat) stimulates the formation of genotoxic N-nitroso compounds (NOCs) and lipid peroxidation ...
De Paepe, Ellen +3 more
core +1 more source
Mass Spectrometric Mapping of the DNA Adductome as a Means to Study Genotoxin Exposure, Metabolism, and Effect. [PDF]
, 2016 Covalent binding of endo- or exogenous chemicals to DNA results in the formation of DNA adducts which are reflective of exposure of the human body to DNA-damaging molecules and their metabolic pathways.
Inskeep P. B. +7 more
core +2 more sources
Drug‐Induced Liver Injury Associated With Emerging Cancer Therapies
Liver International, Volume 45, Issue 2, February 2025.ABSTRACT Targeted therapies and immunotherapies have shown great promise as best‐in‐class treatments for several cancers with respect to efficacy and safety. While liver test abnormalities are rather common in patients treated with kinase inhibitors or immunotherapy, events of severe hepatotoxicity in these patients are rare in comparison with those ...
Piotr Chodup +3 more
wiley +1 more source
Advancing human health risk assessment
EFSA Journal, Volume 17, Issue S1, July 2019., 2019 Abstract The current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current approach is considered too resource intensive, is not always reliable, can raise issues of reproducibility, is mostly animal based and does not necessarily provide an understanding of the ...
Anna Lanzoni +26 more
wiley +1 more source
EXPOsOMICS: final policy workshop and stakeholder consultation
BMC Public Health, 2018 The final meeting of the EXPOsOMICS project “Final Policy Workshop and Stakeholder Consultation” took place 28–29 March 2017 to present the main results of the project and discuss their implications both for future research and for regulatory and policy ...
Michelle C. Turner +23 more
doaj +1 more source
EFSA Journal, Volume 15, Issue 10, October 2017., 2017 Abstract In 2013, EFSA published a comprehensive systematic review of epidemiological studies published from 2006 to 2012 investigating the association between pesticide exposure and many health outcomes. Despite the considerable amount of epidemiological information available, the quality of much of this evidence was rather low and many limitations ...
EFSA Panel on Plant Protection Products and their Residues (PPR) +29 more
wiley +1 more source
Assessment of chemically induced genotoxicity and cancer risk by means of DNA adductomics [PDF]
, 2017 C
Hemeryck, Lieselot, Vanhaecke, Lynn
core +1 more source