Results 81 to 90 of about 901 (172)

Methods and Challenges for Computational Data Analysis for DNA Adductomics

Chemical Research in Toxicology, 2019
Frequent exposure to chemicals in the environment, diet, and endogenous electrophiles leads to chemical modification of DNA and the formation of DNA adducts. Some DNA adducts can induce mutations during cell division and, when occurring in critical regions of the genome, can lead to the onset of disease, including cancer.
Scott J. Walmsley, Jingshu Guo, Jinhua Wang, Peter W. Villalta, Robert J. Turesky   +4 more
openaire   +3 more sources

New Exposure Biomarkers as Tools for Breast Cancer Epidemiology, Biomonitoring, and Prevention: A Systematic Approach Based on Animal Evidence [PDF]

, 2014
Background: Exposure to chemicals that cause rodent mammary gland tumors is common, but few studies have evaluated potential breast cancer risks of these chemicals in humans.
Cardiff RD, Conway K, Czene K, D’Hollander W, IARC (International Agency for Research on Cancer)., IARC (International Agency for Research on Cancer)., IARC (International Agency for Research on Cancer)., Izzotti A, Janet M. Ackerman, Julia Green Brody, Kathleen R. Attfield, Rothman N, Russo J, Ruthann A. Rudel   +13 more
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Paraoxonase-1 and Early-Life Environmental Exposures

Annals of Global Health, 2016
Acute and chronic exposures to widely used organophosphorus (OP) insecticides are common. Children's detoxification mechanisms are not well developed until several years after birth.
Judit Marsillach, Lucio G. Costa, Clement E. Furlong   +2 more
doaj   +1 more source

Exploration of LC-MS approaches for DNA adductome mapping and modeling [PDF]

, 2020
Balbo, Silvia, Dator, Romel P., De Graeve, Marilyn, Guidolin, Valeria, Hemeryck, Lieselot, Van de Walle, Emma, Vanhaecke, Lynn, Villalta, Peter W.   +7 more
core   +2 more sources

Chemical and Biological Characterization of Particulate Matter (PM 2.5) and Volatile Organic Compounds Collected at Different Sites in the Los Angeles Basin [PDF]

, 2020
Background: Most studies on air pollution (AP) exposure have focused on adverse health effects of particulate matter (PM). Less well-studied are the actions of volatile organic compounds (VOCs) not retained in PM collections.
Cho, Arthur K, Di Stefano, Emma, Eiguren-Fernandez, Arantza, Froines, John R, Melega, William P, Nani Guarieiro, Aline Lefol, Salinas, Erika M, Schmitz, Debra A, Shinkai, Yasuhiro   +8 more
core   +2 more sources

The Saliva Exposome for Monitoring of Individuals’ Health Trajectories [PDF]

, 2017
Bessonneau, V., Pawliszyn, J., & Rappaport, S. M. (2017). The Saliva Exposome for Monitoring of Individuals’ Health Trajectories. Environmental Health Perspectives, 125(7).
Alvi SN, de Almeida Pdel V, Gann PH, Janusz Pawliszyn, Juniarto AZ, Sakaguchi K, Stephen M. Rappaport, Vincent Bessonneau   +7 more
core   +1 more source

Cys34 Adductomics Links Colorectal Cancer with the Gut Microbiota and Redox Biology [PDF]

Cancer Research, 2019
Abstract Chronic inflammation is an established risk factor for colorectal cancer. To study reactive products of gut inflammation and redox signaling on colorectal cancer development, we used untargeted adductomics to detect adduct features in prediagnostic serum from the EPIC Italy cohort. We
Hasmik Grigoryan, Courtney Schiffman, Marc J. Gunter, Alessio Naccarati, Silvia Polidoro, Sonia Dagnino, Sandrine Dudoit, Paolo Vineis, Stephen M. Rappaport   +8 more
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The plasma proteome, adductome and idiosyncratic toxicity in toxicoproteomics research [PDF]

Briefings in Functional Genomics and Proteomics, 2008
Toxicoproteomics uses the discovery potential of proteomics in toxicology research by applying global protein measurement technologies to biofluids and tissues after host exposure to injurious agents. Toxicoproteomic studies thus far have focused on protein profiling of major organs and biofluids such as liver and blood in preclinical species exposed ...
openaire   +2 more sources

Mapping assays to the key characteristics of carcinogens to support decision-making [PDF]

The key characteristics (KCs) of carcinogens are the properties common to known human carcinogens that can be used to search for, organize, and evaluate mechanistic data in support of hazard identification.
McHale, Cliona M, Rana, Iemaan, Rigutto, Gabrielle, Singam, Ettayapuram Ramaprasad Azhagiya, Smith, Martyn T, Zhang, Luoping   +5 more
core   +1 more source

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer [PDF]

, 2013
Gold OAIntroduction: Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for ...
Aboagye, EO, Ali, S, Anderson, AS, Armes, J, Berditchevski, F, Blaydes, JP, Blaydes, JP, Brennan, K, Brown, NJ, Bryant, HE, Bundred, NJ, Burchell, JM, Campbell, AM, Carroll, JS, Clarke, RB, Coles, CE, Cook, GJR, Cox, A, Curtin, NJ, Dekker, LV, Duffy, SW, Easton, DF, Eccles, DM, Eccles, SA, Edwards, DR, Edwards, J, Evans, DG, Fenlon, DF, Flanagan, JM, Foster, C, Gallagher, WM, Garcia-Closas, M, Gee, JMW, Gescher, AJ, Goh, V, Groves, AM, Harvey, AJ, Harvie, M, Hennessy, BT, Hiscox, S, Holen, I, Howell, A, Howell, SJ, Hubbard, G, Hulbert-Williams, N, Hunter, MS, Jasani, B, Jones, LJ, Key, TJ, Kirwan, CC, Kong, A, Kunkler, IH, Langdon, SP, Leach, MO, Macdougall, JE, Mann, DJ, Marshall, JF, Martin, LA, Martin, SG, Miles, DW, Miller, WR, Morris, JR, Moss, SM, Mullan, P, Natrajan, R, O’Connor, JPB, O’Connor, R, Palmieri, C, Pharoah, PDP, Rakha, EA, Reed, E, Robinson, SP, Sahai, E, Saxton, JM, Schmid, P, Silva, IS, Smalley, MJ, Speirs, V, Stein, R, Stingl, J, Streuli, CH, Thompson, AM, Tutt, ANJ, Velikova, G, Walker, RA, Watson, CJ, Williams, KJ, Young, LS   +87 more
core   +18 more sources