Results 71 to 80 of about 4,373 (237)

Single shot adductor canal block combined with intravenous patient‐controlled analgesia can be effective as continuous adductor canal block in reducing opioid consumption and breakthrough pain after total knee arthroplasty

Journal of Experimental Orthopaedics, 2022
Purpose The aim of this study was to compare the following three analgesic methods after Total knee arthroplasty (TKA): intravenous patient‐controlled analgesia (IV‐PCA), continuous adductor canal block (C‐ACB), and intravenous patient‐controlled ...
Sung Eun Kim, Hyuk‐Soo Han, Myung Chul Lee, Du Hyun Ro   +3 more
doaj   +1 more source

Evolutionary radiation of large‐bodied gorgonopsians from the lower Abrahamskraal formation of South Africa

The Anatomical Record, EarlyView.
Abstract The middle Permian represents a critical interval in therapsid evolution, when gorgonopsians emerged as some of the first specialized apex predators within terrestrial ecosystems. Despite their significance, the early diversification of Gorgonopsia in Gondwana remains poorly understood due to scarcity and fragmentary material.
Zanildo Macungo, Ricardo Araújo, Bruce S. Rubidge, Michael O. Day, Kathleen N. Dollman, Julien Benoit   +5 more
wiley   +1 more source

Gleaning the Rocky Shore? 2500 Years of Coastal Resource Use at Red Bluff 1, GunaiKurnai Country, SE Australia

Archaeology in Oceania, EarlyView.
ABSTRACT Shell middens in Gippsland along the eastern half of Victoria's coastline have usually been characterised as small, short‐duration camp sites with relatively low shell densities and low taxonomic diversity. Here we present new excavation results from a dense, high‐diversity site at Red Bluff near the eastern end of GunaiKurnai Country, a ...
Patrick Faulkner, Bruno David, David M. Kennedy, Fiona Petchey, Joanna Fresløv, Ashleigh J. Rogers, Jillian Garvey, Rachel Kirby, Runjie Yuan, Russell Mullett, John Stanisic, Kyne Krusic‐Golub, V. Ruth Pullin, Matthew C. McDowell, Robert J. Skelly, Anthony Romano, Vanessa N. L. Wong, GunaiKurnai Land and Waters Aboriginal Corporation   +17 more
wiley   +1 more source

Comparative evaluation of ultrasound-guided adductor canal block using levobupivacaine with or without fentanyl for postoperative analgesia in arthroscopic knee surgery: A randomized controlled trial: Levobupivacaine with fentanyl in ACB [PDF]

Serbian Journal of Anesthesia and Intensive Therapy
Introduction: Postoperative pain following knee surgery is often severe and may delay rehabilitation. This study evaluated the safety and efficacy of adding fentanyl to levobupivacaine in ultrasound guided adductor canal block (ACB). Methods: One hundred
Shashikant Maheshwari Bhaarat, Ashokbhai Moradiya Meet, Rameshbhai Shrimali Kulin   +2 more
doaj   +1 more source

Stepwise mitochondria‐targeted photodynamic immunotherapy enabled by an outer membrane vesicles‐based nanoplatform for synergistic tumor ablation and immune reprogramming

Smart Molecules, EarlyView.
We constructed a novel excellent photodynamic drug without heavy atoms based on the conventional BODIPY photosensitizer, and then obtained a photodynamic vesicle with efficient tumor targeting (BDPM@OMVs) by bacterial extravasation. Multiple reactive oxygen species were efficiently generated under light irradiation, and the spontaneous elimination of ...
Xiang Cheng, Ziheng Luo, Ying Yin, Duoyang Fan, Ruyan Xie, Yanpeng Fang, Xiaohui Liu, Dayan Xiong, Wei Liu, Seraphine V. Wegner, Fei Chen, Wenbin Zeng   +11 more
wiley   +1 more source

Continuous Adductor Canal Block used for postoperative pain relief after medial Unicondylar Knee Arthroplasty: a randomized, double-blind, placebo-controlled trial

BMC Anesthesiology, 2019
Background Peripheral nerve block and local infiltration analgesia (LIA) provide good analgesia after knee replacement. This study evaluated the additional analgesic efficacy of continuous adductor canal block (ACB) added to single-dose LIA after medial ...
Fei Lan, Yanyan Shen, Yanhui Ma, Guanglei Cao, Nicole Philips, Ting Zhang, Tianlong Wang   +6 more
doaj   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Integrative Computational and Experimental Approaches Reveal the Protective Role of Moderate Caffeine Intake Against Apical Periodontitis Induced Bone Loss

International Endodontic Journal, EarlyView.
ABSTRACT Aim To investigate whether moderate systemic caffeine intake modulates the progression of apical periodontitis (AP) and associated alveolar bone loss, combining in vivo rat experiments with in silico molecular docking to explore potential mechanisms. Methodology Male Wistar rats were randomly assigned to four groups (n = 8 per group): control,
Matheus Ferreira Lima Rodrigues, Deborah Ribeiro Frazão, Deiweson Souza‐Monteiro, Vinicius Ruan Neves dos Santos, Felipe Oliveira Nunes, João Daniel Mendonça de Moura, Thamires Campos Gomes, Jorddy Neves Cruz, Cristiane do Socorro Ferraz Maia, Rodrigo A. Cunha, Fabrício Mezzomo Collares, Rogerio de Castilho Jacinto, Rafael Rodrigues Lima   +12 more
wiley   +1 more source

Soft tissue abnormalities in the congenital limb malformation radial dysplasia (RD): Their clinical impact and treatment significance

Journal of Anatomy, EarlyView.
We review the characteristic changes to the limb soft tissue and neurovascular abnormalities that have been described in the congenital limb birth defect, Radial Dysplasia. These include consistent changes in muscle anatomy or absence of specific muscles, persistent median arteries and absent radial arteries and consistent alterations in neural ...
Marco Correia Duarte, Sultan M. Al‐Zyoud, Eleanor M. Feneck, Duane James, Gillian D. Smith, Branavan Sivakumar, Malcolm P. O. Logan   +6 more
wiley   +1 more source

Stereospondyl amphibians from the Elliot Formation of South Africa [PDF]

, 1999
This paper documents the first members of the Chigutisauridae (Amphibia, Stereospondyli) from southern Africa and the first post-Triassic stereospondyls from that region.
Damiani, Ross, Warren, Anne
core