Results 31 to 40 of about 199,850 (190)
A Comprehensive Database for DNA Adductomics
Frontiers in Chemistry, 2022 The exposure of human DNA to genotoxic compounds induces the formation of covalent DNA adducts, which may contribute to the initiation of carcinogenesis.
Giorgia La Barbera +4 more
doaj +1 more source
Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design [PDF]
, 2009 The main task of the medicinal chemist is to design molecules that interact specifically with derailed or degenerating processes in a diseased organism, translating the available knowledge of pathobiochemical and physiological data into chemically ...
Bruijnincx, Pieter C. A., Sadler, P. J.
core +1 more source
Alcohol, Aldehydes, Adducts and Airways
Biomolecules, 2015 Drinking alcohol and smoking cigarettes results in the formation of reactive aldehydes in the lung, which are capable of forming adducts with several proteins and DNA.
Muna Sapkota, Todd A. Wyatt
doaj +1 more source
Unusual DNA binding modes for metal anticancer complexes [PDF]
, 2009 DNA is believed to be the primary target for many metal-based drugs. For example, platinum-based anticancer drugs can form specific lesions on DNA that induce apoptosis.
Pizarro, Ana M., Sadler, P. J.
core +1 more source
PharmaceuticalsBoronic acids form diester bonds with cis-hydroxyl groups in carbohydrates. The formation of these adducts could impair the physical and chemical properties of precursors, even their biological activity. Two carbohydrate derivatives from d-fructose and d-
Ricardo Ivan Cordova-Chávez +8 more
doaj +1 more source
Toxins, 2021 Pyrrolizidine alkaloids (PAs) with 1,2-unsaturated necine base are hepatotoxic phytotoxins. Acute PA intoxication is initiated by the formation of adducts between PA-derived reactive pyrrolic metabolites with cellular proteins. The present study aimed to
Jiang Ma +4 more
doaj +1 more source
DNA adducts in fish following an oil spill exposure [PDF]
, 2006 On 12 December 1999, one third of the load of the Erika tanker, amounting to about 10,000 t crude oil flowed into sea waters close to the French Atlantic Coast.
A. Amat +36 more
core +3 more sources
Identification of New Markers of Alcohol-Derived DNA Damage in Humans
Biomolecules, 2021 Alcohol consumption is a risk factor for the development of several cancers, including those of the head and neck and the esophagus. The underlying mechanisms of alcohol-induced carcinogenesis remain unclear; however, at these sites, alcohol-derived ...
Valeria Guidolin +6 more
doaj +1 more source
Direct Identification of Acetaldehyde Formation and Characterization of the Active Site in the [VPO4].+/C2H4 Couple by Gas‐Phase Vibrational Spectroscopy [PDF]
, 2019 The gas‐phase reaction of the heteronuclear oxide cluster [VPO4].+ with C2H4 is studied under multiple collision conditions at 150 K using cryogenic ion‐trap vibrational spectroscopy combined with electronic structure calculations.
Asmis, Knut R. +5 more
core +1 more source
Urine Biomarkers of Risk in the Molecular Etiology of Breast Cancer
Breast Cancer: Basic and Clinical Research, 2009 Endogenous estrogens can be bio-activated to endogenous carcinogens via formation of estrogen quinones. Estrogen-3,4-quinones react with DNA to form mutagenic depurinating estrogen-DNA adducts.
Nilesh W. Gaikwad +6 more
doaj +2 more sources