Results 41 to 50 of about 199,850 (190)

Flanking bases influence the nature of DNA distortion by platinum 1,2-intrastrand (GG) cross-links. [PDF]

PLoS ONE, 2011
The differences in efficacy and molecular mechanisms of platinum anti-cancer drugs cisplatin (CP) and oxaliplatin (OX) are thought to be partially due to the differences in the DNA conformations of the CP and OX adducts that form on adjacent guanines on ...
Debadeep Bhattacharyya, Srinivas Ramachandran, Shantanu Sharma, Wimal Pathmasiri, Candice L King, Irene Baskerville-Abraham, Gunnar Boysen, James A Swenberg, Sharon L Campbell, Nikolay V Dokholyan, Stephen G Chaney   +10 more
doaj   +1 more source

Current and Future Methodology for Quantitation and Site-Specific Mapping the Location of DNA Adducts

Toxics, 2022
Formation of DNA adducts is a key event for a genotoxic mode of action, and their presence is often used as a surrogate for mutation and increased cancer risk.
Gunnar Boysen, Intawat Nookaew
doaj   +1 more source

Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light. [PDF]

, 2018
Water treatment systems frequently use strong oxidants or UV light to degrade chemicals that pose human health risks. Unfortunately, these treatments can result in the unintended transformation of organic contaminants into toxic products.
Ford, Breanna, Nomura, Daniel K, Prasse, Carsten, Sedlak, David L   +3 more
core   +1 more source

Step-Wise Computational Synthesis of Fullerene C60 derivatives. 1.Fluorinated Fullerenes C60F2k

, 2009
The reactions of fullerene C60 with atomic fluorine have been studied by unrestricted broken spin-symmetry Hartree-Fock (UBS HF) approach implemented in semiempirical codes based on AM1 technique. The calculations were focused on a sequential addition of
A. A. Gakh, A. A. Gakh, A. A. Gakh, A. A. Gakh, A. A. Popov, A. Szabo, B. W. Clare, B. W. Clare, B. W. Clare, B. W. Clare, B. W. Clare, D. A. Zhogolev, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. R. Davidson, F. N. Tomilin, H. Zabrodsky, I. Kaplan, I. S. Neretin, J. A. Pople, J. H. Holloway, J. Hachmann, K. B. Wiberg, K. Balasubramania, K. Hedberg, K. Takatsuka, L. G. Bulusheva, L. Hedberg, L. Noodleman, N. Matsuzawa, O. V. Boltalina, O. V. Boltalina, P. J. Krusic, P. K. Berzigiyarov, R. J. Papoular, R. L. Jaffe, R. Mitsumoto, R. Taylor, R. Taylor, S. Dutta, S. G. Semenov, S. Grimme, S. I. Troyanov, S. Kawasaki, U. Barth von, V. N. Staroverov   +54 more
core   +1 more source

Synthesis, characterization, and biological evaluation of some metal complexes containing N and S donor atoms

Results in Chemistry, 2023
Eight new bipyridine adducts of Zn(II) and Ni(II) dithiocarbamate complexes have been prepared from the reaction of Zn(II) and Ni(II) complexes of N-ethyl-N-phenyldithiocarbamate and 4,4′ dipyridine, 4,4′-dimethyl-2,2′-bipyridine, 4,4′-dimethoxy-2,2 ...
Tanzimjahan A. Saiyed, Jerry O. Adeyemi, Moganavelli Singh, Sunday N. Okafor, Damian C. Onwudiwe   +4 more
doaj   +1 more source

Differentiating signals to make biological sense – a guide through databases for MS-based non-targeted metabolomics [PDF]

, 2017
Metabolite identification is one of the most challenging steps in metabolomics studies and reflects one of the greatest bottlenecks in the entire workflow.
Armitage, Emily Grace, Barbas, Coral, Gil de la Fuente, Alberto, Godzien, Joanna, Otero, Abraham   +4 more
core   +1 more source

Composés d'addition des halogénures de niobium(V) et de tantale(V): II. Stabilité relative des composés des chlorures avec quelques éthers, sulfures et nitriles

CHIMIA, 1971
New NMR methods for the determination of relative stability constants are developed. These methods are used for the study of niobium(V) and tantalum(V) chlorides adducts with series of ethers, sulfides, and nitriles. The relative stabilities of nitriles
A. Merbach, J.-C. Bünzli
doaj   +1 more source

Characterization and quantitation of busulfan DNA adducts in the blood of patients receiving busulfan therapy

Molecular Therapy: Oncolytics, 2023
DNA alkylating drugs have been used as cancer chemotherapy with variable outcomes. The establishment of predictive biomarkers to identify patients who will effectively respond to treatment would allow for the development of personalized therapies. As the
Valeria Guidolin, Yupeng Li, Foster C. Jacobs, Margaret L. MacMillan, Peter W. Villalta, Stephen S. Hecht, Silvia Balbo   +6 more
doaj   +1 more source

NAPQI adducts in patients with selective hypersensitivity to acetaminophen

Frontiers in Pharmacology
IntroductionAcetaminophen, a widely used analgesic and antipyretic, can cause adverse reactions ranging from mild urticaria to severe anaphylaxis.
Javier Gomez-Tabales, Jesus M. García-Menaya, Jesus M. García-Menaya, Natalia Blanca-Lopez, María de las Olas Cerezo-Arias, María de las Olas Cerezo-Arias, Antonio Silva-Rodríguez, Pedro Ayuso, Elena García-Martín, José A. G. Agúndez   +9 more
doaj   +1 more source

Interaction of a symmetrical α,α',δ,δ'-Tetramethyl-cucurbit[6]uril with Ln³⁺ : potential applications for isolation of lanthanides [PDF]

, 2016
The interaction of a symmetrical α,α′,δ,δ′-tetramethyl-cucurbit[6]uril (TMeQ[6]) with a series of lanthanide cations (Ln³⁺) was investigated in neutral water and in acidic solution.
Gao, Zhong-Zheng, Lu, Ji-Hong, Prior, Timothy J., Redshaw, Carl, Tao, Zhu, Wei, Gang, Xiao, Xin, Xue, Sai-Feng, Yang, Bo, Zhu, Qian-Jiang   +9 more
core   +1 more source