Results 31 to 40 of about 22,572 (176)
Bufarenogin induces intrinsic apoptosis via Bax and ANT cooperation
Pharmacology Research & Perspectives, 2021 Toads have high medicinal value and have been used for medicinal purposes since the Tang Dynasty period (7th‐10th Century AD). Bufarenogin, an active anti‐tumor constituent of toad venom, shows anti‐tumor activity.
Qinrui Han +5 more
doaj +1 more source
Both ANT and ATPase are essential for mitochondrial permeability transition but not depolarization
iScience, 2022 Summary: An increase in permeability of the mitochondrial inner membrane, mitochondrial permeability transition (PT), is the central event responsible for cell death and tissue damage in conditions such as stroke and heart attack.
M.A. Neginskaya +2 more
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Regulation of the mitochondrial permeability transition pore and its effects on aging
Microbial Cell, 2020 Aging is an evolutionarily conserved process and is tightly connected to mitochondria. To uncover the aging molecular mechanisms related to mitochondria, different organisms have been extensively used as model systems.
Damiano Pellegrino-Coppola
doaj +1 more source
Redox Biology, 2023 Objective: Enhancing energy turnover via uncoupled mitochondrial respiration in adipose tissue has great potential to improve human obesity and other metabolic complications. However, the amount of human brown adipose tissue and its uncoupling protein 1 (
Marie Herrnhold +4 more
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, 2021 Thermogenesis in the appendix of Sauromatum venosum inflorescence can be induced by aspirin, salicylic acid, and 2-6-dihydroxybenzoic acid. The contribution of mitochondrial F0F1 ATP synthase, adenine nucleotide translocator, and alternative oxidase to ...
S. Hanna
semanticscholar +1 more source
Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice
Molecular Metabolism, 2022 Objective: Mitochondrial disorders are often characterized by muscle weakness and fatigue. Null mutations in the heart-muscle adenine nucleotide translocator isoform 1 (ANT1) of both humans and mice cause cardiomyopathy and myopathy associated with ...
Patrick M. Schaefer +8 more
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Molecules, 2021 The permeability transition (PT) is an increased permeation of the inner mitochondrial membrane due to the opening of the PT pore (PTP), a Ca2+-activated high conductance channel involved in Ca2+ homeostasis and cell death.
Andrea Carrer +3 more
doaj +1 more source
iTRAQ-Based Quantitative Proteomics Identifies Potential Regulatory Proteins Involved in Chicken Eggshell Brownness. [PDF]
PLoS ONE, 2016 Brown eggs are popular in many countries and consumers regard eggshell brownness as an important indicator of egg quality. However, the potential regulatory proteins and detailed molecular mechanisms regulating eggshell brownness have yet to be clearly ...
Guangqi Li +5 more
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Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. [PDF]
PLoS ONE, 2008 Type II hexokinase is overexpressed in most neoplastic cells, and it mainly localizes on the outer mitochondrial membrane. Hexokinase II dissociation from mitochondria triggers apoptosis.
Federica Chiara +9 more
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Mitochondrial ATP Synthase and Mild Uncoupling by Butyl Ester of Rhodamine 19, C4R1
Antioxidants, 2023 The homeostasis of the transmembrane potential of hydrogen ions in mitochondria is a prerequisite for the normal mitochondrial functioning. However, in different pathological conditions it is advisable to slightly reduce the membrane potential, while ...
Ljubava D. Zorova +14 more
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