Results 41 to 50 of about 22,572 (176)

Computational identification of transcriptionally co-regulated genes, validation with the four ANT isoform genes

BMC Genomics, 2012
Background The analysis of gene promoters is essential to understand the mechanisms of transcriptional regulation required under the effects of physiological processes, nutritional intake or pathologies.
Dupont Pierre-Yves, Guttin Audrey, Issartel Jean-Paul, Stepien Georges   +3 more
doaj   +1 more source

The Degradation Mechanism of Toxic Atractyloside in Herbal Medicines by Decoction

Molecules, 2013
Atractyloside (ATR) is found in many Asteraceae plants that are commonly used as medicinal herbs in China and other eastern Asian countries. ATR binds specifically to the adenine nucleotide translocator in the inner mitochondrial membrane and ...
Chih-Jui Chang, Anren Hu, Liang-Yu Chen
doaj   +1 more source

Metabolic control analysis of respiration in human cancer tissue

Frontiers in Physiology, 2013
Bioenergetic profiling of cancer cells is of great potential because it can bring forward new and effective therapeutic strategies along with early diagnosis.
Tuuli eKaambre, Vladimir eChekulayev, Igor eShevchuk, Kersti eTepp, Natalja eTimohhina, Minna eVarikmaa, Rafaela eBagur, Aleksandr eKlepinin, Tiia eAnmann, Andre eKoit, Andrus eKaldma, Rita eGuzun, Vahur eValvere, Vahur eValvere, Valdur eSaks, Valdur eSaks   +15 more
doaj   +1 more source

ANT1 overexpression models: Some similarities with facioscapulohumeral muscular dystrophy

Redox Biology, 2022
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disorder characterized by progressive muscle weakness. Adenine nucleotide translocator 1 (ANT1), the only 4q35 gene involved in mitochondrial function, is strongly expressed in FSHD ...
Sandrine Arbogast, Heinrich Kotzur, Corinna Frank, Nathalie Compagnone, Thibault Sutra, Fabien Pillard, Sylvia Pietri, Nisrine Hmada, Daouda Moustapha Abba Moussa, Jamie Bride, Sarah Françonnet, Jacques Mercier, Jean-Paul Cristol, Marie-Christine Dabauvalle, Dalila Laoudj-Chenivesse   +14 more
doaj   +1 more source

HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT. [PDF]

PLoS Pathogens, 2006
The HIV-1 accessory protein viral protein R (Vpr) causes G2 arrest and apoptosis in infected cells. We previously identified the DNA damage-signaling protein ATR as the cellular factor that mediates Vpr-induced G2 arrest and apoptosis.
Joshua L Andersen, Jason L DeHart, Erik S Zimmerman, Orly Ardon, Baek Kim, Guillaume Jacquot, Serge Benichou, Vicente Planelles   +7 more
doaj   +1 more source

Cyclophilin D Contributes to Anesthesia Neurotoxicity in the Developing Brain

Frontiers in Cell and Developmental Biology, 2020
Anesthetic sevoflurane induces mitochondrial dysfunction, impairment of neurogenesis, and cognitive impairment in young mice, but the underlying mechanism remains to be determined.
Yiying Zhang, Yiying Zhang, Pan Lu, Feng Liang, Ning Liufu, Yuanlin Dong, Jialin Charles Zheng, Jialin Charles Zheng, Zhongcong Xie   +8 more
doaj   +1 more source

Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction

The FEBS Journal, EarlyView.
Dietary and genetic stress trigger different routes to heart failure. In mice, a carbohydrate‐free high‐fat diet caused mitochondrial dysfunction and impaired energy production with preserved pumping function, while genetic obesity led to heart enlargement, fibrosis, and reduced function.
Christiane Ott, Patricia Baumgarten, Thorsten Henning, Daniela Weber, Iwona Wallach, Jana Grune, Ulrich Kintscher, Hermann‐Georg Holzhütter, Tilman Grune, Nikolaus Berndt   +9 more
wiley   +1 more source

Fluorescent reporter of Caenorhabditis elegans Parkin: Regulators of its abundance and role in autophagy-lysosomal dynamics [version 2; peer review: 2 approved]

Open Research Europe, 2023
Background: Parkin, which when mutated leads to early-onset Parkinson’s disease, acts as an E3 ubiquitin ligase. How Parkin is regulated for selective protein and organelle targeting is not well understood.
Kathy H. Li, Bingying Wang, Roman Vozdek, Andrew A. Hicks, Peter P. Pramstaller, Dengke K. Ma   +5 more
doaj   +1 more source

Functional Insights on the Human Adenine Nucleotide Translocator Interactome

The FASEB Journal, 2017
The adenine nucleotide translocator (ANT), by mediating the exchange of ADP for ATP across the inner mitochondrial membrane, lies at the core of oxidative phosphorylation (OXPHOS).
M. Acoba, Ya-Wen Lu, Selvaraju Kandasamy, Tai‐Chung Huang, R. Nirujogi, Akhilesh Pandey, S. Claypool   +6 more
semanticscholar   +1 more source

Progressive Alteration of UCP and ANT in Skeletal Muscle of Fasted Chickens

The Journal of Poultry Science, 2006
Avian uncoupling protein (avUCP), sharing 71-73% amino acid homology with both UCP2 and UCP3, is one of the mitochondrial anion carrier proteins. Its precise physiological roles in the cell remain elusive.
Masaaki Toyomizu, Tomoki Abe, Masatoshi Ueda, Yukio Akiba   +3 more
doaj   +1 more source