Results 51 to 60 of about 22,572 (176)

Peroxisome proliferator-activated receptor gamma upregulation and dietary fat levels in laying hens

Poultry Science, 2021
The present study was conducted to investigate the effect of feeding the different levels of the dietary fat on the expression of genes encoding proteins involving energy metabolism, oxidative phosphorylation, and lipid synthesis including peroxisome ...
Shahram Barzegar, Robert A. Swick, Sarbast K. Kheravii, Mingan Choct, Shu-Biao Wu   +4 more
doaj   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

Mechanism of the Protective Effect of Yulangsan Flavonoid on Myocardial Ischemia/Reperfusion Injury in Rats

Cellular Physiology and Biochemistry, 2014
Aims: Effect and mechanism of Yulangsan flavonoid (YLSF) on rat myocardial ischemia/reperfusion injury (MI/RI) has been investigated. Methods: Sprague-Dawley (SD) rats were randomly divided into seven groups (sham group, model group and NS group: 2 mL of
Xudong Zhang, Xingmei Liang, Xing Lin, Shijun Zhang, Zhongshi Huang, Chunxia Chen, Youjia Guo, Feifei Xuan, Xiaohui Xu, Renbin Huang   +9 more
doaj   +1 more source

The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha, Danielle Twilley, Mona Dawood, Thomas Efferth, Namrita Lall   +4 more
wiley   +1 more source

Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1.

PLoS Pathogens, 2005
The influenza virus PB1-F2 is an 87-amino acid mitochondrial protein that previously has been shown to induce cell death, although the mechanism of apoptosis induction has remained unclear.
Dmitriy Zamarin, Adolfo García-Sastre, Xiaoyao Xiao, Rong Wang, Peter Palese   +4 more
doaj   +2 more sources

Bongkrekic acid facilitates glycolysis in cultured cells and induces cell death under low glucose conditions

Biochemistry and Biophysics Reports, 2019
Bongkrekic acid (BKA) inhibits adenine nucleotide translocator (ANT) and suppresses ADP/ATP exchange in the mitochondrial inner membrane. Previously, we demonstrated that BKA exhibited cytotoxic effects on 4T1 tumor cells, depending on the cell number in
Arihiro Kano, Takuma Iwasaki, Mitsuru Shindo   +2 more
doaj   +1 more source

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

Medicinal Research Reviews, Volume 46, Issue 1, Page 238-271, January 2026.
ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg, Tracie Widjaja, Adriaan P. IJzerman, Daan van der Es   +3 more
wiley   +1 more source

Ciliary Neurotrophic Factor (CNTF) Protects Myocardial Cells from Oxygen Glucose Deprivation (OGD)/Re-Oxygenation via Activation of Akt-Nrf2 Signaling

Cellular Physiology and Biochemistry, 2018
Background/Aims: Oxygen glucose deprivation (OGD)/re-oxygenation (OGDR) exposure to myocardial cells mimics ischemia-reperfusion injuries. We studied the potential activity of ciliary neurotrophic factor (CNTF) on OGDR-treated myocardial cells.
Koulong Zheng, Qing Zhang, Zhenqiang Sheng, Yefei Li, Hui-he Lu   +4 more
doaj   +1 more source

Mitochondria‐Associated Endoplasmic Reticulum Membranes as Potential Therapeutic Targets in Epilepsy

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
MAMs are involved in the occurrence and development of epilepsy through calcium ion homeostasis imbalance, mitochondrial dysfunction, endoplasmic reticulum stress and inflammation, abnormal lipid metabolism, as well as autophagy and mitochondrial autophagy. This picture was drawn using Figdraw.
Huaiyu Sun, Xuewei Li, Weixuan Zhao, Wuqiong Zhang, Hongmei Meng   +4 more
wiley   +1 more source

Computational modelling of myocardial metabolism in patients with advanced heart failure

European Journal of Heart Failure, Volume 27, Issue 12, Page 3411-3422, December 2025.
Study design and key findings. Proteomics‐informed, patient‐specific computational models of myocardial metabolism reveal reduced ATP production capacity and a lower fatty acid‐to‐glucose utilisation ratio in heart failure, which correlated with functional recovery following mechanical unloading.
Niklas Beyhoff, Vera M. Braun, Marieluise Kirchner, Lucy E.M. Finnigan, Christoph Knosalla, István Baczkó, Evgenij Potapov, Ulrich Kintscher, Tilman Grune, Titus Kuehne, Hermann‐Georg Holzhütter, Philipp Mertins, Damian J. Tyler, Hendrik Milting, Betty Raman, Oliver J. Rider, Stefan Neubauer, Nikolaus Berndt   +17 more
wiley   +1 more source