Results 61 to 70 of about 22,572 (176)

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Mitochondrial pathway mediates the antileukemic effects of Hemidesmus indicus, a promising botanical drug. [PDF]

PLoS ONE, 2011
BackgroundAlthough cancers are characterized by the deregulation of multiple signalling pathways, most current anticancer therapies involve the modulation of a single target.
Carmela Fimognari, Monia Lenzi, Lorenzo Ferruzzi, Eleonora Turrini, Paolo Scartezzini, Ferruccio Poli, Roberto Gotti, Alessandra Guerrini, Giovanni Carulli, Virginia Ottaviano, Giorgio Cantelli-Forti, Patrizia Hrelia   +11 more
doaj   +1 more source

PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins. [PDF]

PLoS ONE, 2010
BACKGROUND: The hallmark of HIV-1 pathogenesis is the progressive CD4(+) T cell depletion and high propensity of CD4(+) T cells to apoptosis. HIV-1 viral protein R (Vpr) is a major pro-apoptotic gene product. A first Vpr-mediated apoptotic mechanism that
Angélique N Godet, Julien Guergnon, Amélie Croset, Xavier Cayla, Pierre Barthélemy Falanga, Jean-Hervé Colle, Alphonse Garcia   +6 more
doaj   +1 more source

Epitranscriptomic reprogramming in response to low CO2 stress and m6A engineering to enhance biomass production in Nannochloropsis oceanica

The Plant Journal, Volume 124, Issue 3, November 2025.
Significance Statement Dynamic N6‐adenine methylation (m6A) regulates CO2‐responsive gene expression in Nannochloropsis oceanica. Genome editing of methylases NoMTA and NoMTB triggers m6A reprogramming, and CRISPR/dCas13‐based m6A engineering modulates stress tolerance and biomass production, unveiling an epitranscriptomic mechanism in microalgae ...
Han Zhu, Yikai Wu, Meng Feng, Lingyu Ouyang, Hang Su, Li Wei   +5 more
wiley   +1 more source

N-acetylcysteine protects septic acute kidney injury by inhibiting SIRT3-mediated mitochondrial dysfunction and apoptosis [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): To investigate the protective effect of N-acetylcysteine (NAC) on septic acute kidney injury (SAKI) via regulating Sirtuin3 (SIRT3)-mediated mitochondrial dysfunction and apoptosis.Materials and Methods: By constructing SIRT3 knockout mice ...
Heng Fan, Le Jian-wei, sun Min, Zhu Jian-hua   +3 more
doaj   +1 more source

Natural Mutation in Naked Mole‐Rat UCP1 Refutes Importance of the Histidine Pair Motif for Proton Conductance and Thermogenesis

Acta Physiologica, Volume 241, Issue 10, October 2025.
ABSTRACT Aim Uncoupling protein 1 (UCP1) is the crucial protein for non‐shivering thermogenesis in placental mammals, but the molecular mechanism of thermogenic proton transport is still unknown. Its histidine pair motif (H145 and H147) has been claimed as a critical element for proton translocation, leading to the paradigmatic “cofactor model” of the ...
Michael J. Gaudry, Amanda Bundgaard, Maria Kutschke, Klaudia Ostatek, Margeoux A. S. Dela Rosa, Paul G. Crichton, Jane Reznick, Martin Jastroch   +7 more
wiley   +1 more source

A Critical Review on BH3 Mimetic Drugs and the Treatment of Cancer‐Associated Thrombosis (CAT): A Proposed Design for a Drug Delivery System Capable of Simultaneously Targeting Tumor Cells and Activated Platelets

Cancer Medicine, Volume 14, Issue 18, September 2025.
Targeting Cancer associated thrombosis (CAT): The left panel (A) shows cancer‐associated thrombosis with activated platelets expressing αIIbβ3 in close contact with tumoral vasculature expressing αvβ3 integrin, where both cells release a significant amount of thrombin.
Mehran Ghasemzadeh, Nazanin Heidari, Jalal Naghinezhad, Alireza Ghasemzadeh, Ehteramolsadat Hosseini   +4 more
wiley   +1 more source

Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: Role of GSK-3β in Myocardial Protection Against Ischemia/Reperfusion Injury

Journal of Pharmacological Sciences, 2009
Although reperfusion is required to salvage ischemic myocardium from necrosis, reperfusion per se induces myocardial necrosis. In this “lethal reperfusion injury”, opening of the mitochondrial permeability transition pore (mPTP) upon reperfusion is ...
Tetsuji Miura, Masahiro Nishihara, Takayuki Miki   +2 more
doaj   +1 more source

Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function

European Journal of Heart Failure, Volume 27, Issue 9, Page 1720-1736, September 2025.
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard, Mahmoud Abdellatif, Ioanna Andreadou, Christian Bär, Luc Bertrand, Bianca J.J.M. Brundel, Gemma Chiva‐Blanch, Sean M. Davidson, Dana Dawson, Fabio Di Lisa, Paul Evans, Zoltan Giricz, Derek J. Hausenloy, Petra Kleinbongard, Frank Lezoualc'h, Elisa Liehn, Christoph Maack, Ange Maguy, Elizabeth Murphy, Cinzia Perrino, Maurizio Pesce, Peter P. Rainer, Katrin Streckfuss‐Bömeke, Matthias Thielmann, Rong Tian, Carlo G. Tocchetti, Jolanda Van Der Velden, Sophie Van Linthout, Serena Zacchigna, Thomas Krieg   +29 more
wiley   +1 more source

A toolset of constitutive promoters for metabolic engineering of Rhodosporidium toruloides

Microbial Cell Factories, 2019
Background Rhodosporidium toruloides is a promising host for the production of bioproducts from lignocellulosic biomass. A key prerequisite for efficient pathway engineering is the availability of robust genetic tools and resources.
Luísa Czamanski Nora, Maren Wehrs, Joonhoon Kim, Jan-Fang Cheng, Angela Tarver, Blake A. Simmons, Jon Magnuson, Miranda Harmon-Smith, Rafael Silva-Rocha, John M. Gladden, Aindrila Mukhopadhyay, Jeffrey M. Skerker, James Kirby   +12 more
doaj   +1 more source