Results 101 to 110 of about 117,318 (358)
Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy. [PDF]
PLoS ONE, 2009 BACKGROUND:The gene for methylthioadenosine phosphorylase (MTAP) lies on 9p21, close to the gene CDKN2A that encodes the tumor suppressor proteins p16 and p14ARF.
Martin Lubin, Adam Lubin
doaj +1 more source
Advanced Science, EarlyView.In early cold response, MdICE1L utilizes MdHB7L as a cofactor to facilitate the transcriptional activation of MdCBFs, thereby activating cold signaling rapidly and strongly. Subsequently, MdICE1L is degraded by MdHOS1. Meanwhile, MdHB7L is released and accumulates.
Jie Yang +8 more
wiley +1 more source
Beyond Structure: Methylation Fine‐Tunes Stability and Folding Kinetics of bcl2Mid G‐Quadruplex
Angewandte Chemie, EarlyView.The introduction of a single 5‐methylcytosine into a G‐rich sequence originating from the B‐cell lymphoma 2 (BCL2) gene promoter affects both the folding kinetics and thermodynamics of the two G4 structures and thus plays a crucial role in regulating G4 folding pathways, which has significant implications for the control of gene expression.
Nataša Medved +5 more
wiley +2 more sources
A Biophysical Model of the Mitochondrial ATP-Mg/Pi Carrier [PDF]
, 2012 Mitochondrial adenine nucleotide (AdN) content is regulated through the Ca2+-activated, electroneutral ATP-Mg/Pi carrier (APC). The APC is a protein in the mitochondrial carrier super family that localizes to the inner mitochondrial membrane (IMM).
arxiv +1 more source
Influence of the environment and probes on rapid DNA sequencing via transverse electronic transport [PDF]
, 2007 We study theoretically the feasibility of using transverse electronic transport within a nanopore for rapid DNA sequencing. Specifically, we examine the effects of the environment and detection probes on the distinguishability of the DNA bases.
Akeson +44 more
core +3 more sources
Advanced Science, EarlyView.It is reported that Fn14 inhibited EOC metastasis by regulating Slug‐mediated EMT. Furthermore, Fn14 altered the subcellular localization of SIRT2 by interacting with SIRT2, leading to reduced SIRT2 shuttling into the nucleus and subsequently promoting the acetylated degradation of Slug.
Anyue Wu +9 more
wiley +1 more source
Frontiers in ImmunologyNext to white and brown adipocytes present in white and brown adipose tissue (WAT, BAT), vascular endothelial cells, tissue-resident macrophages and other immune cells have important roles in maintaining adipose tissue homeostasis but also contribute to ...
Michelle Y. Jaeckstein +6 more
doaj +1 more source
Development and Breeding of Herbicide‐Resistant Sorghum for Effective Cereal‐Legume Intercropping
Advanced Science, EarlyView.This study identified two SbALS mutations (A93T and S624N) conferring robust herbicide resistance in sorghum, facilitating efficient weed control. Structural analysis revealed that imazamox resistance is mediated by disrupted herbicide binding. Furthermore, 126 imazamox resistant soybean varieties are screened for sorghum‐soybean intercropping ...
Sanyuan Tang +20 more
wiley +1 more source
Clinics, 2011 OBJECTIVES: Aerobic exercise training prevents cardiovascular risks. Regular exercise promotes functional and structural adaptations that are associated with several cardiovascular benefits. The aim of this study is to investigate the effects of swimming
Fernanda R. Roque +7 more
doaj +1 more source
A flexible model-based framework for robust estimation of mutational signatures [PDF]
arXiv, 2022 Somatic mutations in cancer can be viewed as a mixture distribution of several mutational signatures, which can be inferred using non-negative matrix factorization (NMF). Mutational signatures have previously been parametrized using either simple mono-nucleotide interaction models or general tri-nucleotide interaction models. We describe a flexible and
arxiv