Results 211 to 220 of about 644,554 (330)

Reduced Mitochondrial Adenine Nucleotide Translocase 1 (ANT1) Correlates With Aging‐Associated Airway Remodeling

open access: yesAging Cell, EarlyView.
Adenine nucleotide translocase 1 (ANT1), a mitochondrial ATP transporter, is decreased in the lung epithelium of aged adults and aged mice correlating to pathogenic airway changes. Loss of ANT1 correlates with increased cellular senescence and changes in COL8A1 in the airway epithelium of the lung.
Roshani Jha   +5 more
wiley   +1 more source

A disulfidptosis‐related gene signature predicts prognosis and immune‐metabolic landscape in multiple myeloma

open access: yesBritish Journal of Haematology, EarlyView.
Summary Disulfidptosis is a newly recognized cell death induced by disulphide stress under glucose deprivation. However, its clinical implications in multiple myeloma (MM) remain largely unexplored. We identified disulfidptosis‐related genes via co‐expression analysis and developed a risk signature through univariate Cox, least absolute shrinkage and ...
Li Wang   +4 more
wiley   +1 more source

Precursor RNA structural patterns at SF3B1 mutation sensitive cryptic 3' splice sites. [PDF]

open access: yesRNA Biol
Herbert A   +5 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

open access: yesBritish Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Systems modeling and uncertainty quantification of AMP-activated protein kinase signaling. [PDF]

open access: yesNPJ Syst Biol Appl
Linden-Santangeli N   +3 more
europepmc   +1 more source

Comparative metabolomic and transcriptomic analysis of 2D and 3D mesenchymal stem cell cultures for improved therapeutic applications

open access: yesBritish Journal of Pharmacology, EarlyView.
Comparative metabolomic and transcriptomic profiling reveals distinct metabolic shifts and reduced proliferation in 3D MSC spheroids, providing insights to optimise MSC‐based therapies. Abstract Background and Purpose Mesenchymal stem cells (MSCs) are used widely in regenerative medicine due to their multipotency and immunomodulatory properties ...
Manju Shrestha   +7 more
wiley   +1 more source

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