Results 261 to 270 of about 117,318 (358)

IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target

Cell Proliferation, EarlyView.
IMPDH2 is a rate‐limiting enzyme in guanine nucleotide biosynthesis. It plays diverse roles in various physiological and pathological processes: nucleotide metabolism, inflammation, immune function, ribosomal stress. Structural or regulatory alterations in IMPDH2 are linked to significant health issues, and critical relevance in disease progression. We
Zheng Li, Yunpeng Zou, Jiayao Niu, Ying Zhang, Aohua Yang, Wenyu Lin, Jie Guo, Shuya Wang, Ronghan Liu   +8 more
wiley   +1 more source

Proton conductance by human uncoupling protein 1 is inhibited by purine and pyrimidine nucleotides. [PDF]

EMBO J
Jones SA, Sowton AP, Lacabanne D, King MS, Palmer SM, Zögg T, Pardon E, Steyaert J, Ruprecht JJ, Kunji ERS.   +9 more
europepmc   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

Field-Effect Transistor Based on Nanocrystalline Graphite for DNA Immobilization. [PDF]

Biomolecules
Adiaconita B, Chiriac E, Burinaru T, Marculescu C, Pachiu C, Brincoveanu O, Simionescu O, Avram M.   +7 more
europepmc   +1 more source

piRNA processing within non‐membrane structures is governed by constituent proteins and their functional motifs

The FEBS Journal, EarlyView.
The silencing of transposable elements is mediated by piRNAs through post‐transcriptional and transcriptional regulation. In Drosophila, piRNAs are processed within unique non‐membrane structures: nuage in germline cells and Yb bodies in somatic gonadal cells.
Ritsuko Suyama, Toshie Kai
wiley   +1 more source

Non-Target Metabolomics Reveals Changes in Metabolite Profiles in Distant Hybrid Incompatibility Between <i>Paeonia</i> sect. <i>Moutan</i> and <i>P. lactiflora</i>. [PDF]

Plants (Basel)
Jia W, Yu Y, Mi Z, Zhang Y, Zhao G, Guo Y, Wang Z, Wang E, He S.   +8 more
europepmc   +1 more source

Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response

The FEBS Journal, EarlyView.
A targeted mass spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy. We demonstrated a broad shift in the circulating stress‐relevant plasma metabolome associated with stressful scruff handling that was ...
Erynn E. Johnson, James M. Ervasti
wiley   +1 more source

Transformer-based deep learning for accurate detection of multiple base modifications using single molecule real-time sequencing. [PDF]

Commun Biol
Hu X, Shi Y, Cheng SH, Huang Z, Zhou Z, Shi X, Zhang Y, Liu J, Ma ML, Ding SC, Deng J, Qiao R, Peng W, Choy LYL, Yu SCY, Lam WKJ, Chan KCA, Li H, Jiang P, Lo YMD.   +19 more
europepmc   +1 more source

Bacterial transcriptional repressor NrdR – a flexible multifactorial nucleotide sensor

The FEBS Journal, EarlyView.
NrdR is a bacterial transcription factor that regulates the expression of all three types of ribonucleotide reductase, an essential enzyme for cell survival, in response to intracellular ATP and dATP levels. We have carried out a comprehensive biochemical, biophysical and structural study of the response of E. coli NrdR to ATP and dATP.
Inna Rozman Grinberg, Ornella Bimaï, Saher Shahid, Lena Philipp, Markel Martínez‐Carranza, Ipsita Banerjee, Daniel Lundin, Pål Stenmark, Britt‐Marie Sjöberg, Derek T. Logan   +9 more
wiley   +1 more source

Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition

The FEBS Journal, EarlyView.
The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda, Karine Alvarez, Benjamin Morin, Bruno Canard, François Ferron, Nadia Rabah   +5 more
wiley   +1 more source