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Receptors for adenosine and adenine nucleotides

General Pharmacology: The Vascular System, 1991
1. A summary is provided of current classifications of receptors for the adenine nucleosides and nucleotides. 2. The origin of the division of nucleoside (P1) and nucleotide (P2) receptors is discussed as well as the subdivisions of these into A1 and A2, determined by structure activity considerations, and P2x and P2y. 3.
openaire   +2 more sources

Engineering a precise adenine base editor with minimal bystander editing

Nature Chemical Biology, 2022
Liang Chen   +23 more
semanticscholar   +1 more source

The adenine nucleotide translocator and the nucleotide specificity of oxidative phosphorylation

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1970
Abstract By studying P/O ratios, proton translocation and morphology of different mitochondrial preparations, it was shown, in agreement with previous work but in disagreement with a recent report, that the nucleotide specificity of the oxidative phosphorylation resides at the level of the adenine nucleotide translocator.
J.H.M. Souverijn   +3 more
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Measurement of Adenine Nucleotides

1975
Classically the autonomic nervous system consists of two components, adrenergic and cholinergic nerves. There have been a number of reports of a third nerve component in the autonomic nervous system which is neither adrenergic nor cholinergic and evidence has been presented that the transmitter released from these nerves, at least in the ...
openaire   +2 more sources

Effect of adenine nucleotides on reactions involving triphosphopyridine nucleotide

Biochimica et Biophysica Acta, 1955
Oxidized TPN, and P-ADPR have been found to be competitive inhibitors of the TPNH-cytochrome c reductase of horse liver. 2′ AMP also competitively inhibits, at somewhat higher concentrations. DPN, ADPR, desamino TPN, 3′ AMP, 5′ AMP, 2′ IMP, and 3′ IMP produce very slight or no inhibition.
Elizabeth F. Neufeld   +2 more
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Effects of Adenine Nucleotides on Renal Metabolism

Nephron, 1969
Regulatory effects which adenine nucleotides are known to exert on glycolysis and gluconeogenesis have been demonstrated in the isolated perfused rat kidney and in kidney cortex slices.
H.A. Krebs, D. A. Hems, M.J. Weidemann
openaire   +3 more sources

Discovery of a natural thiamine adenine nucleotide

Nature Chemical Biology, 2007
Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon ...
Tiziana Gigliobianco   +9 more
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Adenine nucleotide degradation in the rabbit heart

American Journal of Physiology-Legacy Content, 1964
Adenine nucleotide analysis of tissue and perfusates of the isolated rabbit heart were undertaken following hypoxia and uncoupled oxidative phosphorylation. During uncoupled oxidative phosphorylation, nucleotide degradation, primarily that of ATP, was three times as great as that observed during hypoxia.
Leigh Wyborny, Harold G. Richman
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Adenosine and Adenine Nucleotides As Regulators of Cellular Function

, 1991
INTRODUCTION. Historical Perspectives-Adenosine (D.J. Cushing and S.J. Mustafa). Historical Perspectives-ATP (D. Satchell). PURINE RECEPTORS, METABOLISM, RELEASE, AND TRANSPORT. Adenosine Receptors: Ligand-Binding Studies (U. Schwabe).
J. Phillis
semanticscholar   +1 more source

Regeneration of Adenine Nucleotides in the Heart

1988
The fast adenine nucleotide degradation, which takes place in the ischemic heart, contrasts with the slow regeneration after ischemia.
J. W. de Jong, P. van der Meer
openaire   +2 more sources

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