Results 141 to 150 of about 110,488 (256)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Chronic sleep deprivation promotes drug‐resistant epilepsy via the BMAL1‐mTOR‐P‐gp axis

Epilepsia Open, EarlyView.
Abstract Objective The interplay between chronic sleep deprivation and drug‐resistant epilepsy (DRE) has gained increasing attention. Brain and muscle Arnt‐like protein 1 (BMAL1), which is implicated in sleep disturbance, has an unclear role in DRE. We aimed to investigate the role of BMAL1 in sleep deprivation‐induced DRE. Methods A pentylenetetrazole
Xiaomeng Wang, Rui Li, Yuzhu Zhang, Yi Hu, Jingjiao Chen, Sijia Tian, Dong Zhou, Xiaosa Chi   +7 more
wiley   +1 more source

An Expanded Toolbox for Versatile Chemical Editing of Adeno-Associated Virus. [PDF]

Angew Chem Int Ed Engl
Pham Q, Glicksman J, Han B, Koo D, Loynd C, Singha Roy SJ, Chatterjee A.   +6 more
europepmc   +1 more source

Engineering of High-Yield Recombinant Adeno-Associated Virus Producer Plasmids. [PDF]

Biotechnol J
Radukic MT, Le DT, Freudenberg R, Hammann A, Hamdan O, Rothschild-Gronau C, Hoffrogge R, Golm SK, Feiner RC, Teschner KE, Müller KM.   +10 more
europepmc   +1 more source

An Improved Method for Determining the Infection Titer of Replication-Competent Adeno-Associated Virus. [PDF]

Biomedicines
Fu J, Yu L, Fu Z, Wang G, Liang C, Shi X, Zhang Y.   +6 more
europepmc   +1 more source

Characterization of adeno-associated virus binding to alginate and its controlled release. [PDF]

Nanoscale Adv
Amante JJ, Mandeville JR, Hargrove H, Zhang XF, Kearney CJ.   +4 more
europepmc   +1 more source

Nationwide audit of cervical cancer screening reveals unsatisfactory triage strategies and trends over time in incidence among cytology negative women

International Journal of Cancer, EarlyView.
What's New? This population‐based cohort study aimed to demonstrate how annual audits of all aspects of the cervical cancer screening pathway can be performed using register national data with clinical validation to identify patterns of risk and inform program change.
Cecilia Kärrberg, Penelope Gray, Kristina Elfgren, Hanna Milerad, Bengt Andrae, Jiayao Lei, Pär Sparén, Joakim Dillner, Jiangrong Wang, K. Miriam Elfström   +9 more
wiley   +1 more source

Lyophilization of Adeno-Associated Virus Serotypes for Storage and Global Distribution. [PDF]

Biomedicines
McGlinch EB, Mudrick HE, Evans CH, Barry MA.   +3 more
europepmc   +1 more source

Generation of Allogeneic CAR‐T Circumvents Functional Deficits in Patient‐Derived Autologous Product for Glioblastoma

International Journal of Cancer, EarlyView.
Clinical trials of chimeric antigen receptor T‐cell (CAR‐T) therapies in glioblastoma have shown limited clinical benefits. Whether this may be explained by the basal quality of CAR‐T products, which are currently generated using patient, autologous T‐cells, has been little explored.
Sabra K. Salim, Muhammad Vaseem Shaikh, Jeffrey Wei, William T. Maich, Alisha Anand, Oliver Y. Tang, Minomi K. Subapanditha, Zahra Alizada, Yujin Suk, Manoj Singh, Kui Zhai, Aapti Khanna, Benjamin Brakel, Vassil Dimitrov, Zoya Tabunshchyk, Katie Chan, Kevin R. Brown, Parvez Vora, Donald M. O'Rourke, Zev A. Binder, Chitra Venugopal, Jason Moffat, Sheila K. Singh   +22 more
wiley   +1 more source

Adeno-Associated Virus Toxicity in Duchenne Muscular Dystrophy: Mechanisms and Clinical Considerations. [PDF]

Genes (Basel)
Saylam E, D'ambrosio ES, Pesco MT, Gushchina LV.   +3 more
europepmc   +1 more source