Results 1 to 10 of about 8,933,423 (298)

Terminal glucose as a receptor for adeno-associated virus 44.9 [PDF]

Journal of Virology
The isolation of novel adeno-associated virus (AAV) serotypes has led to significant advances in our understanding of parvovirus biology and vector development for gene therapy by identifying isolates with unique cell tropism and increased efficiency of ...
Giovanni Di Pasquale, Hemon Tehrani, Ida Shinder, Sandra Afione, John A. Chiorini   +4 more
doaj   +2 more sources

Adeno-associated virus receptor complexes and implications for adeno-associated virus immune neutralization

Frontiers in Microbiology, 2023
Adeno-associated viruses (AAV) are among the foremost vectors for in vivo gene therapy. A number of monoclonal antibodies against several serotypes of AAV have previously been prepared.
Edward E. Large, Michael S. Chapman
doaj   +3 more sources

Fluorescence Microscopy in Adeno-Associated Virus Research

Viruses, 2023
Research on adeno-associated virus (AAV) and its recombinant vectors as well as on fluorescence microscopy imaging is rapidly progressing driven by clinical applications and new technologies, respectively.
Susanne K. Golm, Wolfgang Hübner, Kristian M. Müller   +2 more
doaj   +3 more sources

A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis [PDF]

International Journal of Nanomedicine, 2012
Wei Shao1, Arghya Paul1, Sana Abbasi1, Parminder S Chahal2, Jimmy A Mena2, Johnny Montes2, Amine Kamen2, Satya Prakash11Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Artificial Cells and Organs ...
Shao W, Paul A, Abbasi S, Chahal PS, Mena JA, Montes J, Kamen A, Prakash S   +7 more
doaj   +2 more sources

Protein Carrier Adeno-Associated Virus. [PDF]

ACS Nano
Adeno-associated virus (AAV) has emerged as a leading platform for gene therapy, enabling the delivery of therapeutic DNA to target cells. However, the potential of AAV to deliver protein payloads has been unexplored. In this study, we engineered a protein carrier AAV (pcAAV) to package and deliver proteins by inserting binding domains on the interior ...
Hoffmann MD, Sorensen RJ, Extross A, He Y, Schmidt D.   +4 more
europepmc   +3 more sources

Sclerosing Sialadenitis Is Associated With Salivary Gland Hypofunction and a Unique Gene Expression Profile in Sjögren’s Syndrome

Frontiers in Immunology, 2021
PurposeTo develop a novel method to quantify the amount of fibrosis in the salivary gland and to investigate the relationship between fibrosis and specific symptoms associated with Sjögren’s syndrome (SS) using this method.Materials and MethodsParaffin ...
Hongen Yin, Thomas J. F. Pranzatelli, Benjamin N. French, Nan Zhang, Blake M. Warner, John A. Chiorini, NIDCD/NIDCR Genomics and Computational Biology Core   +6 more
doaj   +1 more source

Advancing Luciferase-Based Antibody Immunoassays to Next-Generation Mix and Read Testing

Biosensors, 2023
Antibody measurements play a central role in the diagnosis of many autoimmune and infectious diseases. One antibody detection technology, Luciferase Immunoprecipitation Systems (LIPS), utilizes genetically encoded recombinant luciferase antigen fusion ...
Peter D. Burbelo, Youngmi Ji, Michael J. Iadarola   +2 more
doaj   +1 more source

Correction of LAMP3-associated salivary gland hypofunction by aquaporin gene therapy

Scientific Reports, 2022
Sjögren’s disease (SjD) is a chronic autoimmune sialadenitis resulting in salivary gland hypofunction with dry mouth symptom. Previous studies showed that lysosome-associated membrane protein 3 (LAMP3) overexpression is involved in the development of ...
Hiroyuki Nakamura, Tsutomu Tanaka, Changyu Zheng, Sandra A. Afione, Blake M. Warner, Masayuki Noguchi, Tatsuya Atsumi, John A. Chiorini   +7 more
doaj   +1 more source

Sarcopenia and coexistent risk factors detected using the ‘Yubi-wakka’ (finger-ring) test in adults aged over 65 years in the public annual health check-up in Tama City, Tokyo: a cross-sectional study

BMJ Open, 2022
Objectives To examine the positive rate of sarcopenia using the ‘Yubi-wakka’ (finger-ring) test and associated risk factors among adults aged 65 years and older.Design Cross-sectional study.Setting We used the Yubi-wakka test, which has been developed ...
Hiroyuki Nakamura, Hitomi Fujii, Eitaro Kodani, Tomohiro Kaneko, Hajime Sasabe, Yutaka Tamura   +5 more
doaj   +1 more source

Development of Therapies for Spinal Muscular Atrophy Using Gene Therapy and Nanotechnology [PDF]

, 2013
Spinal muscular atrophy (SMA) is a genetic disease which is characterized by muscle weakness and atrophy. The disease arises from mutations in the survival motor neuron 1 (SMN1) gene causing degeneration of spinal cord motor neurons.
Little, Daniel
core   +6 more sources