Results 1 to 10 of about 110,545 (302)

Terminal glucose as a receptor for adeno-associated virus 44.9 [PDF]

Journal of Virology
The isolation of novel adeno-associated virus (AAV) serotypes has led to significant advances in our understanding of parvovirus biology and vector development for gene therapy by identifying isolates with unique cell tropism and increased efficiency of ...
Giovanni Di Pasquale, Hemon Tehrani, Ida Shinder, Sandra Afione, John A. Chiorini   +4 more
doaj   +2 more sources

Adeno-associated virus receptor complexes and implications for adeno-associated virus immune neutralization

Frontiers in Microbiology, 2023
Adeno-associated viruses (AAV) are among the foremost vectors for in vivo gene therapy. A number of monoclonal antibodies against several serotypes of AAV have previously been prepared.
Edward E. Large, Michael S. Chapman
doaj   +3 more sources

Adeno-associated virus: from defective virus to effective vector [PDF]

Virology Journal, 2005
The initial discovery of adeno-associated virus (AAV) mixed with adenovirus particles was not a fortuitous one but rather an expression of AAV biology.
Gonçalves Manuel AFV
doaj   +2 more sources

Sclerosing Sialadenitis Is Associated With Salivary Gland Hypofunction and a Unique Gene Expression Profile in Sjögren’s Syndrome

Frontiers in Immunology, 2021
PurposeTo develop a novel method to quantify the amount of fibrosis in the salivary gland and to investigate the relationship between fibrosis and specific symptoms associated with Sjögren’s syndrome (SS) using this method.Materials and MethodsParaffin ...
Hongen Yin, Thomas J. F. Pranzatelli, Benjamin N. French, Nan Zhang, Blake M. Warner, John A. Chiorini, NIDCD/NIDCR Genomics and Computational Biology Core   +6 more
doaj   +1 more source

Advancing Luciferase-Based Antibody Immunoassays to Next-Generation Mix and Read Testing

Biosensors, 2023
Antibody measurements play a central role in the diagnosis of many autoimmune and infectious diseases. One antibody detection technology, Luciferase Immunoprecipitation Systems (LIPS), utilizes genetically encoded recombinant luciferase antigen fusion ...
Peter D. Burbelo, Youngmi Ji, Michael J. Iadarola   +2 more
doaj   +1 more source

Correction of LAMP3-associated salivary gland hypofunction by aquaporin gene therapy

Scientific Reports, 2022
Sjögren’s disease (SjD) is a chronic autoimmune sialadenitis resulting in salivary gland hypofunction with dry mouth symptom. Previous studies showed that lysosome-associated membrane protein 3 (LAMP3) overexpression is involved in the development of ...
Hiroyuki Nakamura, Tsutomu Tanaka, Changyu Zheng, Sandra A. Afione, Blake M. Warner, Masayuki Noguchi, Tatsuya Atsumi, John A. Chiorini   +7 more
doaj   +1 more source

Sarcopenia and coexistent risk factors detected using the ‘Yubi-wakka’ (finger-ring) test in adults aged over 65 years in the public annual health check-up in Tama City, Tokyo: a cross-sectional study

BMJ Open, 2022
Objectives To examine the positive rate of sarcopenia using the ‘Yubi-wakka’ (finger-ring) test and associated risk factors among adults aged 65 years and older.Design Cross-sectional study.Setting We used the Yubi-wakka test, which has been developed ...
Hiroyuki Nakamura, Hitomi Fujii, Eitaro Kodani, Tomohiro Kaneko, Hajime Sasabe, Yutaka Tamura   +5 more
doaj   +1 more source

Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy. [PDF]

, 2014
Hyperammonemia is less severe in arginase 1 deficiency compared with other urea cycle defects. Affected patients manifest hyperargininemia and infrequent episodes of hyperammonemia. Patients typically suffer from neurological impairment with cortical and
Cantero, G, Cantero-Nieto, G, Cederbaum, SD, Chan, E, Hu, C, Lipshutz, GS, Park, H, Tai, DS, Yudkoff, M   +8 more
core   +5 more sources

LAMP3 transfer via extracellular particles induces apoptosis in Sjögren’s disease

Scientific Reports, 2023
Sjögren’s disease (SjD) is an autoimmune disease that affects exocrine tissues and is characterized by increased apoptosis in salivary and lacrimal glands.
Tsutomu Tanaka, Hiroyuki Nakamura, Duy T. Tran, Blake M. Warner, Yan Wang, Tatsuya Atsumi, Masayuki Noguchi, John A. Chiorini   +7 more
doaj   +1 more source

Intravenous immunoglobulin prevents peripheral liver transduction of intrathecally delivered AAV vectors

Molecular Therapy: Methods & Clinical Development, 2022
Gene therapy using neurotropic adeno-associated virus vectors represents an emerging solution for genetic disorders affecting the central nervous system. The first approved central nervous system-targeting adeno-associated virus gene therapy, Zolgensma®,
Makoto Horiuchi, Christian J. Hinderer, Jenny A. Greig, Cecilia Dyer, Elizabeth L. Buza, Peter Bell, Jessica A. Chichester, Peter M. Hayashi, Hanying Yan, Tamara Goode, James M. Wilson   +10 more
doaj   +1 more source