Results 41 to 50 of about 73,712 (118)

Gene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno‐Associated Virus

Advanced Science, 2019
Delivery of genome editing tools to mammalian zygotes has revolutionized animal modeling. However, the mechanical delivery method to introduce genes and proteins to zygotes remains a challenge for some animal species that are important in biomedical ...
Dan Wang, Yuyu Niu, Lingzhi Ren, Yu Kang, Phillip W. L. Tai, Chenyang Si, Craig A. Mendonca, Hong Ma, Guangping Gao, Weizhi Ji   +9 more
doaj   +1 more source

A recombinant avian adeno-associated virus as a vector for infectious bursal disease vaccination.

Revista Científica, 2010
Infectious bursal disease is a worldwide distributed immunosuppressive disease of young chickens that need to be controlled by vaccination; it represents one of the main concerns for the poultry industry.
Francisco Perozo, Pedro Villegas, Carlos Estévez, Ivan Alvarado, Linda Purvis   +4 more
doaj  

Advanced biomanufacturing and evaluation of adeno-associated virus

Journal of Biological Engineering
Recombinant adeno-associated virus (rAAV) has been developed as a safe and effective gene delivery vehicle to treat rare genetic diseases. This study aimed to establish a novel biomanufacturing process to achieve high production and purification of ...
Kai Chen, Seulhee Kim, Siying Yang, Tanvi Varadkar, Zhuoxin Zora Zhou, Jiashuai Zhang, Lufang Zhou, Xiaoguang Margaret Liu   +7 more
doaj   +1 more source

VEGFC/VEGFR3 Signaling‐Dependent Lymphatic Remodeling Modulates Cardiac Response to Pressure Overload

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiac lymphangiogenesis has been proposed as a potential therapeutic target to prevent the development of heart failure. However, the efficiency of systemically delivered VEGFC (vascular endothelial growth factor C) protein in inducing ...
Lina Su, Yuxia Cui, Manyan Wu, Shiran Yu, Chunying Zhang, Ziqi Song, Shuolei Li, Hang Lin, Zheng Lian, Chongyou Lee, Chuanfen Liu, Sufang Li, Junxian Song, Hong Chen   +13 more
doaj   +1 more source

Reduced rAAV interference enhances rcAAV detection sensitivity

Molecular Therapy: Methods & Clinical Development
Replication-competent adeno-associated virus (rcAAV) content is a crucial contaminant in the process of recombinant adeno-associated virus (rAAV) production in gene therapy products, from preclinical to clinical stages.
Ming Yang, Sana Shaheen, Keying Yang, Xuxia Gao, Kaiwen Wu, Xiangying Zhu, Qian Kang, Lu Wang, Farhid Hemmatzadeh, Qingyun Zheng, Chen Ling, Liqing Zhu, Bicui Zhan   +12 more
doaj   +1 more source

Adeno-associated virus-mediated gene therapy for genetic epilepsy: prospects and challenges

中国当代儿科杂志
With the development and launch of anti-seizure medications, some genetic epilepsies have precision treatments; however, many patients remain drug-resistant, which severely affects quality of life and overall health. Advances in gene therapy have changed
SUN Bo, WANG Xiao-Le, PENG Jing
doaj   +1 more source

Metagenomic and transcriptomic investigation of pediatric acute liver failure cases reveals a common pathway predominated by monocytes

mBio
In 2022, a cluster of severe childhood hepatitis was detected primarily in Europe and North America, leading to a global alert by the World Health Organization.
Ruben H. de Kleine, Ellen C. Carbo, Willem S. Lexmond, Xuewei W. Zhou, Alicia de Kroon, Hailiang Mei, Sander T. H. Bontemps, Rick Hennevelt, Lilli Gard, Igor A. Sidorov, Stefan A. Boers, Marius C. van den Heuvel, Emilie P. Buddingh, Aloys C. M. Kroes, Vincent E. de Meijer, Elisabeth H. Schölvinck, Karin J. von Eije, Simon P. Jochems, Jutte J. C. de Vries   +18 more
doaj   +1 more source

Adeno-associated virus-mediated neuroglobin overexpression ameliorates the N-methyl-N-nitrosourea-induced retinal impairments: a novel therapeutic strategy against photoreceptor degeneration

Therapeutics and Clinical Risk Management, 2017
Ye Tao,1,* Zhen Yang,2,* Wei Fang,2 Zhao Ma,3 Yi Fei Huang,1 Zhengwei Li4 1Department of Ophthalmology, Key Lab of Ophthalmology and Visual Science, Chinese PLA General Hospital, Beijing, 2Department of Neurosurgery, Institute for Functional Brain ...
Tao Y, Yang Z, Fang W, Ma Z, Huang YF, Li Z   +5 more
doaj  

Adeno-Associated Virus Gene Therapy: Is There a Risk of Insertional Mutagenesis? [PDF]

Toxicol Pathol
Batty P.
europepmc   +1 more source

Distinct YY dinucleotide periodicity in adeno-associated virus DNA. [PDF]

Mol Ther
Baumgartl C, Becker J, Naber L, Xu M, Gerstmann E, Gonzalez-Calero JG, Suppacher J, Heß S, Bubeck F, Grimm D.   +9 more
europepmc   +1 more source