Results 21 to 30 of about 214,719 (303)

Herpes simplex virus co-infection facilitates rolling circle replication of the adeno-associated virus genome. [PDF]

, 2021
Adeno-associated virus (AAV) genome replication only occurs in the presence of a co-infecting helper virus such as adenovirus type 5 (AdV5) or herpes simplex virus type 1 (HSV-1).
Anouk Lkharrazi, Cornel Fraefel, Ros, Carlos, Fraefel, Cornel, Remo Leisi, Anita Felicitas Meier, Carlos Ros, Lkharrazi, Anouk, Tobler, Kurt, Leisi, Remo, Kurt Tobler, Meier, Anita Felicitas   +11 more
core   +1 more source

Progress in the use of adeno-associated viral vectors for gene therapy [PDF]

, 2004
The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Markus Braun-Falco, Hallek, M., Michael Hallek, Buning, H., Braun-Falco, M., Hildegard Büning   +5 more
core   +1 more source

Adeno-associated Virus DNA Replication [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 1979
ABSTRACT. A model for the replication of adeno-associated virus (AAV) DNA is presented. The AAV genome is a linear single-stranded DNA molecule which contains a 145 nucleotide inverted terminal repetition of which the first 125 nucleotides form a palindromic sequence.
K I, Berns, W W, Hauswirth, K H, Fife, E, Lusby   +3 more
openaire   +2 more sources

Muscle regeneration affects Adeno Associated Virus 1 mediated transgene transcription

Scientific Reports, 2022
Duchenne muscular dystrophy is a severe neuromuscular disease causing a progressive muscle wasting due to mutations in the DMD gene that lead to the absence of dystrophin protein.
Amédée Mollard, Cécile Peccate, Anne Forand, Julie Chassagne, Laura Julien, Pierre Meunier, Zoheir Guesmia, Thibaut Marais, Marc Bitoun, France Piétri-Rouxel, Sofia Benkhelifa-Ziyyat, Stéphanie Lorain   +11 more
doaj   +1 more source

Process Improvement of Adeno-Associated Virus Production

Frontiers in Chemical Engineering, 2022
Adeno-associated viruses (AAVs) have been well characterized and used to deliver therapeutic genes for diseases treatment in clinics and basic research. This study used the triple transient transfection of AAV-DJ/8 as a model expression system to develop
Jia-Shiung Guan, Kai Chen, Yingnan Si, Taehyun Kim, Zhuoxin Zhou, Seulhee Kim, Lufang Zhou, Xiaoguang Liu   +7 more
doaj   +1 more source

Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors [PDF]

, 2004
BACKGROUND: Inactivating genes in vivo is an important technique for establishing their function in the adult nervous system. Unfortunately, conventional knockout mice may suffer from several limitations including embryonic or perinatal lethality and the
Hermens, Wim T J M C, Lieberman, A., Eggers, R., Verhaagen, J., Sablitzky, Fred, Chakravarthy, Sridhara, Zhang, Jing Ying, Zhang, J.Y., Hermens, Wim TJMC, Zhang, Jing, Verhaagen, J, Ahmed, Bushra, Anderson, P.N., Eggers, R, Eggers, Ruben, Levelt, Christiaan, Chakravarthy, S, Levelt, C., Ahmed, BY, Verhaagen, Joost, Lieberman, A.R., Hermens, WTJMC, Lieberman, AR, Niclou, Simone P, Anderson, Patrick N., Ahmed, Bushra Y, Hermens, W.T., Niclou, SP, Anderson, PN, NICLOU, Simone P., Lieberman, A R, Zhang, JY, Anderson, Patrick N, Sablitzky, F., Levelt, C, Sablitzky, F, Niclou, S.P., Lieberman, A Robert, Chakravarthy, S., Ahmed, B.Y.   +39 more
core   +1 more source

Adeno-Associated Virus Vectors and Hematology [PDF]

Blood, 1999
Gene therapists have a special fondness for hematology. Initially, this was due to the many inherited diseases that could potentially be cured by ex vivo genetic modification of hematopoietic stem cells. Once the early murine leukemia virus (MLV) vectors were found to transduce only a small percentage of primate stem cells, the search began for other ...
D W, Russell, M A, Kay
openaire   +2 more sources

Expression Profiles of Bovine Adeno-Associated Virus and Avian Adeno-Associated Virus Display Significant Similarity to That of Adeno-Associated Virus Type 5 [PDF]

Journal of Virology, 2006
ABSTRACT We present the first detailed expression profiles of nonprimate-derived adeno-associated viruses, namely, bovine adeno-associated virus (B-AAV) and avian adeno-associated virus (A-AAV), which were obtained after the infection of cell lines derived from their natural hosts.
Jianming, Qiu, Fang, Cheng, David J, Pintel   +2 more
openaire   +2 more sources

Gene-edited pseudogene resurrection corrects p47phox-deficient chronic granulomatous disease

Blood Advances, 2017
: Pseudogenes are duplicated genes with mutations rendering them nonfunctional. For single-gene disorders with homologous pseudogenes, the pseudogene might be a target for genetic correction.
Randall K. Merling, Douglas B. Kuhns, Colin L. Sweeney, Xiaolin Wu, Sandra Burkett, Jessica Chu, Janet Lee, Sherry Koontz, Giovanni Di Pasquale, Sandra A. Afione, John A. Chiorini, Elizabeth M. Kang, Uimook Choi, Suk See De Ravin, Harry L. Malech   +14 more
doaj   +1 more source

Adeno-associated virus: fit to serve [PDF]

Current Opinion in Virology, 2014
Adeno-associated virus (AAV) is a helper-dependent parvovirus which has not been linked with human disease. This aspect, in combination with its broad cell and tissue tropism, and limited viral host response has made it an attractive vector system for gene therapy.
Eric Zinn, Luk H Vandenberghe
openaire   +2 more sources