Results 11 to 20 of about 8,933,423 (298)
LAMP3 transfer via extracellular particles induces apoptosis in Sjögren’s disease
Scientific Reports, 2023 Sjögren’s disease (SjD) is an autoimmune disease that affects exocrine tissues and is characterized by increased apoptosis in salivary and lacrimal glands.
Tsutomu Tanaka +7 more
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Therapeutics and Clinical Risk Management, 2017 Ye Tao,1,* Zhen Yang,2,* Wei Fang,2 Zhao Ma,3 Yi Fei Huang,1 Zhengwei Li4 1Department of Ophthalmology, Key Lab of Ophthalmology and Visual Science, Chinese PLA General Hospital, Beijing, 2Department of Neurosurgery, Institute for Functional Brain ...
Tao Y +5 more
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Molecular Therapy: Methods & Clinical Development, 2022 Gene therapy using neurotropic adeno-associated virus vectors represents an emerging solution for genetic disorders affecting the central nervous system. The first approved central nervous system-targeting adeno-associated virus gene therapy, Zolgensma®,
Makoto Horiuchi +10 more
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Adeno‐associated virus (AAV)-based gene therapy for glioblastoma
Cancer Cell International, 2021 Glioblastoma (GBM) is the most common and malignant Grade IV primary craniocerebral tumor caused by glial cell carcinogenesis with an extremely poor median survival of 12–18 months.
Xin Xu +9 more
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Infectious Entry Pathway of Adeno-Associated Virus and Adeno-Associated Virus Vectors [PDF]
Journal of Virology, 2000 ABSTRACT We have investigated the infectious entry pathway of adeno-associated virus (AAV) and recombinant AAV vectors by assessing AAV-mediated gene transfer and by covalently conjugating fluorophores to AAV and monitoring entry by fluorescence microscopy.
J S, Bartlett, R, Wilcher, R J, Samulski
openaire +2 more sources
Transduction of Salivary Gland Acinar Cells with a Novel AAV Vector 44.9
Molecular Therapy: Methods & Clinical Development, 2020 The loss of salivary gland function caused by radiation therapy of the head and neck or autoimmune disease such as Sjögren’s syndrome is a serious condition that affects a patient’s quality of life. Due to the combined exocrine and endocrine functions of
Giovanni Di Pasquale +14 more
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Advances in Rheumatology, 2022 Background Sjögren Syndrome (SS) is a systemic autoimmune disease with a wide spectrum of manifestations that can lead to misdiagnosis. This study describes and compares demographic, clinical, serological, and histopathological data from subjects with SS
Fabíola Reis de Oliveira +6 more
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Development of a self-silencing adenovirus for the efficient manufacture of adeno-associated virus vectors [PDF]
, 2021 Adeno-associated virus (AAV) shows great promise for gene therapy, however scalability, yield and quality remain significant issues. The most common ‘helper-free’ method used to produce recombinant AAV (rAAV) for pre-clinical/clinical application is ...
Su, Weiheng
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Progress in the use of adeno-associated viral vectors for gene therapy [PDF]
, 2004 The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Markus Braun-Falco +7 more
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Muscle regeneration affects Adeno Associated Virus 1 mediated transgene transcription
Scientific Reports, 2022 Duchenne muscular dystrophy is a severe neuromuscular disease causing a progressive muscle wasting due to mutations in the DMD gene that lead to the absence of dystrophin protein.
Amédée Mollard +11 more
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