Results 221 to 230 of about 110,488 (256)

Role of the UHRF1–KLHL6–CORO2B axis in obesity‐related insulin resistance

Journal of Diabetes Investigation, EarlyView.
In high‐fat diet (HFD)‐induced obese mice with insulin resistance, overexpression of UHRF1 may recruit DNMT1 to promote DNA methylation of KLHL6, leading to its downregulation. Subsequently, suppression of KLHL6 may decrease the ubiquitination of CORO2B, resulting in elevated CORO2B protein levels.
Xu Deng, Xiaoping Li, Jialuo Cai, Xinyu Chen, Zelin Xu, Yuntao Luo   +5 more
wiley   +1 more source

Functional orthogonality of parvoviral phospholipase A₂ domains in adeno-associated virus transduction. [PDF]

J Virol
Hull JA, Fusco RM, Tan J, Ochoa MA, Hall A, Wan X, Loeb E, Asokan A.   +7 more
europepmc   +1 more source

Automated real-time collection of pathogen-specific diagnostic data: Syndromic infectious disease epidemiology [PDF]

, 2018
et al,, Storch, Gregory A
core   +1 more source

Techniques for subretinal injections in animals

Veterinary Ophthalmology, Volume 28, Issue 2, Page 506-518, March 2025.
Abstract Subretinal injections are not commonly performed during clinical treatment of animals but are frequently used in laboratory animal models to assess therapeutic efficacy and safety of gene and cell therapy products. Veterinary ophthalmologists are often employed to perform the injections in the laboratory animal setting, due to knowledge of ...
Ryan F. Boyd, Simon M. Petersen‐Jones
wiley   +1 more source

Adeno-associated virus-miR-128-3p sponge regulates breast muscle growth and intramuscular fat content in chickens. [PDF]

Food Chem (Oxf)
Zhu T, Deng L, He Y, Liang W, Liu P, Liu S, Guo H, Li D, Yan F, Tian Y, Jiang R, Kang X, Jin W, Li Z, Li W, Sun G.   +15 more
europepmc   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source

Adeno-associated virus serotype 9 structural heterogeneity and stability characterized by charge detection mass spectrometry. [PDF]

Mol Ther Methods Clin Dev
Miller ZM, Lin LF, Schaffer DV, Williams ER.   +3 more
europepmc   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Impact of multiplicity of infection and baculovirus co-infection ratio on recombinant adeno-associated virus vector production in insect cells. [PDF]

Front Bioeng Biotechnol
Schrama M, de Jong LA, Kint S, Puri P, Hoeksema F, Pijlman GP, van Oers MM, Wijffels RH, Martens DE.   +8 more
europepmc   +1 more source

Development and implementation of an LC-MS-based multi-attribute method for adeno-associated virus. [PDF]

Mol Ther Methods Clin Dev
Powers TW, Mariani S, Narepekha H, Ryan D, Sankar S, Lerch TF.   +5 more
europepmc   +1 more source