Results 1 to 10 of about 2,159 (69)

Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry

Viruses, 2021
Human gene therapy has advanced from twentieth-century conception to twenty-first-century reality. The recombinant Adeno-Associated Virus (rAAV) is a major gene therapy vector. Research continues to improve rAAV safety and efficacy using a variety of AAV
Edward E. Large, Mark A. Silveria, Grant M. Zane, Onellah Weerakoon, Michael S. Chapman   +4 more
doaj   +3 more sources

Activin A improves the outcomes of neurological function in mice with ischemic stroke through ACVR1C of oligodendrocytes [PDF]

Jichu yixue yu linchuang, 2023
Objective The role of activin A receptor type 1C(ACVR1C) in white matter remyelination and neurological outcome of mice with ischemic stroke were investigated.
LI Yudie, WANG Hongyu, HAN Song, LI Junfa
doaj   +1 more source

Sclerosing Sialadenitis Is Associated With Salivary Gland Hypofunction and a Unique Gene Expression Profile in Sjögren’s Syndrome

Frontiers in Immunology, 2021
PurposeTo develop a novel method to quantify the amount of fibrosis in the salivary gland and to investigate the relationship between fibrosis and specific symptoms associated with Sjögren’s syndrome (SS) using this method.Materials and MethodsParaffin ...
Hongen Yin, Thomas J. F. Pranzatelli, Benjamin N. French, Nan Zhang, Blake M. Warner, John A. Chiorini, NIDCD/NIDCR Genomics and Computational Biology Core   +6 more
doaj   +1 more source

Long-Term Liver Expression of an Apolipoprotein A-I Mimetic Peptide Attenuates Interferon-Alpha-Induced Inflammation and Promotes Antiviral Activity

Frontiers in Immunology, 2021
Apolipoprotein A-I mimetic peptides are amphipathic alpha-helix peptides that display similar functions to apolipoprotein A-I. Preclinical and clinical studies have demonstrated the safety and efficacy of apolipoprotein A-I mimetic peptides in multiple ...
Myriam Fernandez-Sendin, Myriam Fernandez-Sendin, Claudia Augusta Di Trani, Claudia Augusta Di Trani, Angela Bella, Angela Bella, Marcos Vasquez, Marcos Vasquez, Nuria Ardaiz, Nuria Ardaiz, Celia Gomar, Celia Gomar, Leire Arrizabalaga, Leire Arrizabalaga, Sergio Ciordia, Sergio Ciordia, Fernando J. Corrales, Fernando J. Corrales, Fernando Aranda, Fernando Aranda, Pedro Berraondo, Pedro Berraondo, Pedro Berraondo   +22 more
doaj   +1 more source

Fluorescence Microscopy in Adeno-Associated Virus Research

Viruses, 2023
Research on adeno-associated virus (AAV) and its recombinant vectors as well as on fluorescence microscopy imaging is rapidly progressing driven by clinical applications and new technologies, respectively.
Susanne K. Golm, Wolfgang Hübner, Kristian M. Müller   +2 more
doaj   +1 more source

In vivo generation of collagen specific Tregs with AAV8 suppresses autoimmune responses and arthritis in DBA1 mice through IL10 production

Scientific Reports, 2021
Available therapeutics for autoimmune disorders focused on mitigating symptoms, rather than treating the cause of the disorder. A novel approach using adeno-associated virus (AAV) could restore tolerance to the autoimmune targets and provide a permanent ...
Matthew Wade, Hugues Fausther-Bovendo, Marc-Antoine De La Vega, Gary Kobinger   +3 more
doaj   +1 more source

A dual role for adeno-associated virus in human health

Virology Journal, 2023
Adeno-associated virus (AAV) differs from most other viruses, as it requires the simultaneous presence of a helper virus for an active infection. Up to 80% of the human population is seropositive for AAV antibodies.
Natalia M Araujo
doaj   +1 more source

Successful Transduction with AAV Vectors after Selective Depletion of Anti-AAV Antibodies by Immunoadsorption

Molecular Therapy: Methods & Clinical Development, 2020
Gene therapy with adeno-associated virus (AAV)-based vectors shows great promise for the gene therapeutic treatment of a broad array of diseases. In fact, the treatment of genetic diseases with AAV vectors is currently the only in vivo gene therapy ...
Alejandro Orlowski, Michael G. Katz, Sarah M. Gubara, Anthony S. Fargnoli, Kenneth M. Fish, Thomas Weber   +5 more
doaj   +1 more source

Construction and expression verification of mouse spermatogenic cell-specific expression vector AAV-Dazl-RFP-Flag [PDF]

Jichu yixue yu linchuang, 2020
Objective To study the effect of spermatogenic cell-specific promoter Dazl in Spermatogenic cells. Constructing the eukaryotic reporter gene expression vector AAV-Dazl-RFP-Flag containing spermatogenic cell-specific promoter Dazl.
LI Ya-hui, LI Kai, LUO Yan-yun, LI Meng-zhen, MANG Xin-yu, SONG Wei, YANG Tao
doaj  

Analysis of Replicative Intermediates of Adeno-associated Virus through Hirt Extraction and Southern Blotting

Bio-Protocol, 2017
Adeno-associated virus (AAV) is a small single-stranded DNA virus that requires the presence of a helper virus, such as adenovirus or herpes virus, to efficiently replicate its genome.
Martino Bardelli, Francisco Zarate-Perez, Leticia Agundez, Nelly Jolinon, R. Linden, Carlos Escalante, Els Henckaerts   +6 more
doaj   +1 more source