Results 161 to 170 of about 9,649,206 (293)

New strategies for the application of Adeno-Associated Virus type 2 targeting vectors [PDF]

, 2006
Goldnau, Daniela
core   +1 more source

Aquaporin-1 gene therapy as a novel method to treat radiation-induced salivary gland damage: The case for adeno-associated virus vectors. [PDF]

Oral Oncol
Atyeo N, Warner B, Chiorini JA.
europepmc   +1 more source

Only a small fraction of cells produce assembled capsids during transfection-based manufacturing of adeno-associated virus vectors. [PDF]

Biotechnol Bioeng, 2022
Dash S, Sharon DM, Mullick A, Kamen AA.
europepmc   +1 more source

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

Distinguishing Pseudotransduction and True Transduction Enables Characterization and Bioengineering of Extracellular Vesicle-Adeno-Associated Virus Vectors. [PDF]

J Extracell Vesicles
Boucher JD, Stranford DM, Edelstein HI, Tullman-Ercek D, Kamat NP, Leonard JN.   +5 more
europepmc   +1 more source

Chemical Modifications of the Capsid for Redirecting and Improving the Efficacy of Adeno-Associated Virus Vectors. [PDF]

Hum Gene Ther, 2021
Lam AK, Frabutt D, Li L, Xiao W.
europepmc   +1 more source

RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses

Advanced Science, EarlyView.
Postoperative arteriovenous fistulas exhibit increased RBMS1 in vascular smooth muscle cells (VSMCs). In experimental AVFs, RBMS1 overexpression aggravates, whereas deletion attenuates, neointimal hyperplasia. RBMS1 binds MPZL1 mRNA and promotes exon 5 skipping to generate MPZL1‐Δ5, which interacts with G3BP1 to activate AKT, driving VSMC proliferation,
Zongda Li, Chengwei Zhang, Xinying Yu, Shuang Yao, Yiting Lai, Xiaozhu Sun, Yao Zhao, Xiaoyu Lan, Tingting Hu, Wenjin Li, Zhenzhen Ma, Huimin Ma, Zihan Wang, Haihai Liang, Jundong Jiao   +14 more
wiley   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Manufacture of adeno-associated virus vectors by a novel human-derived cell line HAT and comprehensive evaluation of the vectors. [PDF]

Mol Ther Adv
Tsunaka Y, Fukuhara M, Shimojo S, Matsushita A, Maruno T, Soth S, Nishiumi H, Vergara Rocafort MA, Kuwahara T, Matsumoto K, Shibata K, Nakatsuka R, Asahina R, Mizukado S, Fukai Y, Togashi T, Baatartsogt N, Takeda K, Kuno A, Kashiwakura Y, Yamaguchi Y, Nakamura K, Hirai Y, Hirai H, Ohmori T, Omasa T, Uchiyama S.   +26 more
europepmc   +1 more source

Neutralizing Antibody Evasion and Transduction with Purified Extracellular Vesicle-Enveloped Adeno-Associated Virus Vectors. [PDF]

Hum Gene Ther, 2021
Cheng M, Dietz L, Gong Y, Eichler F, Nammour J, Ng C, Grimm D, Maguire CA.   +7 more
europepmc   +1 more source