Results 201 to 210 of about 36,553 (255)
Phytotherapy Research, EarlyView.COR stabilizes GCH1 and inhibits ferroptosis. ABSTRACT To investigate the effects and targets of cordycepin (COR) in alleviating non‐alcoholic fatty liver disease (NAFLD). High‐fat diet was used to induce NAFLD in mice, and after COR gavage administration, changes in liver function, glucose and lipid metabolism, and ferroptosis‐related signaling were ...
Chenyang Han +7 more
wiley +1 more source
Sensory Neuroscience, EarlyView.Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa +5 more
wiley +1 more source
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Adeno-associated virus vectors
Current Opinion in Biotechnology, 1992Adeno-associated virus is a human parvovirus that integrates its DNA genome into host cell chromosomes with very high efficiency. This suggests that adeno-associated virus may be a useful vector for human gene therapy. Interest in adeno-associated virus vectors increased greatly in the last year following reports that adeno-associated virus genome ...
Barrie J Carter, B J Carter
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Adenovirus and Adeno-Associated Virus Vectors
DNA and Cell Biology, 2002Recombinant adenovirus (rAd) and recombinant adeno-associated virus (rAAV) are among the most extensively used vectors in gene therapy studies to date. These two vectors share some similar features such as a broad host range and ability to infect both proliferating and quiescent cells.
Chooi May, Lai +2 more
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Hematology/Oncology Clinics of North America, 2022
Although the number of market-approved gene therapies is still low, this new class of therapeutics has become an integral part of modern medicine. The success and safety of gene therapy depend on the vectors used to deliver the therapeutic material. Adeno-associated virus (AAV) vectors have emerged as the most frequently used delivery system for in ...
Nico, Jäschke, Hildegard, Büning
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Although the number of market-approved gene therapies is still low, this new class of therapeutics has become an integral part of modern medicine. The success and safety of gene therapy depend on the vectors used to deliver the therapeutic material. Adeno-associated virus (AAV) vectors have emerged as the most frequently used delivery system for in ...
Nico, Jäschke, Hildegard, Büning
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Immune Responses to Adeno-Associated Virus Vectors
Current Gene Therapy, 2005One of the biggest challenges in optimizing viral vectors for gene therapy relates to the immune response of the host. Adeno-associated virus (AAV) vectors are associated with low immunogenicity and toxicity, resulting in vector persistence and long-term transgene expression.
Anne K, Zaiss, Daniel A, Muruve
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Adeno-Associated Virus (AAV) Vectors in the CNS
Current Gene Therapy, 2005Adeno-associated virus (AAV) vectors exhibit a number of properties that have made this vector system an excellent choice for both CNS gene therapy and basic neurobiological investigations. In vivo, the preponderance of AAV vector transduction occurs in neurons where it is possible to obtain long-term, stable gene expression with very little ...
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Production of Recombinant Adeno-Associated Virus Vectors
Human Gene Therapy, 2005Recombinant adeno-associated virus (rAAV) is a prototypical gene therapy vector characterized by excellent safety profiles, wide host range, and the ability to transduce differentiated cells. Numerous rAAV-based vectors providing efficient and sustained expression of transgenes in target tissues have been developed for preclinical studies.
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Adeno-Associated Virus Vector Delivery to the Heart
2011Cardiac gene transfer may serve as a novel therapeutic approach in the treatment of heart disease. For it to reach its full potential, methods for highly efficient cardiac gene transfer must be available to investigators so that informative preclinical data can be collected and evaluated.
Lawrence T, Bish +3 more
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Adeno-associated Virus Based Vectors As Antivirals
1996Although great strides have been made in the treatment and prevention of human viral infections, antiviral drug therapy still remains problematic when compared to treatment of bacterial infections. The therapeutic toxicity/efficacy ratio of many antivirals is low, resulting in potential risks of regimen related toxicity.
K K, Wong, S, Chatterjee
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