Results 241 to 250 of about 9,649,206 (293)

Adeno-Associated Virus Vector Design–Moving the Adeno-Associated Virus to a Bioengineered Therapeutic Nanoparticle

Hematology/Oncology Clinics of North America, 2022
Although the number of market-approved gene therapies is still low, this new class of therapeutics has become an integral part of modern medicine. The success and safety of gene therapy depend on the vectors used to deliver the therapeutic material. Adeno-associated virus (AAV) vectors have emerged as the most frequently used delivery system for in ...
Nico, Jäschke, Hildegard, Büning
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Adeno-Associated Virus (AAV) Vectors in the CNS

Current Gene Therapy, 2005
Adeno-associated virus (AAV) vectors exhibit a number of properties that have made this vector system an excellent choice for both CNS gene therapy and basic neurobiological investigations. In vivo, the preponderance of AAV vector transduction occurs in neurons where it is possible to obtain long-term, stable gene expression with very little ...
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Production of Recombinant Adeno-Associated Virus Vectors

Human Gene Therapy, 2005
Recombinant adeno-associated virus (rAAV) is a prototypical gene therapy vector characterized by excellent safety profiles, wide host range, and the ability to transduce differentiated cells. Numerous rAAV-based vectors providing efficient and sustained expression of transgenes in target tissues have been developed for preclinical studies.
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Adeno-Associated Virus Vector Delivery to the Heart

2011
Cardiac gene transfer may serve as a novel therapeutic approach in the treatment of heart disease. For it to reach its full potential, methods for highly efficient cardiac gene transfer must be available to investigators so that informative preclinical data can be collected and evaluated.
Lawrence T, Bish, H Lee, Sweeney, Oliver J, Müller, Raffi, Bekeredjian   +3 more
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Adeno-associated Virus Based Vectors As Antivirals

1996
Although great strides have been made in the treatment and prevention of human viral infections, antiviral drug therapy still remains problematic when compared to treatment of bacterial infections. The therapeutic toxicity/efficacy ratio of many antivirals is low, resulting in potential risks of regimen related toxicity.
K K, Wong, S, Chatterjee
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Packaging Systems for Adeno-associated Virus Vectors

1996
The promise and hopes that gene therapy vectors derived from adeno-associated virus (AAV) will make the leap from the laboratory bench to the clinic bedside are thoroughly described in this volume of Current Topics of Microbiology and Immunology. As more investigators enter this rapidly growing field, AAV’s ability to deliver genes of therapeutic ...
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Quality Control Testing, Characterization and Critical Quality Attributes of Adeno-Associated Virus Vectors Used for Human Gene Therapy

Biotechnology Journal, 2021
John Fraser Wright
exaly  

Adeno-Associated Virus Genome Interactions Important for Vector Production and Transduction

Human Gene Therapy, 2020
Matthew D Weitzman
exaly  

Adeno-Associated Virus and Vector

2016
Chen Ling, Daniel Zhang
openaire   +1 more source

Engineering Adeno-Associated Virus Vectors for Gene Therapy

Nature Reviews Genetics, 2020
Chengwen Li, R Jude Samulski
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